Dextrose prolotherapy for pain and dysfunction of the TMJ reducible disc displacement: A randomized, double-blind clinical study.

To assess the efficacy of dextrose prolotherapy on the clinical signs and symptoms of patients having disc displacement with reduction (DDWR). This prospective, randomized, double-blind clinical study included thirty patients suffering from bilateral DDWR. The patients were randomly divided into two equal groups. After induction of local anesthesia, each joint was injected in two sites; one in the superior joint space and the other in the retrodiscal tissue, using 25% dextrose solution in group I and normal saline in group II. Pain intensity, maximal interincisal opening (MIO), and joint sounds (JS) were evaluated preoperatively, 1 week after each injection, and 3 months and 6 months after the last injection. Patients in group I showed significant improvement in pain and MIO, and higher satisfaction with treatment than patients in group II. Compared to saline injection, dextrose injection resulted in an improvement in JS but without significant difference within and between groups. Intra-articular injection of 25% dextrose is effective in the treatment of pain and dysfunction of TMJ DDWR as shown by significant improvement in pain and MIO and patient satisfaction. The technique is simple, easy to do, safe and should be adopted whenever appropriate.

Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats' critical-sized mandibular defects.

BACKGROUND: Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide. These defects generally result from severe trauma or resection of a whole large tumour. Autologous bone grafts are the current gold standard for the reconstruction of such defects. However, due to increased patient morbidity and the need for a second operative site, other lines of treatment should be introduced. To find alternative unconventional therapies to manage such defects, bone tissue engineering using a combination of suitable bioactive factors, cells, and biocompatible scaffolds offers a promising new approach for bone regeneration. AIM: To evaluate the healing capacity of platelet-rich fibrin (PRF) membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells (BMSCs) on critically sized mandibular defects in a rat model. METHODS: Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur. Rats were allocated to three equal groups of 21 rats each. Group I bone defects were irrigated with normal saline and designed as negative controls. Defects of group II were grafted with PRF membranes and served as positive controls, while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs. Seven rats from each group were killed at 1, 2 and 4 wk. The mandibles were dissected and prepared for routine haematoxylin and eosin (HE) staining, Masson's trichrome staining and CD68 immunohistochemical staining. RESULTS: Four weeks postoperatively, the percentage area of newly formed bone was significantly higher in group III (0.88 ± 0.02) than in groups I (0.02 ± 0.00) and II (0.60 ± 0.02). The amount of granulation tissue formation was lower in group III (0.12 ± 0.02) than in groups I (0.20 ± 0.02) and II (0.40 ± 0.02). The number of inflammatory cells was lower in group III (0.29 ± 0.03) than in groups I (4.82 ± 0.08) and II (3.09 ± 0.07). CONCLUSION: Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone.

Is the Anchored Disc Phenomenon a Truly Distinct Entity? A Systematic Review.

PURPOSE: This review aimed to examine whether the anchored disc phenomenon (ADP) is truly a distinct entity, independent of the closed-lock condition attributed to nonreducible disc displacement. MATERIALS AND METHODS: Clinical and/or diagnostic imaging studies addressing the anchored disc or ADP were considered. Articles eligible for inclusion were written in English; were conducted in humans; showed, in their titles or abstracts, any of the keywords used in the search method; included some type of disc imaging system; and related disc mobility to disc position. Of 18 potentially relevant articles, 10 were included. RESULTS: Of the studies, 9 used magnetic resonance imaging and 1 used double-contrast cone-beam computed tomography. In 1,691 joints, 270 discs (16%) were shown to be anchored in a normal (41%) or displaced (59%) position. Of 149 displaced anchored discs, 52 were reducible and 97 were nonreducible. Intra-articular adherences, synovitis, and adhesions were common arthroscopic findings in patients with the ADP. CONCLUSIONS: The temporomandibular joint anchored disc shown by disc imaging systems is worthy of inclusion in the existing categories of temporomandibular joint internal derangement. Classification of the ADP as a distinct entity still awaits a consensual definition of the problem, validation of the underlying hypothesis, and clarification of the natural history of the phenomenon.

Mandibular hypomobility after orthognathic surgery: a review article.

