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1.
HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.
Mahdi, Najat; Al-Ola, Khadija; Al-Subaie, Abeer M; Ali, Muhallab E; Al-Irhayim, Zaid; Al-Irhayim, A Qader; Almawi, Wassim Y.
Clin Vaccine Immunol ; 15(4): 729-31, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18272668

ABSTRACT

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.


Subject(s)
Anemia, Sickle Cell/genetics , Arterial Occlusive Diseases/genetics , Constriction, Pathologic/blood , HLA-DQ Antigens/genetics , HLA-DR Antigens/genetics , Ischemia/blood , Adolescent , Alleles , Anemia, Sickle Cell/blood , Anemia, Sickle Cell/immunology , Arterial Occlusive Diseases/blood , Arterial Occlusive Diseases/immunology , Child , Endothelium, Vascular/pathology , Erythrocytes, Abnormal/pathology , Female , Genetic Predisposition to Disease , HLA-DQ beta-Chains , HLA-DRB1 Chains , Haplotypes , Humans , Male
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