ABSTRACT
Behcet's disease is a chronic multisystemic disease of unknown pathogenesis characterized by four major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. The disease is spread throughout the world, but it is most frequent in Turkey, Japan, Korea and China. Although HLA-Bw51 has been found to predominate in Behcet's cases, the genetic etiology has not yet been clarified. In this study, we investigated the chromosomal abnormalities and sister chromatid exchange rates in patients with Behcet's diseases. Thirty-eight patients with Behcet's disease (diagnosed for the first time) and 30 healthy subjects (as controls) were included in this study. Although numerical and structural chromosomal abnormalities were not detected in our patients, we found an increased rate of sister chromatid exchange in patients over the control groups (P < 0.01). On the basis of these results, we discuss the genetic etiology of Behcet's disease.
Subject(s)
Behcet Syndrome/genetics , Chromosome Aberrations , Sister Chromatid Exchange/genetics , Adolescent , Adult , Case-Control Studies , Female , Humans , Male , Middle AgedABSTRACT
PURPOSE: A case of bilateral arcus-like corneal degeneration in the medial limbal regions following bilateral bicanalicular silicone intubation is reported. METHODS: Case report. RESULTS: Bilateral arcus-like corneal opacifications were observed in the medial limbal regions of a 33-year-old woman 3 months after the bilateral silicone intubation with dacryocystorhinostomy. No clinical signs of infection and direct contact of the silicone tubes with those regions of the corneas were observed. Routine laboratory tests revealed no abnormalities, and serum lipoprotein composition was normal. CONCLUSIONS: Silicone tubing appeared to be the precipitating factor of the corneal opacifications that occurred in this patient.
