Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 18 de 18
Filter
1.
BMC Med Inform Decis Mak ; 22(1): 66, 2022 03 15.
Article in English | MEDLINE | ID: mdl-35292008

ABSTRACT

BACKGROUND: Information on the use of change management models to guide electronic medical records (EMR) implementation is limited. This case study describes the leadership aspects of a large-scale EMR implementation using Kotter's change management model. METHODS: This case study presents the experience in implementing a new EMR system from the leadership perspective at King Abdulaziz Medical City, a large tertiary care hospital in Riyadh, Kingdom of Saudi Arabia. We described the process of implementation and outlined the challenges and opportunities, throughout the journey from the pre-implementation to the post-implementation phases. RESULTS: We described the corresponding actions to the eight domains of Kotter's change management model: creating a sense of urgency, building the guiding team, developing a change vision and strategy, understanding and buy-in, removing obstacles, creating short-term wins, building on the change and anchoring the changes in corporate culture. CONCLUSIONS: The case study highlights that EMR implementation is not a pure information technology project but rather is a technical-based complex social adaptive project that requires a specific set of leadership competencies that are central to its success. It demonstrates that change management models might be useful for large-scale EMR implementation.


Subject(s)
Electronic Health Records , Leadership , Delivery of Health Care , Humans , Saudi Arabia
2.
JAMA Netw Open ; 5(2): e220214, 2022 02 01.
Article in English | MEDLINE | ID: mdl-35195701

ABSTRACT

Importance: COVID-19 has highlighted widespread chronic underinvestment in digital health that hampered public health responses to the pandemic. Recognizing this, the Riyadh Declaration on Digital Health, formulated by an international interdisciplinary team of medical, academic, and industry experts at the Riyadh Global Digital Health Summit in August 2020, provided a set of digital health recommendations for the global health community to address the challenges of current and future pandemics. However, guidance is needed on how to implement these recommendations in practice. Objective: To develop guidance for stakeholders on how best to deploy digital health and data and support public health in an integrated manner to overcome the COVID-19 pandemic and future pandemics. Evidence Review: Themes were determined by first reviewing the literature and Riyadh Global Digital Health Summit conference proceedings, with experts independently contributing ideas. Then, 2 rounds of review were conducted until all experts agreed on the themes and main issues arising using a nominal group technique to reach consensus. Prioritization was based on how useful the consensus recommendation might be to a policy maker. Findings: A diverse stakeholder group of 13 leaders in the fields of public health, digital health, and health care were engaged to reach a consensus on how to implement digital health recommendations to address the challenges of current and future pandemics. Participants reached a consensus on high-priority issues identified within 5 themes: team, transparency and trust, technology, techquity (the strategic development and deployment of technology in health care and health to achieve health equity), and transformation. Each theme contains concrete points of consensus to guide the local, national, and international adoption of digital health to address challenges of current and future pandemics. Conclusions and Relevance: The consensus points described for these themes provide a roadmap for the implementation of digital health policy by all stakeholders, including governments. Implementation of these recommendations could have a significant impact by reducing fatalities and uniting countries on current and future battles against pandemics.


Subject(s)
COVID-19 , Global Health/standards , Health Plan Implementation/standards , Pandemics , Telemedicine/standards , Consensus , Digital Technology/standards , Forecasting , Humans , SARS-CoV-2 , Stakeholder Participation
5.
Ann Thorac Med ; 15(4): 185-189, 2020.
Article in English | MEDLINE | ID: mdl-33381232

ABSTRACT

This article aims to shed light on the management that was taken by the King Saud Bin Abdulaziz University for Health Sciences to accommodate the immediate needs for online curriculum delivery, in response to the total lockdown due to COVID-19 pandemic. We have described the process done, actions implemented, and challenges faced to manage the curriculum delivery during the pandemic and to plan the subsequent year curriculum delivery. Effective management will be enhanced by focused faculty development, curriculum management, assessment planning, and technical support. We believe that the management done can be taken as a model in similar situations where sudden online curriculum delivery is deemed necessary. Further audit on the effectiveness and implication of these actions is required after the end of the pandemic.

