ABSTRACT
The levels of neurospecific peptides in the systemic circulation and the rate of biological aging of veterans of war in Afghanistan were studied. A significant increase in the level of matrix metalloproteinase-9 reflecting the increased permeability of the blood-brain barrier in the initial manifestations of insufficient blood supply to the brain was found. After a course of general aerocryotherapy the optimization of biological and cardiopulmonary age were marked, which indicates a slowing of the biological aging.
Subject(s)
Aging, Premature/therapy , Blood-Brain Barrier , Brain Ischemia , Capillary Permeability , Cryotherapy/methods , Nerve Tissue Proteins/metabolism , Adult , Afghan Campaign 2001- , Blood-Brain Barrier/metabolism , Blood-Brain Barrier/physiopathology , Brain Ischemia/diagnosis , Brain Ischemia/metabolism , Brain Ischemia/physiopathology , Humans , Male , Matrix Metalloproteinase 9/metabolism , Treatment Outcome , Veterans , Veterans HealthABSTRACT
Using the Bioage and Snake software the immune and cardiovascular system aging rate was diagnosed in patients having early forms of chronic cerebrovascular diseases (CCVD). The indicators of biological, cardiopulmonary and immunological age were studied in patients showing early symptoms of cerebrovascular insufficiency and dyscirculatory encephalopathy of the 1st stage. The rate of age-dependent physiological changes was diagnosed compared to general body aging rate. Some specific patterns of immune system aging were found in patients with early forms of CCVDs, the cardinal aging symptoms (heterotropia, heterochronia) were verified.