PURPOSE: To answer 2 specific questions in relation to mandibular hypomobility after orthognathic surgery (OGS): 1) Is hypomobility after OGS permanent? 2) Is there any underlying mechanism? MATERIALS AND METHODS: A Medline and PubMed search was performed to locate relevant articles. To meet inclusion in this review, articles were required to include patients with no pre-existing temporomandibular joint (TMJ) disorders who had been treated by the commonly performed OGS procedures. Case reports, pilot studies, and review articles were excluded. Twelve electronic search articles were identified. Manual search of the reference lists of these articles added another 11 articles. RESULTS: Of the 23 potentially relevant articles, 7 were considered eligible for inclusion. Five articles were retrospective and 2 were prospective. Vertical maxillary excess, Class II malocclusion, and Class III malocclusion were addressed in 344 patients who underwent Le Fort I maxillary osteotomy, sagittal split mandibular ramus osteotomy, or intraoral or extraoral vertical mandibular ramus osteotomy. Mandibular ramus surgeries were performed alone or in combination with Le Fort I osteotomy. Mandibular hypomobility, in terms of incisal range of motion, was measured with a ruler in 5 studies, with a Perspex triangular trismus gauge in 1 study, and with a jaw motion analyzer system in 1 study. Two studies reported permanent decreases in all ranges of mandibular motion 2 years after surgery and 5 studies did not support the notion that OGS affects mandibular mobility permanently. No mechanism for hypomobility after OGS was identified. CONCLUSION: Mandibular hypomobility after OGS is still in need of long-term prospective studies with homogenous patient samples of dentofacial deformities and the same TMJ conditions treated by the same experienced surgeon with adequate follow-up, internal controls, and blinding of examiners.

A review of techniques of lysis and lavage of the TMJ.

We systematically reviewed publications in the English language about techniques of lysis and lavage of the temporomandibular joint (TMJ). We describe these techniques and describe their advantages and disadvantages.

Mastication and late mandibular fracture after surgery of impacted third molars associated with no gross pathology.

PURPOSE: This study was undertaken with the null hypothesis that in patients, fully denate or with 1 or 2 teeth missing and older than 25 years, mastication does not affect late mandibular fracture after surgical removal of impacted third molars (M3s) associated with no gross pathology. MATERIALS AND METHODS: Five hundred sixty patients, fully dentate or with 1 or 2 teeth missing and older than 25 years who had no gross pathology associated with their impacted lower M3s, were recruited in this study. They were operated on under local anesthesia using a standard technique and randomly assigned into 2 groups for nonroutine (NR group) and routine (R group) postoperative instructions. In the NR group, patients were postoperatively educated in the possibility of mandibular fracture and were given an emphasis on the necessity of limiting mastication to a soft diet for 4 weeks. In the R group, patients were given no such education or emphasis. Patients were followed up for 2 months, and data concerning patients' age and gender; tooth position, angulation, and depth; date and site of surgery; and occurrence of late mandibular fracture were recorded and statistically analyzed. A value of P less than .05 was considered statistically significant. RESULTS: In no patient group was there a late mandibular fracture recorded. All patients completed the follow-up period, and most of the R group patients had normal eating habits 10 to 14 days after surgery. In no patient group was there a statistically significant difference in relation to gender (P = .735), site of surgery (P = .552), class horizontal space available (P = .427), class highest portion of the M3 crown (P = .424), angulations of the teeth (P = .925), and severity of impaction (P = .445). CONCLUSIONS: In patients, fully dentate or with 1 or 2 teeth missing and older than 25 years who have no jawbone atrophy and no systemic problems that may impair bone strength, mastication seems not to affect late mandibular fracture after surgical removal of impacted M3s associated with no gross pathology. The remote possible risk of the late fracture shown in our patients indicates the need for no special precautions.

A short period of maxillomandibular fixation for treatment of fractures of the mandibular tooth-bearing area.

PURPOSE: This study was aimed to determine whether a short period of maxillomandibular fixation (MMF) followed by an arch bar splint wired to the lower jaw is a suitable alternative to conventional MMF for treatment of fractures of the mandibular tooth-bearing area. PATIENTS AND METHODS: Thirty patients with mandibular fractures associated with no other facial fractures were selected. They were randomly assigned into 2 groups for treatment with conventional MMF (group A) and MMF for a short period of 2 weeks followed by an arch bar splint wired to the lower jaw (group B). Complications were recorded and post-treatment maximum interincisal mouth opening was measured at 1 week and 3 and 6 months. Age and gender-matched control groups were randomly selected. Groups were then compared for significant differences. A value of P < .05 was considered significant. RESULTS: The 2 patient groups were not significantly different in relation to site and cause of fracture (P =.995 and P = .682, respectively), the mean time from injury to MMF (P = .234), and the mean time required for fracture healing (P = .315). Delayed union and nonunion were not encountered, and there were no significant differences in relation to postoperative infection ( P = 1) and malocclusion (P = .598). When compared with group A patients, group B patients had an early significantly greater degree in mouth opening (P = .001); at no time was there a significant difference in the degree of mouth opening between group B patients and the control group (1 week, P = .079; 3 months, P = .166; 6 months, P = .378). CONCLUSION: In selected cases, a short period of MMF followed by an arch bar splint wired to the lower jaw is a suitable alternative to conventional MMF for treatment of fractures of the mandibular tooth-bearing area. The method is effective and significantly reduces the potential adverse effects of long-term MMF.