7.
BMJ Open ; 9(5): e017476, 2019 05 05.
Article in English | MEDLINE | ID: mdl-31061009

ABSTRACT

OBJECTIVES: This study examines perceptions of the operational and organisational management of a major outbreak of Middle East Respiratory Syndrome (MERS) caused by a novel coronavirus (MERS-CoV) in the Kingdom of Saudi Arabia (KSA). Perspectives were sought from key decision-makers and clinical staff about the factors perceived to promote and inhibit effective and rapid control of the outbreak. SETTING: A large teaching tertiary healthcare centre in KSA; the outbreak lasted 6 weeks from June 2015. PARTICIPANTS: Data were collected via individual and focus group interviews with 28 key informant participants (9 management decision-makers and 19 frontline healthcare workers). DESIGN: We used qualitative methods of process evaluation to examine perceptions of the outbreak and the factors contributing to, or detracting from successful management. Data were analysed using qualitative thematic content analysis. RESULTS: Five themes and 15 subthemes were found. The themes were related to: (1) the high stress of the outbreak, (2) factors perceived to contribute to outbreak occurrence, (3) factors perceived to contribute to success of outbreak control, (4) factors inhibiting outbreak control and (5) long-term institutional gains in response to the outbreak management. CONCLUSION: Management of the MERS-CoV outbreak at King Abdulaziz Medical City-Riyadh was widely recognised by staff as a serious outbreak of local and national significance. While the outbreak was controlled successfully in 6 weeks, progress in management was inhibited by a lack of institutional readiness to implement infection control (IC) measures and reduce patient flow, low staff morale and high anxiety. Effective management was promoted by greater involvement of all staff in sharing learning and knowledge of the outbreak, developing trust and teamwork and harnessing collective leadership. Future major IC crises could be improved via measures to strengthen these areas, better coordination of media management and proactive staff counselling and support.


Subject(s)
Coronavirus Infections/prevention & control , Tertiary Care Centers , Adult , Aged , Disease Outbreaks/prevention & control , Female , Focus Groups , Hospital Administrators , Humans , Interviews as Topic , Male , Middle Aged , Personnel, Hospital , Saudi Arabia/epidemiology , Tertiary Care Centers/organization & administration
8.
Crit Rev Oncol Hematol ; 118: 70-78, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28917272

ABSTRACT

Efforts in colorectal cancer (CRC) research aim to improve early detection and treatment for metastatic stages which could translate into better prognosis of this disease. One of the major challenges that hinder these efforts is the heterogeneous nature of CRC and involvement of diverse molecular pathways. New large-scale 'omics' technologies are making it possible to generate, analyze and interpret biological data from molecular determinants of CRC. The developments of sophisticated computational analyses would allow information from different omics platforms to be integrated, thus providing new insights into the biology of CRC. Together, these technological advances and an improved mechanistic understanding might allow CRC to be clinically managed at the level of the individual patient. This review provides an account of the current challenges in CRC management and an insight into how new technologies could allow the development of personalized medicine for CRC.


Subject(s)
Colorectal Neoplasms/therapy , Precision Medicine , Colorectal Neoplasms/etiology , Colorectal Neoplasms/genetics , ErbB Receptors/antagonists & inhibitors , Genomics , Humans
9.
Int J Cancer ; 133(12): 2864-71, 2013 Dec 15.
Article in English | MEDLINE | ID: mdl-23740667

ABSTRACT

In this study, a cohort of 182 patients [55 hepatocellular carcinoma (HCC) and 127 non-HCC] infected with hepatitis B virus (HBV) in Saudi Arabia was investigated to study the relationship between sequence variation in the enhancer II (EnhII), basal core promoter (BCP) and precore regions of HBV genotype D (HBV/D) and the risk of HCC. HBV genotypes were determined by sequencing analysis and/or enzyme-linked immunosorbent assay. Variations in the EnhII, BCP and precore regions were compared between 107 non-HCC and 45 HCC patients infected with HBV/D, followed by age-matched analysis of 40 cases versus equal number of controls. Age and male gender were significantly associated with HCC (p = 0.0001 and p = 0.03, respectively). Serological markers such as aspartate aminotransferase, albumin and anti-HBe were significantly associated with HCC (p = 0.0001 for all), whereas HBeAg positivity was associated with non-HCC (p = 0.0001). The most prevalent HBV genotype was HBV/D (94%), followed by HBV/E (4%), HBV/A (1.6%) and HBV/C (0.5%). For HBV/D1, genomic mutations associated with HCC were T1673/G1679, G1727, C1741, C1761, A1757/T1764/G1766, T1773, T1773/G1775 and C1909. Age- and gender-adjusted stepwise logistic regression analysis indicated that mutations G1727 [odds ratio (OR) = 18.3; 95% confidence interval (CI) = 2.8-118.4; p = 0.002], A1757/T1764/G1766 (OR = 4.7; 95% CI = 1.3-17.2; p = 0.01) and T1773 (OR = 14.06; 95% CI = 2.3-84.8; p = 0.004) are independent predictors of HCC development. These results implicate novel individual and combination patterns of mutations in the X/precore region of HBV/D1 as predictors of HCC. Risk stratification based on these mutation complexes would be useful in determining high-risk patients and improving diagnostic and treatment strategies for HBV/D1.


