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J Diabetes Complications ; 24(3): 179-85, 2010.
Article in English | MEDLINE | ID: mdl-19216096

ABSTRACT

BACKGROUND: We investigated the b-wave latency of electroretinogram (ERG), human basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), soluble fatty acid synthase (s-Fas), and adrenomedullin (ADM) in diabetic retinopathy. PATIENTS AND METHODS: Thirty control and 60 type II diabetic women (mean age 45+/-3.9 years, duration of diabetes 10.1+/-2.1 years) were investigated. Diabetics without complications (Group II) and with retinopathy (Group III) were diagnosed depending on clinical findings, abnormal fundus examination, and ERG. Plasma levels of b-FGF, VEGF, s-Fas, and ADM were measured. RESULTS: ERG showed a significant increase of b-wave absolute latency, plasma b-FGF, VEGF, s-Fas, and ADM in diabetic retinopathy (P<.05). A positive correlation was found between b-wave latency and VEGF and s-Fas, and a negative correlation with b-FGF and ADM. CONCLUSION: This study elucidates the causative role of VEGF and s-Fas in diabetic retinopathy. VEGF may potently promote growth of endothelial cells and formation of new vessels implicated in proliferative retinopathy. s-Fas could be involved in advancement of apoptotic changes in retinopathy and high levels of b-FGF, and ADM may be compensatorily neuroprotective and vasculoprotective. The results showed that diabetic retinopathy is the result of multiple factors, so it is optimistic to believe that reversing VEGF or s-Fas will halt retinopathy, targeting multiple mechanisms simultaneously by administering combination treatments of VEGF antagonists; antiapoptotic drugs together with b-FGF and/or ADM may be prospective.


Subject(s)
Adrenomedullin/blood , Diabetes Mellitus, Type 2/physiopathology , Diabetic Retinopathy/physiopathology , Fatty Acid Synthases/blood , Fibroblast Growth Factor 2/blood , Vascular Endothelial Growth Factors/blood , Adult , Blood Glucose/analysis , Diabetes Mellitus, Type 2/complications , Diabetic Retinopathy/blood , Electroretinography , Female , Humans , Middle Aged , Neovascularization, Physiologic
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