ABSTRACT
Two new flavonoids, 8-hydroxyisoscoparin (1) and luteolin 7-O-glucoside 4''-sulfate (2), along with eight known flavonoids, including luteolin 7-O-glucoside 2''-sulfate, were isolated and identified from Washingtonia filifera. All compounds were characterized by (1)H-NMR, (13)C-NMR, CI-MS, FABMS and UV. The antioxidant activities of various W. filifera extracts were determined.
Subject(s)
Antioxidants/pharmacology , Arecaceae/chemistry , Flavonoids/pharmacology , Antioxidants/chemistry , Antioxidants/isolation & purification , Flavonoids/chemistry , Flavonoids/isolation & purification , Magnetic Resonance Spectroscopy , Spectrometry, Mass, Fast Atom Bombardment , Spectrophotometry, UltravioletABSTRACT
Effect of aspirin on some biochemical and nutritional parameters was studied in rats fed with high fat, low fat, high protein or low protein diets. Two doses of aspirin (50 and 150 mg/kg rat body weight) were tested. The experiment continued for 10 days. Results showed that, when rats fed high fat diet, high dose of aspirin significantly decreased body weight gain, food efficiency ratio, plasma high density lipoproteins-cholesterol and its ratio to total cholesterol. Low dose of aspirin significantly reduced plasma total lipids. Low aspirin dose significantly increased plasma glucose level, when low fat diet was fed. Feeding high protein diet during administration of both doses of aspirin significantly reduced plasma total lipids and albumin/globulin ratio, while both doses significantly elevated plasma globulins. Low aspirin dose reduced plasma HDL-ch and significantly elevated plasma total proteins. In rats fed low protein diet, both aspirin doses significantly increased plasma triglycerides. The high dose significantly increased albumin/globulin ratio.
Subject(s)
Aspirin/pharmacology , Dietary Fats/administration & dosage , Dietary Proteins/administration & dosage , Animals , Evaluation Studies as Topic , Male , Rats , Rats, Sprague-DawleyABSTRACT
Seven types of diets commonly consumed in Egypt were studied in hyperlipemic rats. Each of the seven diets were fed to a group of hyperlipemic rats. The diets contain white beans and whole wheat bread (Diet 1); cabbage and peas (2); spinach and carrots (3); whole wheat bread and bean sprouts (4); whole wheat bread, white beans and peas (5); white beans and carrots (6) and the last diet contains peas and carrots (7). The experiment continued for 5 weeks, at the end of which different plasma lipids and biological parameters were compared to hyperlipemic rats fed the control diet for 5 weeks. Results showed that plasma total cholesterol of rats of all groups showed significant decrease, except in rats fed diet 6 in which no significant change was noticed. Plasma total lipids of rats fed diet 5 decreased significantly. Plasma phospholipids of rats fed diets 3 and 7 increased significantly. Rats fed diet 3 showed decreased levels of plasma high density lipoprotein-cholesterol. Body weight gain of rats fed diets 1, 2 and 3 decreased significantly. Total food intake was noticed to decrease on feeding diets 1 and 6. Significant decrease was produced in food efficiency ratio of rats fed diets 1, 5 and 6. Feeding any type of the previous seven diets produced significant increase of feces weight.
