Association of reproductive factors with the incidence of breast cancer in Gulf Cooperation Council countries.

This article presents the incidence of female breast cancer in the Gulf Cooperation Council (GCC) countries and reviews the data in relation to established reproductive factors. Overall 4480 female breast cancer cases were diagnosed during 1998-2002 among GCC country nationals. Breast cancer was the most common malignancy in all GCC countries, ranging from 16.1% of female cancers in Oman to 35.4% in Bahrain. The age-standardized incidence rate per 100,000 was highest in Bahrain (46.4), followed by Kuwait (44.3), Qatar (35.5), United Arab Emirates (19.2), Oman (14.4) and Saudi Arabia (12.9). These rates are low compared with most industrialized countries.

Association of reproductive factors with the incidence of breast cancer in Gulf Cooperation Council countries

This article presents the incidence of female breast cancer in the Gulf Cooperation Council [GCC] countries and reviews the data in relation to established reproductive factors. Overall 4480 female breast cancer cases were diagnosed during 1998-2002 among GCC country nationals. Breast cancer was the most common malignancy in all GCC countries, ranging from 16.1% of female cancers in Oman to 35.4% in Bahrain. The age-standardized incidence rate per 100 000 was highest in Bahrain [46.4], followed by Kuwait [44.3], Qatar [35.5], United Arab Emirates [19.2], Oman [14.4] and Saudi Arabia [12.9]. These rates are low compared with most industrialized countries

Epidemiology of thyroid cancer: a review with special reference to Gulf Cooperation Council (GCC) states.

A wide variation in incidence of thyroid cancer according to age, sex, ethnicity and geographic region was observed. In general, it occurs more frequently in women than men and a substantially higher rate was observed particularly during fertile period of women compared with men of the same age. Papillary carcinoma is the most prevalent histological type, irrespective of gender and conditions like iodine level. Over the years the incidence of thyroid cancer, especially papillary type, increases around the world. Ionizing radiation, in particular radiotherapy to head and neck region was the most established risk factor for thyroid cancer. Goiter, miscarriage or abortion (particularly in the first pregnancy) may also predispose to thyroid cancer risk. Cigarette smoking and use of contraceptives may be modifier of thyroid cancer risk. In all the GCC states thyroid cancer is the second most common cancer except in Babrain and Kuwait (where it stands third). During the five year peribd (1998-2002) 549 male and 1898 female thyroid caneers were diagnosed in all the GCC states. Papillary carcinoma is the predominant histological type followed by follicular carcinoma in both genders. Among females, Qatar has the highest incidence with an age standardized incidence rate of 13.5 per 100,000 followed by Kuwait (7.7), Bahrain (7.6), Emirates (6.0), Oman (5.9), and Saudi Arabia (5.0). There were at least 2.6 female thyroid cancer cases (in Kuwait) for each male thyroid cancer case and this goes up to 6.6 in Babrain. Incidence of thyroid cancer in the GCC states is closer or higher than that of some of the developed countries.

An outbreak of food poisoning associated with restaurant-made mayonnaise in Abha, Saudi Arabia.

In May 1996, an outbreak of gastroenteritis occurred among customers who bought dinner from a restaurant that specialised in fried chicken in Abha city, south-west Saudi Arabia. The median incubation period was 10 hours (range: 3 to 27 hours). Of the 10 food items served, only mayonnaise (RR 2.52; 95% CI 1.71-3.73) and minced garlic (RR 1.20; 95% CI 1.02-1.41) were associated with cases. Salmonella enterica was isolated from 124 (84%) of the 159 persons with symptoms of food poisoning, and 91 (73%) were serogroup Enteritidis, phage type B 14. Mayonnaise was prepared in the restaurant using a regular blender. Minced garlic was prepared with the same blender immediately after making the mayonnaise. Unsafe storage of the mayonnaise at room temperature for a median of 6 hours could have resulted in overgrowth of bacteria and a high infective dose of bacteria per serving.

Chorea and high antiphospholipid antibodies: probable primary antiphospholipid syndrome.

A young man presented with generalized chorea as the first manifestation of probable primary antiphospholipid syndrome. He was well till 3 months before admission when he started to have involuntary, choreiform movements involving all extremities, the head and the bulbar muscles. Apart from these movements his physical examination was otherwise unremarkable. Laboratory investigations revealed mild thrombocytopenia, high partial thromboplastin time (PTT) only partially corrected by the addition of normal plasma, false positive syphilis serology, weakly positive antinuclear antibody and a high level of IgG anticardiolipin antibodies. Brain magnetic resonance imaging (MRI) showed multiple scattered small areas of high signal intensity on T2 weighted image in the area of centrum semiovale bilaterally. The patient was started on aspirin and prednisone with rapid symptomatic improvement. Despite the difficulty in proving the association between chorea and the high antiphospholipid antibodies, chorea appears in this case to be the initial symptom of primary antiphospholipid syndrome and we suggest screening for antiphospholipid antibodies in unexplained cases of chorea.