Subject(s)
Carcinoma, Hepatocellular/virology , Enhancer Elements, Genetic , Hepatitis B virus/genetics , Liver Neoplasms/virology , Point Mutation , Promoter Regions, Genetic , Adolescent , Adult , Aged , Aged, 80 and over , Carcinoma, Hepatocellular/etiology , Child , Female , Genotype , Hepatitis B virus/classification , Humans , Liver Neoplasms/etiology , Logistic Models , Male , Middle Aged , Saudi Arabia
10.
Crit Care Med ; 41(2): 506-17, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23263618

ABSTRACT

OBJECTIVE: The effectiveness of rapid response teams remains controversial. However, many studied rapid response teams were not intensivist-led, had limited involvement beyond the initial activations, and did not provide post-ICU follow-up. The objective of this study was to examine the impact of implementing an intensivist-led multidisciplinary extended rapid response team on hospital-wide cardiopulmonary arrests and mortality. DESIGN: This was a pre-post rapid response team implementation study. SETTING: : Tertiary care academic center in Saudi Arabia. PATIENTS: A total of 98,391 patients in the 2-yr pre-rapid response team and 157,804 patients in the 3-yr post-rapid response team implementation were evaluated. INTERVENTION: The rapid response team was activated by any health care provider based on pre-defined criteria and a four-member intensivist-led multidisciplinary rapid response team responded to provide the necessary management and disposition. The rapid response team function was extended to provide follow-up until clinical stabilization. In addition, the rapid response team provided a mandatory post-ICU follow-up for a minimum of 48 hrs. MEASUREMENTS AND MAIN RESULTS: The primary outcomes were cardiopulmonary arrests and mortality. After rapid response team implementation, non-ICU cardiopulmonary arrests decreased from 1.4 to 0.9 per 1,000 hospital admissions (relative risk, 0.68; 95% confidence interval, 0.53-0.86; p = 0.001) and total hospital mortality decreased from 22.5 to 20.2 per 1,000 hospital admissions (relative risk, 0.90; 95% confidence interval, 0.85-0.95; p < 0.0001). For patients who required admission to the ICU, there was a significant reduction in the Acute Physiology and Chronic Health Evaluation II scores after rapid response team implementation from 29.3 ± 9.3 to 26.9 ± 8.5 (p < 0.0001), with reduction in hospital mortality from 57.4% to 48.7% (relative risk, 0.85; 95% confidence interval, 0.78-0.92; p < 0.0001). Do-not-resuscitate orders for ward referrals increased from 0.7 to 1.7 per 1,000 hospital admissions (relative risk, 2.58; 95% confidence interval, 1.95-3.42; p < 0.0001) and decreased for patients admitted to ICU from the wards from 30.5% to 26.1% (relative risk, 0.86; 95% confidence interval, 0.74-0.99; p = 0.03). Additionally, ICU readmission rate decreased from 18.6 to 14.3 per 100 ICU alive discharges (relative risk, 0.77; 95% confidence interval, 0.66-0.89; p < 0.0001) and post-ICU hospital mortality from 18.2% to 14.8% (relative risk, 0.85; 95% confidence interval, 0.72-0.99; p = 0.04). CONCLUSION: The implementation of rapid response team was effective in reducing cardiopulmonary arrests and total hospital mortality for ward patients, improving the outcomes of patients who needed ICU admission and reduced readmissions and mortality of patients who were discharged from the ICU.


Subject(s)
Heart Arrest/epidemiology , Hospital Rapid Response Team/organization & administration , Intensive Care Units , Medical Staff, Hospital , Patient Care Team/organization & administration , APACHE , Academic Medical Centers , Female , Hospital Mortality , Humans , Male , Middle Aged , Patient Admission , Patient Readmission/statistics & numerical data , Respiration, Artificial/statistics & numerical data , Resuscitation Orders , Tertiary Care Centers
11.
BMC Clin Pharmacol ; 11: 22, 2011 Dec 30.
Article in English | MEDLINE | ID: mdl-22208901

ABSTRACT

BACKGROUND: Clinical effects and outcomes of a single dose etomidate prior to intubation in the intensive care setting is controversial. The aim of this study is to evaluate the association of a single dose effect of etomidate prior to intubation on the mortality of septic cirrhotic patients and the impact of the subsequent use of low dose hydrocortisone. METHODS: This is a nested-cohort study within a randomized double blind placebo controlled study evaluating the use of low dose hydrocortisone in cirrhotic septic patients. Cirrhotic septic patients ≥ 18 years were included in the study. Patients who received etomidate prior to intubation were compared to those who did not receive etomidate for all cause 28-day mortality as a primary outcome. RESULTS: Sixty two intubated patients out of the 75 patients randomized in the initial trial were eligible for this study. Twenty three of the 62 intubated patients received etomidate dose prior to intubation. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality. CONCLUSIONS: In this group of septic cirrhotic patients with very high mortality, etomidate increased ICU mortality. Subsequent use of hydrocortisone appears to have no benefit beyond decreasing vasopressor requirements. The lowest mortality was observed in patients who did not receive etomidate but received hydrocortisone.


