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Jpn J Infect Dis ; 64(1): 58-60, 2011.
Article in English | MEDLINE | ID: mdl-21266757

ABSTRACT

Panton-Valentine leukocidin (PVL) is a cytotoxin which causes leukocyte destruction and tissue necrosis. Although it is produced by fewer than 5% of Staphylococcus aureus strains, PVL-producing S. aureus is emerging as a serious problem worldwide. There has been a marked increase in the incidence of necrotizing lung infections with a very high mortality associated with these strains. This report describes a fatal case of hospital-acquired necrotizing pneumonia caused by PVL-positive methicillin-susceptible S. aureus in a patient with a brain tumor.


Subject(s)
Bacterial Toxins/biosynthesis , Cross Infection/microbiology , Exotoxins/biosynthesis , Leukocidins/biosynthesis , Pneumonia, Staphylococcal/microbiology , Staphylococcus aureus/metabolism , Adult , Anti-Bacterial Agents/pharmacology , Brain Neoplasms/complications , Fatal Outcome , Humans , Male , Methicillin/pharmacology , Microbial Sensitivity Tests , Pneumonia, Staphylococcal/pathology , Staphylococcal Infections/complications , Staphylococcal Infections/microbiology , Staphylococcus aureus/drug effects , Staphylococcus aureus/pathogenicity
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