[Immunity and resistance in experimental tuberculosis in mice exposed to various environmental factors]. / Immunitet i rezistentnost pri éksperimentalnom tuberkulëze u myshei, nakhodiashchikhsia v raznykh usloviiakh soderzhaniia.

CBA mice maintained on the chow and water with either normal or deficient in particular trace elements were infected with M. tuberculosis H37Rv. Mice with deficiency of silicon showed a tendency for decreased survival, had less active DTH response to tuberculin and proliferation in vitro upon stimulation by mycobacterial antigens and nonspecific mytogens than mice on balanced diet, higher levels of specific IgG. Addition of silicon to the diet of silicon-deficient mice corrected antituberculosis immunity.

[Development of protective antituberculosis immunity after BCG vaccination in mice with silicon deficiency in water and feed]. / Formirovanie protektivnogo protivotuberkuleznogo immuniteta posle vaktsinatsii BTsZh u myshei pri nedostatke kremniia v vode i kormakh.

An experimental mouse model of normal and deficient content of silicon in the diet in CBA strain has been developed. It is shown that after BCG vaccination silicon deficiency brought about a dramatic decrease of in vitro proliferation of splenic lymphocytes in the presence of mycobacterial antigens, ConA or in the absence of the stimuli. DTH response to tuberculin in silicon deficient mice was also reduced. The level of specific serum IgG did not depend upon silicon content in the diet. The addition of silicon into the diet of silicon-deficient mice beginning from BCG vaccination restored the level of immune reactions.