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J Child Neurol ; 31(2): 184-9, 2016 Feb.
Article in English | MEDLINE | ID: mdl-25999301

ABSTRACT

This retrospective study aimed to compare the therapeutic response, including side effects, for oral baclofen versus oral tizanidine therapy with adjuvant botulinum toxin type A in a group of 64 pediatric patients diagnosed with static encephalopathy and spastic equinus foot deformity. Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose. Gross Motor Functional Measure and Caregiver Health Questionnaire scores were markedly elevated post-botulinum toxin A treatment, with scores for the tizanidine (Gross Motor Functional Measure: 74.45 ± 3.72; Caregiver Health Questionnaire: 72.43 ± 4.29) group significantly higher than for the baclofen group (Gross Motor Functional Measure: 68.23 ± 2.66; Caregiver Health Questionnaire: 67.53 ± 2.67, P < .001). These findings suggest that the combined use of botulinum toxin A and a low dose of tizanidine in treating children with cerebral palsy appears to be more effective and has fewer side effects versus baclofen with adjuvant botulinum toxin A.


Subject(s)
Baclofen/administration & dosage , Botulinum Toxins, Type A/administration & dosage , Cerebral Palsy/drug therapy , Clonidine/analogs & derivatives , Equinus Deformity/drug therapy , Neuromuscular Agents/administration & dosage , Administration, Oral , Adolescent , Baclofen/adverse effects , Botulinum Toxins, Type A/adverse effects , Cerebral Palsy/complications , Child , Child, Preschool , Clonidine/administration & dosage , Clonidine/adverse effects , Drug Therapy, Combination/adverse effects , Equinus Deformity/complications , Female , Follow-Up Studies , Humans , Male , Muscle Spasticity/complications , Muscle Spasticity/drug therapy , Neuromuscular Agents/adverse effects , Retrospective Studies , Severity of Illness Index , Treatment Outcome
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