1.
Bioorg Khim
; 33(5): 538-43, 2007.
Article
in Russian
| MEDLINE
| ID: mdl-18050659
ABSTRACT
A convenient approach to the synthesis of mono- and polycationic glycolipid amphiphiles is suggested. The compounds obtained can be used for study of the structure-activity relationship and determination of the effect of hydrophobic and cationic domains on transfection efficiency.
Subject(s)
Glycolipids/chemistry , Polyamines/chemistry , Transfection , Acylation , Animals , Carbohydrates/chemical synthesis , Carbohydrates/chemistry , Glycolipids/chemical synthesis , Liposomes/chemistry , Polyamines/chemical synthesis , Polyelectrolytes
2.
Bioorg Khim
; 29(3): 323-5, 2003.
Article
in Russian
| MEDLINE
| ID: mdl-12845809
ABSTRACT
A glucosyldiglyceride containing residues of 11-aminoundecanoic acid was synthesized for constructing pH-sensitive liposomes.
Subject(s)
Biochemistry/methods , Glycolipids/chemical synthesis , Liposomes , Glucose/chemistry , Glycerides/chemistry , Glycolipids/chemistry , Hydrogen-Ion Concentration , Liposomes/chemical synthesis , Liposomes/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure
3.
Bioorg Khim
; 26(9): 703-6, 2000 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-11036530
ABSTRACT
A series of glucosyl dialkylglycerols with the pyridinium, N-morpholinium, and N-methylimidazolium polar heads were synthesized by quaternization of the corresponding bases with the acetylated glucosyl diglyceride 6-O-methane- and 6-O-toluenesulfonates. The resulting compounds were designed for the use in gene delivery systems.
