ABSTRACT
BACKGROUND: The role of diastolic blood pressure (DBP) with cognitive functioning is under-explored in relation to levels of systolic blood pressure (SBP). METHODS: We studied 5466 participants from the National Health and Nutrition Examination Survey. Blood pressure was measured 3 times manually with a standardized sphygmomanometer and averaged. Cognitive functioning was measured using the digit symbol substitution test (DSST). RESULTS: Participants were 60 years or older, 55% female, and 81% non-Hispanic White. Most participants had a DBP between 70 to <80 mmHg (33.7%), between 60 to <70 mmHg (29.3%), or <60 mmHg (18.8%). From multivariable linear regression analyses, each 5 mmHg increment of DBP was associated with significantly higher DSST scores among individuals with SBP <120 only (ß: 0.56, 95% CI: 0.09, 1.03). CONCLUSIONS: Among older US adults, at non-elevated levels of SBP, higher DBP is associated with better cognitive performance.
Subject(s)
Hypertension , Humans , Adult , Female , Middle Aged , Aged , Male , Blood Pressure/physiology , Nutrition Surveys , Cognition/physiologyABSTRACT
PURPOSE: Migrating from Mexico to the U.S. is a major, stressful life event with potentially profound influences on mental health. However, estimating the health effects of migration is challenging because of differential selection into migration and time-varying confounder mediators of migration effects on health. METHODS: We pooled data from the Mexican Health and Aging Study (N = 17,771) and Mexican-born U.S. Health and Retirement Study (N = 898) participants to evaluate the effects of migration to the U.S. (at any age and in models for migration in childhood or adulthood) on depressive symptom-count, measured with a modified Centers for Epidemiologic Studies-Depression scale. We modeled probability of migrating in each year of life from birth to either age at initial migration to the U.S. or enrollment and used these models to calculate inverse probability of migration weights. We applied the weights to covariate-adjusted negative binomial GEE models, estimating the ratio of average symptom-count associated with migration. RESULTS: Mexico to U.S. migration was unrelated to depressive symptoms among men (ratio of average symptom-count= 0.98 [95% CI: 0.89, 1.08]) and women (ratio of average symptom-count = 1.00 [95% CI: 0.92, 1.09]). Results were similar for migration in childhood, early adulthood, or later adulthood. CONCLUSIONS: In this sample of older Mexican-born adults, migration to the U.S. was unrelated to depressive symptoms.
Subject(s)
Aging , Depression , Adult , Depression/epidemiology , Female , Humans , Male , Mexico/epidemiology , Models, Statistical , RetirementABSTRACT
OBJECTIVE: The objective of the study is to evaluate the association of intergenerational educational attainment with cardiovascular disease (CVD) risk factors among US Latinos. METHODS: We used cross-sectional data from the Niños Lifestyle and Diabetes Study, an offspring cohort of middle-aged Mexican-Americans whose parents participated in the Sacramento Latino Study on Aging. We collected educational attainment, demographic and health behaviours and measured systolic blood pressure (SBP), fasting glucose and waist circumference. We evaluated the association of parental, offspring and a combined parent-offspring education variable with each CVD risk factor using multivariable regression. RESULTS: Higher parental education was associated only with smaller offspring waist circumference. In contrast, higher offspring education was associated with lower SBP, fasting glucose and smaller waist circumference. Adjustment for parental health behaviours modestly attenuated these offspring associations, whereas adjustment for offspring health behaviours and income attenuated the associations of offspring education with offspring SBP and fasting glucose but not smaller waist circumference, even among offspring with low parental education. CONCLUSIONS: Higher offspring education is associated with lower levels of CVD risk factors in adulthood, despite intergenerational exposure to low parental education.
Subject(s)
Antineoplastic Agents, Alkylating/adverse effects , Hematopoietic Stem Cell Mobilization/methods , Melphalan/adverse effects , Multiple Myeloma/blood , Multiple Myeloma/drug therapy , Stem Cell Transplantation/methods , Aged , Antineoplastic Agents, Alkylating/administration & dosage , Blood Component Removal/methods , Humans , Melphalan/administration & dosage , Middle Aged , Salvage TherapyABSTRACT
The risk of hypothyroidism after reduced-intensity hematopoietic cell transplantation (HCT) is not well known. We studied the incidence of hypothyroidism among a cohort of HCT recipients who had survived for > or =1 year and received a TBI-based myeloablative (MA) (N=84) or reduced-intensity (N=97) conditioning (RIC) regimen. MA HCT recipients were younger at the time of transplant (median age 37 vs 54 years, P<0.01), otherwise the two groups were comparable. Median follow-up was 28 (range, 12-75) months for MA and 25 (range, 12-67) months for RIC group. The 3-year cumulative incidence of hypothyroidism was 8 and 5%, respectively (P=0.41). In multivariate analysis, both types of conditioning regimens were associated with similar risks for hypothyroidism (relative risk for MA 1.6 vs RIC). At least in the first few years after HCT, the risks for hypothyroidism are similar among patients receiving TBI-based MA and reduced-intensity regimens.
