ABSTRACT
The aerial parts of Triumfetta flavescens H. (N. O. Tiliaceae) afforded a new alkaloidal steroid glycoside, characterized as stigma 5(6)-ene-7,22-dione-25-methylamino-3 beta,23 beta-diol-3-O-beta-D- glucoside and designated as triumfettoside (1); and a new sterol identified as stigma 5(6)-ene-7,22-dione-3 beta,23 beta-diol, designated as triumfettosterol (2). Their structures were elucidated on the basis of chemical and spectral analysis.
Subject(s)
Steroids/chemistry , Sterols/chemistry , Triumfetta/chemistry , Chromatography, Thin Layer , Magnetic Resonance Spectroscopy , Saudi Arabia , Spectrophotometry, Infrared , Steroids/isolation & purification , Sterols/isolation & purificationABSTRACT
An ethanol extract of 'Amla' Emblica officinalis Gaertn. was examined for its antisecretory and antiulcer activities employing different experimental models in rats, including pylorus ligation Shay rats, indomethacin, hypothermic restraint stress-induced gastric ulcer and necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl). Oral administration of Amla extract at doses 250 mg/kg and 500 mg/kg significantly inhibited the development of gastric lesions in all test models used. It also caused significant decrease of the pyloric-ligation induced basal gastric secretion, titratable acidity and gastric mucosal injury. Besides, Amla extract offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. Histopathological analyses are in good agreement with pharmacological and biochemical findings. The results indicate that Amla extract possesses antisecretory, antiulcer, and cytoprotective properties.
Subject(s)
Gastric Mucosa/drug effects , Phyllanthus emblica , Plant Extracts/pharmacology , Animals , Anti-Ulcer Agents/pharmacology , Anti-Ulcer Agents/therapeutic use , Disease Models, Animal , Ethanol/administration & dosage , Female , Fruit/chemistry , Gastric Mucosa/metabolism , Gastric Mucosa/pathology , Indomethacin/administration & dosage , Male , Peptic Ulcer/chemically induced , Peptic Ulcer/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Pylorus/surgery , Rats , Rats, Wistar , Sodium Chloride/administration & dosage , Sodium Hydroxide/administration & dosageABSTRACT
Two new alkaloids, haplotubinone (3) and haplotubine (4), were isolated from the aerial parts of Haplophyllum tuberculatum together with the known lignan diphyllin. The structures of the new alkaloids were established by spectroscopic methods in conjunction with X-ray crystallographic analysis of 3. In addition, the amide N-(2-phenylethyl)-benzamide has been identified in this source for the first time.
Subject(s)
Alkaloids/chemistry , Alkaloids/isolation & purification , Plants, Medicinal/chemistry , Benzamides/chemistry , Benzamides/isolation & purification , Biological Factors/chemistry , Biological Factors/isolation & purification , Crystallography, X-Ray , Plant Extracts/chemistry , Saudi ArabiaABSTRACT
A novel beta-hydroxychalcone, galiposin, was isolated from the bark of Galipea granulosa. The structure of galiposin was established via spectroscopic analysis, including high resolution one- and two-dimensional nuclear magnetic resonance spectrometry, as well as mass spectroscopy.
ABSTRACT
A novel chromone, granulosin (1), has been isolated from the bark of Galipea granulosa. The extract of the bark, as well as granulosin (1), exhibited lethality in the brine shrimp test. The structure of granulosin (1) as 2-propyl-7,8-(methylenedioxy)chromone was established via spectroscopic analysis.