Ultrasound-guided drainage of submasseteric space abscesses.

PURPOSE: The oral approach for incision and drainage (I and D) in patients presenting with submasseteric space (SMS) abscesses and marked trismus is more difficult and requires a general anesthetic, necessitating an anesthetist experienced in fiberoptic-guided nasal intubation. In such patients, ultrasound-guided drainage (USGD) has been attempted to obviate this need. The purpose of this trial was to report our experience with the surgical management of 11 SMS abscesses, with special reference to their USGD. MATERIALS AND METHODS: Seven men and 4 women ranging in age from 18 to 41 years (average age, 25 years) participated in this trial. They were initially examined with US, and their abscesses were subsequently drained under US guidance using a 16-gauge intravenous catheter. An antibiotic regimen was prescribed, and arrangements were made to see the patients daily for 5 days. USGD was repeated after 24 hours, and 24 hours later the infection course was monitored in each patient. Patients with nonresolving infection had their abscesses formally incised and drained extraorally. The source of infection was removed as soon as the acute phase of infection passed and the interincisal opening (IIO) allowed. The catheter or corrugated drain was removed when the discharge ceased or became minimal. Patients were then instructed to continue a 3-day course of an antibiotic and to return after 1 week and then after 1 month. RESULTS: Resolution of infection was successfully achieved by USGD with no need for I and D in 8 of the 11 patients (73%). In those patients, the average total amount of pus removed was 8.5 mL, and the average IIO was 17.4 mm immediately after an average initial aspirate of 4.5 mL of pus. I and D was required in the remaining 3 patients (27%). In those patients the average total amount of pus removed was 17.5 mL, and the average IIO was 7.7 mm immediately after an average initial aspirate of 9.3 mL of pus. CONCLUSIONS: Resolution of infection with USGD is more probable if there was an immediate improvement of the IIO to about 1.5 cm or more after an initial aspiration of 5 mL of pus.

Inferior meatal antrostomy: is it necessary after radical sinus surgery through the Caldwell-Luc approach?

PURPOSE: In the Caldwell-Luc (CWL) operation, an antrostomy at the inferior meatus is created surgically to promote sinus drainage. This inferior meatal antrostomy (IMA) has been criticized because of the need for an additional time, early loss of the sinusotomy, injury to the nasolacrimal duct, epistaxis from the sphenopalatine artery, and deviation from the normal sinus physiology. This trial was undertaken with specific attention to the question: Is it necessary to perform antrostomy at the inferior meatus after radical sinus surgery through the CWL approach? MATERIALS AND METHODS: Thirty-three patients with a dental origin of sinus disease indicating the CWL operation were entered into this trial. They were treated in blocks of 3, in which IMA was not performed in the first and second patients of each successive block. Only the third patient of each block had IMA performed. Cheek swelling, infection, and failure to relieve the patient's symptoms were the criteria for comparison between patient groups. Cheek swelling was measured by the eye-mouth line and the ear-nose line on the second and fourth day after surgery. RESULTS: At no time was there a statistically significant difference in cheek swelling between the treated groups (P >.05). No infection or failure of treatment was encountered. However, some patients in both groups had numbness or paresthesias of the cheek, upper lip, upper front gingiva, and teeth. These complaints were transient and lasted for several weeks. CONCLUSION: Based on our findings, it does not seem necessary to perform antrostomy at the inferior meatus, provided the patient has a patent osteomeatal complex and no anatomic abnormalities.

The relationship of "shisha" (water pipe) smoking to postextraction dry socket.

PURPOSE: This study was undertaken to determine whether "shisha" (water pipe) smokers (SS) were at a different risk of developing dry socket (DS) than were cigarette smokers (CS) or nonsmokers (NS) and to assess the effect of preoperative and postoperative smoking habits on the incidence of DS. MATERIALS AND METHODS: One hundred NS, 100 CS, and 100 SS were enrolled. Surgery for removal of mandibular third molars was performed under local anesthesia with no incision or bone removal. At 1, 4, and 7 days after surgery, postoperative evaluation and postoperative smoking were recorded by the same examiner. The chi(2) test was used for statistical analysis of results. Statistical significance was defined as a value of P <.05. RESULTS: Smokers had 2 to 3 times the risk of NS for developing DS. Although SS had a greater incidence of DS than did CS, the difference was not significant (P =.083). The incidence of DS was not age dependent. Smokers who smoked the day of surgery had a significantly higher incidence of DS than did smokers who smoked the second day after surgery. Compared with NS, CS who smoked the day of surgery and SS who smoked the day of surgery or the first day after surgery had a significantly increased incidence of DS (CS/NS, day 0, P =.001; SS/NS, day 0, P =.001; day 1, P =.005). CONCLUSION: SS had 3 times the risk of NS for developing DS, but there was no statistically significant difference between SS and CS. Increased frequency of smoking and smoking during the day of surgery significantly increased the incidence of DS.

