Education and electronic medical records and genomics network, challenges, and lessons learned from a large-scale clinical trial using polygenic risk scores.

Polygenic risk scores (PRS) have potential to improve health care by identifying individuals that have elevated risk for common complex conditions. Use of PRS in clinical practice, however, requires careful assessment of the needs and capabilities of patients, providers, and health care systems. The electronic Medical Records and Genomics (eMERGE) network is conducting a collaborative study which will return PRS to 25,000 pediatric and adult participants. All participants will receive a risk report, potentially classifying them as high risk (∼2-10% per condition) for 1 or more of 10 conditions based on PRS. The study population is enriched by participants from racial and ethnic minority populations, underserved populations, and populations who experience poorer medical outcomes. All 10 eMERGE clinical sites conducted focus groups, interviews, and/or surveys to understand educational needs among key stakeholders-participants, providers, and/or study staff. Together, these studies highlighted the need for tools that address the perceived benefit/value of PRS, types of education/support needed, accessibility, and PRS-related knowledge and understanding. Based on findings from these preliminary studies, the network harmonized training initiatives and formal/informal educational resources. This paper summarizes eMERGE's collective approach to assessing educational needs and developing educational approaches for primary stakeholders. It discusses challenges encountered and solutions provided.

Improving the performance of air conditioning unit by using a hybrid technique.

An Air Conditioning Unit with magnetic field and different tubes was designed, fabricated and evaluated in this study. The Effect of magnetic field and different types of tubes on the performance of Air Conditioning was studied experimentally. A testing system of Air Conditioning Unit was developed as the test rig. The modified tubes as a straight tube before the condenser and after the evaporator were replaced by a finned bended tube with five bends and a coil finned tube with five turns. The experimental results for the temperature of refrigerant and the coefficient of performance for an air conditioning unit were presented. Changing the tubes and introducing electric charging has a significant effect on the performance of the unit. The electric charging has a positive effect of the performance of the system. The electric charging enhanced the performance by 76% in case of bent tube and by 177% in case of coil tube. The bent pipe increases the refrigerant temperature between 50% and 200%, while the coil pipe increases the temperature between 18 % and 190 %. • This method increases the refrigerant temperature for Air Conditioning system. • This method provides simple technical testing of Air Conditioning Unit with magnetic field and different tubes • This method can be useful to enhance the performance of Air Conditioning Unit.