Profile of breast lesions among women with positive biopsy findings in Yemen.

This study described the profile of breast pathology based on records from a reference histopathology laboratory in Yemen of 773 women with positive biopsy or mastectomy findings. Cancers were classified according to the International classification of diseases for oncology. Benign lesions were found in 79.9% of cases. Fibroadenoma was the most prevalent lesion (30.0%) with a mean age at presentation of 22.2 years, followed by fibrocystic disease (27.4%) and breast inflammation (13.1%). Invasive carcinoma was found in 155 cases (20.1%), at a mean age of 44.7 years.

Profile of breast lesions among women with positive biopsy findings in Yemen

This study described the profile of breast pathology based on records from a reference histopathology laboratory in Yemen of 773 women with positive biopsy or mastectomy findings. Cancers were classified according to the International classification of diseases for oncology. Benign lesions were found in 79.9% of cases. Fibroadenoma was the most prevalent lesion [30.0%] with a mean age at presentation of 22.2 years, followed by fibrocystic disease [27.4%] and breast inflammation [13.1%]. Invasive carcinoma was found in 155 cases [20.1%], at a mean age of 44.7 years

The pattern and distribution of malignant neoplasms among Yemeni patients.

OBJECTIVE: This research was aimed at describing the pattern of malignancies among 1,491 patients during 1996 through to 2000 and to explore association with age, sex and site of cancers. METHODS: A research was carried out at a Histopathology Center in Sana'a, Republic of Yemen between the period August 1996 through to August 2000. All specimens were diagnosed by one pathologist based on the International Classification of Disease for Oncology. RESULTS: Results revealed comparable male: female ratio (1:0.92) and mean age of 46.1 +/- 22.8 in males and 44.2 +/-18.3. The most common cancers were the gastrointestinal tract malignancies, 22%. Lymph node cancers constituted 16%, followed by head and neck malignant tumors 12%, skin 10%, urinary tract 8%, bone and soft tissue 8%, breast 8%, female genital system 5%, thyroid gland 2% and finally male genital system, bone marrow and central nervous system/eye 2% each. For female patients breast cancers and gastrointestinal tract cancers were equally the most frequent malignancies. Skin cancers, followed by gastrointestinal tract and male genital system affected mostly older age patients. While bone marrow followed by central nervous system and eye, then bone and soft tissue cancers were mostly diagnosed in young age patients. Within the gastrointestinal tract liver was the most affected site 33% and adenocarcinomas were the most frequent diagnosed type 42%. Among lymph nodes malignancies non-Hodgkin's lymphoma constituted 42%. Oral cavity cancers constituted 73% of head and neck malignancies, where squamous cell carcinoma constituted 65%. CONCLUSION: Gastrointestinal tract in general with breast in females, were the most frequent sites of malignancies in the Republic of Yemen. Adenocarcinoma and squamous cell carcinoma were the most frequent types.

[Steroid hormone receptor status and other immunohistochemical prognostic markers in benign and malignant diseases of the breast]. / Steroidhormonrezeptorstatus und andere immunhistochemische Prognosemarker bei gut- und bösartigen Erkrankungen der Brustdrüse.

In addition to classical morphological prognosis factors of breast carcinoma (pTNM stage, tumor grading, histological typing), many other immunohistochemical markers of different prognostic value exist.--The comparative estrogen (ER) and progesterone receptor (PR) analysis of normal and pathological breast tissue showed a gradually inverse biological correlation between the decrease of ER+PR+ and the increase of ER-PR-frequency from benign breast changes to noninvasive and invasive breast carcinomas. In benign breast epithelium, ER+PR+ and ER-PR+ might be regarded as low-risk phenotype, whereas ER+PR- and ER-PR- could be estimated as high-risk phenotype in view of a later dedifferentiation and possible malignization.--During carcinogenesis, the initial loss of epithelial growth factor receptor (EGF-R) as well as its later neoexpression could be regarded as a progression maker.--The proliferation rate (Ki67) in breast cancer significantly correlates with increasing grading and apoptosis rate, whereas the expression of bcl-2-protooncogene is inverse to increasing grading. As for the prognostic value of the single factors, it is supposed that they mostly might represent "one piece of a larger puzzle" [13].