ABSTRACT
Background: End-stage liver disease (ESLD) is not considered a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, lifestyle characteristics commonly associated with increased ASCVD risk are highly prevalent in ESLD. Emerging literature shows a high burden of asymptomatic coronary artery disease (CAD) in patients with ESLD and a high ASCVD risk in liver transplantation (LT) recipients. Coronary artery calcium score (CAC) is a noninvasive test providing reliable CAD risk stratification. We implemented an LT evaluation protocol with CAC playing a central role in triaging and determining the need for further CAD assessment. Here, we inform our results from this early experience. Methods: Patients with ESLD referred for LT evaluation were prospectively studied. We compared accuracy of CAC against that of CAD risk factors/scores, troponin I, dobutamine stress echocardiogram (DSE), and single-photon emission computed tomography (SPECT) to detect coronary stenosis ≥70 (CAD ≥ 70) per left heart catheterization (LHC). Thirty-day post-LT cardiac outcomes were also analyzed. Results: One hundred twenty-four of 148 (84%) patients underwent CAC, 106 (72%) DSE/SPECT, and 50 (34%) LHC. CAC ≥ 400 was found in 35 (28%), 100 to 399 in 17 (14%), and <100 in 72 (58%). LHC identified CAD ≥ 70% in 8 of 29 (28%), 2 of 9 (22%), and 0 of 4, respectively. Two acute coronary syndromes occurred after LT in a patient with CAC 811 (CAD < 70%), and one with CAC 347 (CAD ≥ 70%). No patients with CAC < 100 presented with acute coronary syndrome after LT. When using CAD ≥ 70% as primary endpoint of LT evaluation, CAC ≥ 346 was the only test showing predictive usefulness (negative predictive value 100%). Conclusions: CAC is a promising tool to guide CAD risk stratification and need for LHC during LT evaluation. Patients with a CAC < 100 can safely undergo LT without the need for LHC or cardiac stress testing, whereas a CAC < 346 accurately rules out significant CAD stenosis (≥70%) on LHC, outperforming other CAD risk-stratification strategies.
Subject(s)
Adenocarcinoma/diagnosis , Liposarcoma/pathology , Stomach Neoplasms/diagnosis , Adenocarcinoma/pathology , Cardia/diagnostic imaging , Cardia/pathology , Diagnosis, Differential , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Endosonography , Gastric Fundus/diagnostic imaging , Gastric Fundus/pathology , Gastric Mucosa/diagnostic imaging , Gastric Mucosa/pathology , Gastrointestinal Stromal Tumors/diagnosis , Gastroscopy , Humans , Leiomyoma/diagnosis , Middle Aged , Stomach Neoplasms/pathology , Tomography, X-Ray ComputedSubject(s)
Carcinoma, Verrucous/diagnosis , Esophageal Neoplasms/diagnosis , Aged , Carcinoma, Verrucous/pathology , Carcinoma, Verrucous/surgery , Endosonography , Esophageal Neoplasms/pathology , Esophageal Neoplasms/surgery , Esophagostomy , Esophagus/diagnostic imaging , Esophagus/pathology , Esophagus/surgery , Humans , Male , Tomography, X-Ray ComputedSubject(s)
Carcinoma, Hepatocellular/diagnostic imaging , Carcinoma, Hepatocellular/surgery , Choledochal Cyst/diagnostic imaging , Choledochal Cyst/pathology , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/surgery , Aged , Biopsy , Carcinoma, Hepatocellular/pathology , Cholangiopancreatography, Endoscopic Retrograde , Choledochal Cyst/surgery , Diagnosis, Differential , Endosonography , Humans , Liver Function Tests , Liver Neoplasms/pathology , Male , Stents , Tomography, X-Ray ComputedABSTRACT
Hypermagnesemia is a rare and under-recognized cause of paralytic ileus. We report a case of a 21-year-old primigravida who was managed aggressively for preeclampsia and presented with postpartum paralytic ileus. Detailed history was employed to consider hypermagnesemia-induced ileus as the working diagnosis, and the patient improved with correction of the electrolyte imbalance. Hypermagnesemia-induced lethargy, decreased reflexes, muscle weakness, flaccid paralysis, respiratory muscle paralysis, and cardiac arrest are well-described; however, intestinal smooth muscle dysfunction leading to paralytic ileus has never been reported in the setting of magnesium use for peripartum preeclampsia management.