Hemostatic effect of n-butyl-2-cyanoacrylate (histoacryl) glue in warfarin-treated patients undergoing oral surgery.

PURPOSE: Our goal was to evaluate the local hemostatic effect of n-butyl-2-cyanoacrylate (Histoacryl; B. Braun, Melsungen, Germany) glue in warfarin-treated patients who undergo outpatient oral surgery without a change in their level of anticoagulation. MATERIALS AND METHODS: Thirty consecutive warfarin-treated patients randomly assigned to study and control groups and 10 patients who had never been on anticoagulant therapy serving as the negative control group were included in this trial. Before multiple teeth extractions, all patients had a prothrombin time and the international normalized ratio (INR) determined. To gain hemostasis and primary closure, gelatin sponge and multiple interrupted resorbable sutures were used in the control and negative control groups, and Histoacryl glue and the minimal number of interrupted resorbable sutures were used in the study group. Postoperatively, patients were to contact the oral surgeon if abnormal bleeding occurred. Patients who did not have postoperative bleeding were seen on the 10th postoperative day. Data were collected, and statistical differences in age and gender distributions, number of teeth extracted, INR levels, and bleeding that required treatment were analyzed with the Mantel-Haenzel test. Statistical significance was defined as a value of P <.05. RESULTS: Local hemostasis was obtained immediately in study patients and only after 10 to 20 minutes in the control and negative control patients. In relation to bleeding complications, there were no cases of postoperative bleeding requiring treatment in both the negative control patients and study patients. In the control patients, 5 cases had postoperative spontaneous bleeding that required treatment. This difference was statistically significant. No patient had wound infection and the healing process appeared to be normal. CONCLUSION: Multiple extractions can be performed in patients taking oral anticoagulant therapy without a change in their level of anticoagulation provided an efficient local hemostatic measure is instituted. And, in this regard, Histoacryl glue, used as a topical adhesive over approximated wound edges, is an effective and easily applicable local hemostatic for oral surgery in such patients.

The efficacy of azithromycin in the treatment of acute infraorbital space infection.

PURPOSE: In this study, we aimed to evaluate the role of azithromycin in the treatment of acute infraorbital space infection. MATERIALS AND METHODS: Sixty patients (39 men and 21 women; age range, 18 to 47 years) who had acute infraorbital space infection with pain, swelling, and general malaise were included in the study. After initial surgical therapy, patients were randomly allocated to receive either 500 mg azithromycin once daily for 3 days, 250 mg erythromycin stearate every 6 hours for 3 days, or no antibiotic. Patients were assessed at the time of admission and after 1, 2, 3, and 7 days. Pain, swelling, cervical lymphadenopathy, and sublingual temperature were assessed at each visit. Data were collected, and all groups were compared for differences in pain and swelling using the Mann-Whitney U test and for differences in lymphadenopathy and sublingual temperature using Fisher's exact test. RESULTS: At the time of admission, no 2 groups were statistically different at the.05 level in relation to age, gender, and presenting clinical signs or symptoms. At days 2 and 3, patients who received azithromycin had a significant reduction in pain (P =.002 and P =.02, respectively) and swelling (P =.001 and P =.013, respectively) compared with those who received no antibiotic. At day 3, patients who received erythromycin had a significant reduction in pain (P =.03) and swelling (P =.046) compared with those who received no antibiotic. In a comparison of the patients who received azithromycin with those who received erythromycin, there was no significant difference (P >.05) in the reduction of pain at any time of the study. However, at day 2, patients who received azithromycin had a significantly greater reduction in swelling (P =.002) than those who received erythromycin. In relation to the percentage of the patients with cervical lymphadenopathy and raised sublingual temperature (>37.2 degrees C), no 2 groups were statistically different at any time of the study. After 3 days of treatment, patients who received the antibiotics were clinically improved, and all patients (n = 60 patients) reviewed after 7 days had resolution of their clinical signs and symptoms. CONCLUSION: This study emphasizes the importance of surgical drainage and proves that both azithromycin and erythromycin are effective adjunctive treatments in the therapy of relatively mild odontogenic orofacial infections.