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1.
Neuropsychiatr Dis Treat ; 12: 1943-51, 2016.
Article in English | MEDLINE | ID: mdl-27536117

ABSTRACT

Previous studies carried out in Euro-American populations have unequivocally indicated that psychological disorders of the CASD (caregivers of children with autism spectrum disorder) are marked with high levels of stress, anxiety, and depression. This finding has been attributed to the reaction of having to care for a child with neurodevelopmental disorders. While there have been reports on autism spectrum disorder in Arab/Islamic countries such as Oman, there is no study from this region, to our knowledge, reporting the performance of indices of stress, anxiety, and depression among CASD. This study aimed to examine whether there is variation in the performance of indices of stress, depression, and anxiety explored via Depression, Anxiety and Stress Scale 21 among CASD, caregivers of children with intellectual disabilities, and caregivers of typically developing children. All indices of stress, depression, and anxiety were higher in CASD compared to other caregivers in the control group. This study corroborates with other studies carried out in other populations that caring for children impacts the mental health status of caregivers. Therefore, there are strong grounds to contemplate the mechanism to help such a vulnerable group of family caregivers.

2.
Sultan Qaboos Univ Med J ; 15(2): e213-7, 2015 May.
Article in English | MEDLINE | ID: mdl-26052454

ABSTRACT

Epidemiological surveys from various countries indicate an increased prevalence of autism spectrum disorders (ASD), leading researchers to debate whether there are now 'more affected' or 'more detected'. The epidemiology of ASD in developing countries, such as Oman, has generally indicated a lower prevalence compared to developed countries in the West. In Oman, the prevalence is low; however, this article highlights some of the factors that could contribute to the appearance of a low ASD rate: cross-cultural variations in the presentation of distress; a lack of reliable biological markers for diagnosing ASD, and a lack of health services for children with ASD, thus limiting the number of participants in epidemiological surveys. While the defining features of ASD have yet to be established, pilot studies in Oman indicate a substantial number of children with these disorders. Therefore, it is important that these discrepancies be addressed and the need for appropriate services for this patient population in Oman be highlighted.

3.
Autism ; 19(1): 6-13, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24151129

ABSTRACT

Children with special needs such as those with autism spectrum disorder have been recorded as ostracized and stigmatized in many parts of the world. Little is known about whether such negative views are present among mainstream teachers in Oman. A cross-sectional study was conducted to evaluate school teachers' awareness about autism spectrum disorder in an urban region in Oman. A total of 164 teachers were randomly enrolled from five schools. Misconceptions about autism spectrum disorder were found to be common among mainstream teachers in the country. We posit that such lack of awareness was likely to be rooted with sociocultural patterning as well as conflicting views often "spun" by the scientific community and mass media. Enlightened views toward children with autism spectrum disorder should be presented to Omani teachers to overcome misconceptions and negative attitudes toward children with autism spectrum disorder.


Subject(s)
Autistic Disorder , Faculty , Health Knowledge, Attitudes, Practice , Adult , Child Development Disorders, Pervasive , Cross-Sectional Studies , Female , Humans , Mainstreaming, Education , Male , Middle Aged , Oman , Social Stigma , Surveys and Questionnaires , Young Adult
4.
BMC Public Health ; 14: 380, 2014 Apr 17.
Article in English | MEDLINE | ID: mdl-24742222

ABSTRACT

BACKGROUND: Despite that hereditary diseases are widespread among the Arab population due to high rates of consanguineous marriages, research regarding community awareness towards premarital carrier screening in some countries such as Oman, is extremely scarce. This study aimed to investigate knowledge and attitude towards premarital carrier screening (PMCS) in Oman. METHODS: A cross-sectional study was conducted using a self-administered questionnaire which was distributed to 400 Omani adults aged 20-35 who attended primary healthcare institutions at the South Batinah Governorate in Oman. RESULTS: The majority of the participants (84.5%) believed that PMCS was necessary, and about half of them (49.5%) supported the view of making PMCS compulsory. On the contrary, approximately one third (30.5%) of the participants reported that they were not in favor of taking the blood screening test. Overall, unwillingness to perform pre-marital testing was associated with female gender, younger age, being single, less education, and increased income. CONCLUSION: Despite the relatively high level of knowledge, about one third of the participants were still reluctant to carry out premarital testing. Such attitude calls for immediate need for community-based campaigns to encourage the public to do premarital testing.


