ABSTRACT
BACKGROUND: Sepsis is a life-threatening condition that requires aggressive and rapid intervention. However, data on the association between antibiotic administration timing in neonatal sepsis and neonatal outcomes is limited, particularly in the gulf area. OBJECTIVE: This study aimed to evaluate the association between the timing of antibiotic administration and the outcome of neonatal sepsis. DESIGN AND SETTING: This retrospective comparative study was conducted through data collection from medical records of patients with neonatal sepsis. The patients were categorized into two groups based on the time interval between antibiotic prescription and drug administration: non-delayed group consisted of patients who received antibiotics within 3 h and the delayed group consisted of those who received antibiotics after 3 h. RESULTS: A total of 237 neonates diagnosed with sepsis were included, of which 9.3% had necrotizing enterocolitis, 35% had bronchopulmonary dysplasia, and 6.3% had maternal chorioamnionitis. Additionally, 18.6% of the neonates' mothers were prescribed with antibiotics during labor, and 5.5% had maternal fever. Staphylococcus epidermidis was the most commonly isolated strain (24.1%). Of the total neonates, 87.3% received antibiotics within the first 3 h from the prescription. Survival rate was significantly higher and the risk of complications such as necrotizing enterocolitis, and bronchopulmonary dysplasia was significantly lower in the non-delayed group. Moreover, the length of hospital stay was significantly shorter in the non-delayed group. CONCLUSION: Early antibiotic administration in patients with neonatal sepsis can improve the survival rate and reduce the incidence of complications.
Subject(s)
Bronchopulmonary Dysplasia , Enterocolitis, Necrotizing , Neonatal Sepsis , Sepsis , Pregnancy , Female , Humans , Infant, Newborn , Neonatal Sepsis/drug therapy , Neonatal Sepsis/epidemiology , Neonatal Sepsis/diagnosis , Retrospective Studies , Enterocolitis, Necrotizing/drug therapy , Enterocolitis, Necrotizing/epidemiology , Bronchopulmonary Dysplasia/drug therapy , Anti-Bacterial Agents/therapeutic use , Sepsis/drug therapy , Sepsis/epidemiologyABSTRACT
Background: Vaccination is considered to be the ideal way for population immunity, and willingness in taking the COVID-19 vaccine has been a controversial issue worldwide. The commonly reported adverse events of the COVID-19 vaccination have made people question the safety of the vaccine, especially for women with dermal filler and using cosmetics injections. It has been reported that some COVID-19 vaccines can cause side effects in women with dermal filler injections. In this study, we aimed to assess the perception and attitude of females with dermal fillers in Riyadh towards the COVID-19 vaccine using a self-answered questionnaire. Methods: A total of 352 females participated in the study of different ages and nationalities. our study findings indicate that the mean knowledge and attitude scores of females with dermal fillers regarding the COVID-19 vaccine are sub-optimal. Results: Knowledge is significantly related to factors such as educational level, and chronic disease status, while attitude scores are significantly associated with nationality, educational level, COVID-19 vaccination status, previous history of taking the seasonal flu vaccine, and source of information related to COVID-19. Conclusion: These findings suggest the need to increase awareness regarding the COVID-19 vaccine and improve the attitude toward it.