ABSTRACT
Electrospinning's production method has been streamlined and perfected because to advancements in technology and increased demand. While working with electrospun fibers, it is crucial to ensure that they are collected in the correct orientation. Electrospun fibers can be either aligned or random. In contrast to randomly oriented fibers, all aligned ones will point in the same direction. Our results show that a low-cost, tailored electrospinning device can achieve equivalent performance to that of a commercially available system. High voltage (up to 36 kV) and nanofiber orientation adjustments are now being made to the proposed device. A high-voltage direct-current electrical power supply that is custom-built per order and wired by hand. Two specialized collectors, one portable and manufactured from conductive material for random nanofibers, and the other an inexpensive rotational drum collector for aligned nanofibers, have been developed to allow for precise orientation control. By applying Image J software to scanning electron micrographs, we were able to determine the average diameter and orientation of the fibers produced by the electrospinning apparatus, demonstrating its potential to produce nanoscale directed fibers. Because of this research, it's possible that schools will be able to afford an electrospinning system at a price far lower than the current market price.
ABSTRACT
PURPOSE: The daily life management of patients with Alzheimer's disease (AD) constitutes a significant and rapidly expanding health-care responsibility. In this study, an innovative prototype of a wireless-sensing smart wearable medical device (SWMD) is proposed as a multi-functions solution for Alzheimer patients. The SWMD is aimed to assemble three main biomedical engineering advances: 1) use of a Wi-Fi microcontroller, 2) simultaneous monitoring of a set of vital biomarkers, and 3) cautions of fall down conditions, in addition to GPS location indicator. METHODS: The SWMD employs a Wi-Fi controller that is incorporated with electronic circuits to monitor three vital signals (temperature, heart rate, and oxygen saturation), fall down conditions in three directions (X, Y, and Z axis), and GPS location. The SWMD was connected to the Firebase Service (database hosted on the Internet Cloud). The proposed device was tested on 13 normal volunteers. The left side, right side, forward, and backward fall down conditions were assessed. The prototype's functions during daily activity such as rising hand, sitting down or standing up, and walking conditions were also assessed. RESULTS: The three assembled functions were all successfully incorporated to build the SWDM device as a suggested solution offering real-time alerts during daily activity to AD patients. The Bland-Altman statistical test showed no significant difference (p-value >0.05) between the SWMD biomarkers' acquisition and the reference methods. The gyro/accelerator sensor yielded 93% sensitivity in fall down detection and 95% specificity during daily activities. The GPS yielded correct positioning of the SWDM holder, while the internet cloud allowed saving and managing all vital biomarkers daily. CONCLUSION: The SWMD is a possible solution for daily life support for AD patients. It incorporates three functions in one single device, GPS location indicator, monitoring set of biomarkers, and fall down alert, which are all controlled via a Wi-Fi micro controller on-line connected to Internet Cloud. It successfully would allow the management of the daily records as well as the real-time alerts to remote persons.