ABSTRACT
BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare, inherited disorder in which there is widespread and persistent infection by multiple subtypes of human papilloma virus, tinea versicolor-like lesions and plaques, and frequently malignant manifestations. MATERIALS AND METHODS: We report two cases of EV-a sister and brother aged 14 and 18 years respectively. Both had classical skin lesions together with neurological manifestations and deafness. In addition the man had plantar hyperkeratosis. They were treated with etretinate. CONCLUSIONS: PCR and DNA hybridization of skin lesions from the man contained HPV-20 and HPV-57. He was treated with long-term oral acitretin; the warty lesions became partly or wholly flattened and the plantar hyperkeratosis showed a remarkable improvement. The woman died 10 years later as a result of metastasizing breast cancer.
Subject(s)
Epidermodysplasia Verruciformis/pathology , Nervous System Diseases/etiology , Adolescent , Deafness/etiology , Epidermodysplasia Verruciformis/complications , Epidermodysplasia Verruciformis/virology , Humans , Male , Nervous System Diseases/pathology , Papillomaviridae/isolation & purification , Papillomavirus Infections/complications , Skin/pathology , Skin/virology , Speech Disorders/etiologyABSTRACT
Seven patients with xeroderma pigmentosum are presented. Abnormal karyotyping, found in one case, could be associated with an increased risk of the development of neoplasia.
Subject(s)
Skin Neoplasms/genetics , Xeroderma Pigmentosum/genetics , Child , Child, Preschool , Female , Humans , Karyotyping , Male , Pedigree , Skin Neoplasms/pathology , Xeroderma Pigmentosum/pathologyABSTRACT
A combination of both intralesional stibogluconate injection and superficial cryotherapy (not including the base of the lesion nor the 1-2 mm rim of the surrounding normal skin) was performed in an attempt to improve the therapeutic efficacy of either of the two modalities when used separately in the treatment of cutaneous leishmaniasis. This combined therapy resulted in a 100% cure rate in 15 patients with 23 lesions of cutaneous leishmaniasis. Two control groups, one treated with superficial cryo and the other treated with intralesional stibogluconate injection alone were included in the study for evaluation. The results obtained by combined superficial freezing and intralesional stibogluconate injection were much more impressive than those obtained by each of the two modalities when used alone.