Subject(s)
Awareness , Consanguinity , Genetic Testing , Health Knowledge, Attitudes, Practice , Marriage , Adult , Age Factors , Aged , Arabs , Cross-Sectional Studies , Family , Female , Humans , Male , Oman , Patient Acceptance of Health Care , Primary Health Care , Sex Factors , Socioeconomic Factors , Surveys and Questionnaires , Young Adult
5.
Exp Biol Med (Maywood) ; 239(6): 697-706, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24676906

ABSTRACT

Genetic, nutrition, and environmental factors have each been implicated as sources of risk for autism. Oxidative stress, including low plasma levels of the antioxidant glutathione, has been reported by numerous autism studies, which can disrupt methylation-dependent epigenetic regulation of gene expression with neurodevelopmental consequences. We investigated the status of redox and methylation metabolites, as well as the level of protein homocysteinylation and hair mercury levels, in autistic and neurotypical control Omani children, who were previously shown to exhibit significant nutritional deficiencies in serum folate and vitamin B12. The serum level of glutathione in autistic subjects was significantly below control levels, while levels of homocysteine and S-adenosylhomocysteine were elevated, indicative of oxidative stress and decreased methionine synthase activity. Autistic males had lower glutathione and higher homocysteine levels than females, while homocysteinylation of serum proteins was increased in autistic males but not females. Mercury levels were markedly elevated in the hair of autistic subjects vs. control subjects, consistent with the importance of glutathione for its elimination. Thus, autism in Oman is associated with decreased antioxidant resources and decreased methylation capacity, in conjunction with elevated hair levels of mercury.


Subject(s)
Autistic Disorder/metabolism , Glutathione/metabolism , Hair/metabolism , Malnutrition/metabolism , Mercury/metabolism , 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/metabolism , Autistic Disorder/epidemiology , Autistic Disorder/etiology , Child , Child, Preschool , Female , Humans , Male , Malnutrition/complications , Malnutrition/epidemiology , Oman , Oxidative Stress , S-Adenosylmethionine/metabolism
6.
Nutrition ; 29(9): 1142-6, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23800562

ABSTRACT

OBJECTIVES: Autism is a lifelong neurodevelopmental disorder of early childhood. Dietary supplementation of the ω-3 fatty acid (docosahexaenoic acid [DHA]) during prenatal and postnatal life is considered a protective dietary intervention strategy to minimize the risk for autism spectrum disorder (ASD). To our knowledge, no relevant studies have been conducted in the Middle East investigating the status of DHA among children with autism during early childhood. The aim of this study was to investigate the serum levels and dietary intake status of DHA among Omani children recently diagnosed with ASD. METHODS: The present case-control study involved 80 Omani children (<5 y), 40 cases and 40 controls matched for age and sex. A semi-quantitative food frequency questionnaire was used to assess dietary intake of all the participants, while serum levels of DHA were measured using high-performance liquid chromatography. RESULTS: Our results showed that children with ASD had lower dietary consumption of foodstuff containing DHA, as well as lower serum levels of DHA than controls. CONCLUSION: The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.


Subject(s)
Autistic Disorder/blood , Dietary Supplements , Docosahexaenoic Acids/administration & dosage , Docosahexaenoic Acids/blood , Feeding Behavior , Nutritional Status , Autistic Disorder/diet therapy , Case-Control Studies , Child, Preschool , Humans , Oman
7.
Nutrition ; 29(3): 537-41, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23287069

ABSTRACT

OBJECTIVE: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. METHODS: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). RESULTS: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. CONCLUSION: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.


Subject(s)
Autistic Disorder/complications , Diet , Folic Acid Deficiency/complications , Vitamin B 12 Deficiency/complications , Case-Control Studies , Child, Preschool , Female , Folic Acid/administration & dosage , Folic Acid/blood , Folic Acid Deficiency/epidemiology , Homocysteine/blood , Humans , Male , Nutrition Assessment , Nutritional Status , Odds Ratio , Oman/epidemiology , Vitamin B 12/administration & dosage , Vitamin B 12/blood , Vitamin B 12 Deficiency/epidemiology
8.
J Autism Dev Disord ; 43(5): 1214-21, 2013 May.
Article in English | MEDLINE | ID: mdl-23001768

ABSTRACT

A cross-sectional study was conducted to investigate whether caregiver's variations in socioeconomic status (SES) has direct bearing on challenges of nurturing children with autism spectrum disorder (ASD) in Oman. A cadre of caregivers (n = 150) from two types of SES (low-income and middle-high income) were compared based on four domains: (1) accessing and perception of remedial services, (2) utilization and perception of psychiatric services, (3) constraints for being a caregiver of children with ASD and (4) financial expenses of taking care of children with ASD. There is little indication that any particular SES fare well on these domains. Factors to mitigate such predicaments are therefore imperative in order to improve quality of life for caregivers among children with ASD.


