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Limb regeneration in salamanders and digital tip regeneration in experimental mice: implications for the hand surgeon.

Al-Qattan, M M; Al-Qattan, A M; Al-Maged Ahmed, D A; Abd Al-Wahed, M M; Shier, M K.

J Hand Surg Eur Vol ; 39(9): 989-93, 2014 Nov.

Article in English | MEDLINE | ID: mdl-24619249

ABSTRACT

UNLABELLED: Several lessons and observations from limb regeneration in animals could open new insights to direct related research in the field of hand surgery. This article briefly reviews the biology of limb regeneration in salamanders and experimental mice, with special emphasis on implications for hand surgery. LEVEL OF EVIDENCE: 5.

Subject(s)

Animals, Newborn/physiology , Forelimb/physiology , Hindlimb/physiology , Mice/physiology , Regeneration/physiology , Urodela/physiology , Animals , Bone Morphogenetic Protein 4/physiology , Fetal Development/physiology , Finger Injuries/physiopathology , Finger Injuries/surgery , Homeodomain Proteins/physiology , Humans , Limb Buds/drug effects , Limb Buds/physiology , Regeneration/drug effects , Species Specificity , Translational Research, Biomedical , Tretinoin/pharmacology

ABSTRACT

Subject(s)

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