Subject(s)
Etomidate/administration & dosage , Fibrosis/drug therapy , Hydrocortisone/administration & dosage , Shock, Septic/drug therapy , Cohort Studies , Double-Blind Method , Etomidate/adverse effects , Female , Hospital Mortality , Humans , Intensive Care Units , Intubation/adverse effects , Intubation/methods , Male , Middle Aged , Shock, Septic/chemically induced , Treatment Outcome , Vasoconstrictor Agents/therapeutic use
13.
Liver Int ; 27(9): 1166-73, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17919227

ABSTRACT

Percutaneous liver biopsy (PLB) is the standard procedure for obtaining hepatic tissue for histopathological examination, and remains an essential tool in the diagnosis and management of parenchymal liver diseases. The use of liver biopsy (LB) is increasing with the advent of liver transplantation and the progress being made in antiviral therapeutic agents. While blind percutaneous needle biopsy is the traditional technique, the use of ultrasound (US) guidance has increased considerably. Literatures were reviewed to assess the existing clinical practice of PLB with an emphasis on the technique, the operator, types of biopsy needles, quality of LB specimens and the risk of complications. The best available evidence indicates that the use of ultrasound-guided biopsy (UGB) is superior to blind needle biopsy (BNB). The odds ratios of the controlled studies showed that BNB carried a higher risk for major complications, postbiopsy pain and biopsy failure. Therefore, percutaneous LB under US control is superior to BNB and it is recommended that UGB be considered the standard of care for this important and widely used invasive procedure in the field of clinical hepatology.


Subject(s)
Liver Diseases/pathology , Liver/pathology , Biopsy, Needle , Humans , Liver/diagnostic imaging , Ultrasonography
15.
Crit Care ; 10(4): 218, 2006.
Article in English | MEDLINE | ID: mdl-16834764

ABSTRACT

Whether it is the primary reason for admission or a complication of critical illness, upper gastrointestinal bleeding is commonly encountered in the intensive care unit. In this setting, in the absence of endoscopy, intensivists generally provide supportive care (transfusion of blood products) and acid suppression (such as proton pump inhibitors). More recently, octreotide (a somatostatin analogue) has been used in such patients. However, its precise role in patients with upper gastrointestinal bleeding is not necessarily clear and the drug is associated with significant costs. In this issue of Critical Care, two expert teams debate the merits of using octreotide in non-variceal upper gastrointestinal bleeding.


Subject(s)
Gastrointestinal Hemorrhage/drug therapy , Octreotide/therapeutic use , Gastrointestinal Hemorrhage/diagnosis , Gastrointestinal Hemorrhage/economics , Humans , Octreotide/economics
17.
Hepatol Res ; 24(2): 95, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12270737

ABSTRACT

We determined the hepatitis C virus (HCV) genotypes and the co-infection rate with hepatitis G (HGV) in 32 Arab patients infected with hepatitis C virus. Twenty two Saudi and ten Egyptian patients were recruited from southern Saudi Arabia, an endemic region for chronic liver disease. HCV genotype was determined by PCR with genotype specific primers in the core region. Hepatitis G virus RNA was detected by the reverse-transcription polymerase chain reaction (RT-PCR). Five patients were blood donors, 11 patients had chronic hepatitis C infection, 13 had cirrhosis and 3 had cirrhosis with hepatocellular carcinoma. HCV genotype 4 was detected in 11 of 22 Saudi patients (50%). HCV genotype 1b was detected in 9 Saudi patients (40.9%) and HCV genotype 1a was detected in 2 Saudi patients (9.1%). Amongst the 10 Egyptian patients, HCV genotype 4 was found in 9 patients (90%)) and genotype 1b in 1 patient (10%). The co-infection rate of HGV was 31% in patients with HCV infection. We conclude that HCV genotypes 4 and 1b are the major pathogenic strains, accounting for greater than 90% of HCV across ethnic groups in the southern region of Saudi Arabia. There was no significant association between HCV genotype, age and severity of liver disease. Co-infection with HGV is common and the significance is indeterminate.

18.
Saudi Med J ; 19(2): 215-216, 1998 Mar.
Article in English | MEDLINE | ID: mdl-27701595

ABSTRACT

Full text is available as a scanned copy of the original print version.

SELECTION OF CITATIONS
SEARCH DETAIL
...