Subject(s)
Caregivers/psychology , Child Development Disorders, Pervasive/economics , Cost of Illness , Health Services Accessibility , Quality of Life , Adolescent , Adult , Child , Child, Preschool , Cross-Sectional Studies , Female , Humans , Male , Oman , Social Class , Surveys and Questionnaires
9.
Biol Trace Elem Res ; 151(2): 181-6, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23188679

ABSTRACT

Toxic levels of heavy metals and low levels of essential minerals have been suggested to play a critical role in the pathogenesis of autism spectrum disorders (ASD). This study documents the levels of heavy metals and essential minerals in hair samples of children with ASD in Muscat, the urbanized capital of Oman, Muscat. The study included 27 children with ASD and 27 matched non-ASD controls. Parental interviews were held and dietary intake questionnaires completed in conjunction with the collection of hair samples. Analysis of heavy metals and essential minerals was carried out by inductively coupled plasma mass spectrometry. Chi-square analysis and non-parametric Fisher's exact tests were used to assess statistical significance. Children with ASD had significantly higher levels of all 11 analyzed heavy metals in their hair samples (P < 0.05), ranging from 150 to 365 % of control levels. ASD children also had significantly higher levels of essential minerals sulfur, sodium, magnesium, potassium, zinc, and iron, but lower levels of calcium and copper in their hair samples. This study corroborates data from previous studies in different parts of the world indicating the presence of elevated levels of heavy metals and selective depletion of essential minerals in the hair of children with ASD.


Subject(s)
Child Development Disorders, Pervasive/pathology , Hair/chemistry , Metals, Heavy/analysis , Minerals/analysis , Calcium/chemistry , Case-Control Studies , Chi-Square Distribution , Child , Child, Preschool , Female , Humans , Male , Mass Spectrometry , Metals, Heavy/chemistry , Minerals/chemistry , Oman , Potassium/chemistry , Sodium/chemistry , Sulfur/chemistry , Surveys and Questionnaires
10.
Nutrition ; 28(7-8): e27-32, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22541054

ABSTRACT

OBJECTIVE: To evaluate the association between suboptimal breast-feeding practices and autism spectrum disorders (ASDs). METHODS: A case-control study was conducted in 102 ASD cases and 102 matched healthy controls. RESULTS: Based on adjusted odds ratios from logistic regression models, ASD was found to be associated with the late initiation of breast-feeding (odds ratio 1.48, 95% confidence interval 1.01-3.1), a non-intake of colostrum (odds ratio 1.7, 95% confidence interval 1.03-4.3), prelacteal feeding, and bottle-feeding. The risk of ASD was found to decrease in a dose-response fashion over increasing periods of exclusive breast-feeding (P for trend = 0.04) and continued breast-feeding (P for trend = 0.001). CONCLUSION: The study indicates that increased ASD risk is generally associated with suboptimal breast-feeding practices.


Subject(s)
Breast Feeding , Child Development Disorders, Pervasive/epidemiology , Child Development , Adolescent , Breast Feeding/ethnology , Case-Control Studies , Child , Child Development Disorders, Pervasive/ethnology , Child Health Services , Child, Preschool , Colostrum , Diagnostic and Statistical Manual of Mental Disorders , Female , Hospitals, University , Humans , Logistic Models , Male , Oman/epidemiology , Outpatient Clinics, Hospital , Pilot Projects , Risk , Surveys and Questionnaires
11.
J Autism Dev Disord ; 41(6): 821-5, 2011 Jun.
Article in English | MEDLINE | ID: mdl-20809376

ABSTRACT

Prevalence of autistic spectrum disorders (ASD) in Oman is unknown. We conducted a cross-sectional study to estimate the prevalence of ASD among 0-14 year old children. Diagnoses were made as per DSM-IV-TR criteria and supplemented with information collected with the standard Childhood Autism Rating Scale (CARS) questionnaire. A total 113 cases of ASD were enumerated nationwide, indicating an overall prevalence of 1.4 (95% CI 1.2, 1.7) cases per 10,000 children aged 0-14 years. More prevalent cases were among boys (75%) and among low-income families. Ritualistic interests were more common among girls as an onset-symptom compared to boys (p = 0.03). The reported low prevalence of ASD in Oman is likely due to under-diagnosis and under-reporting.


Subject(s)
Autistic Disorder/diagnosis , Autistic Disorder/epidemiology , Adolescent , Child , Child, Preschool , Cross-Sectional Studies , Diagnostic and Statistical Manual of Mental Disorders , Female , Humans , Infant , Male , Oman/epidemiology , Prevalence
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