Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon.

Revisiting the classical model by Ross and Kermack-McKendrick, the Susceptible−Infectious−Recovered (SIR) model used to formalize the COVID-19 epidemic, requires improvements which will be the subject of this article. The heterogeneity in the age of the populations concerned leads to considering models in age groups with specific susceptibilities, which makes the prediction problem more difficult. Basically, there are three age groups of interest which are, respectively, 0−19 years, 20−64 years, and >64 years, but in this article, we only consider two (20−64 years and >64 years) age groups because the group 0−19 years is widely seen as being less infected by the virus since this age group had a low infection rate throughout the pandemic era of this study, especially the countries under consideration. In this article, we proposed a new mathematical age-dependent (Susceptible−Infectious−Goneanewsusceptible−Recovered (SIGR)) model for the COVID-19 outbreak and performed some mathematical analyses by showing the positivity, boundedness, stability, existence, and uniqueness of the solution. We performed numerical simulations of the model with parameters from Kuwait, France, and Cameroon. We discuss the role of these different parameters used in the model; namely, vaccination on the epidemic dynamics. We open a new perspective of improving an age-dependent model and its application to observed data and parameters.

Estimation of cumulative incidence functions when the lifetime distributions are uniformly stochastically ordered.

In the competing risks problem an important role is played by the cumulative incidence function (CIF), whose value at time t is the probability of failure by time t from a particular type of risk in the presence of other risks. Assume that the lifetime distributions of two populations are uniformly stochastically ordered. Since this ordering may not hold for the empiricals due to sampling variability, it is natural to estimate these distributions under this constraint. This will in turn affect the estimation of the CIFs. This article considers this estimation problem. We do not assume that the risk sets in the two populations are related, give consistent estimators of all the CIFs and study the weak convergence of the resulting processes. We also report the results of a simulation study that show that our restricted estimators outperform the unrestricted ones in terms of mean square error. A real life example is used to illustrate our theoretical results.