ABSTRACT
Knee osteoarthritis (KOA) is a chronic disease that impedes movement, especially in the elderly, affecting more than 5% of people worldwide. KOA goes through many stages, from the mild grade that can be treated to the severe grade in which the knee must be replaced. Therefore, early diagnosis of KOA is essential to avoid its development to the advanced stages. X-rays are one of the vital techniques for the early detection of knee infections, which requires highly experienced doctors and radiologists to distinguish Kellgren-Lawrence (KL) grading. Thus, artificial intelligence techniques solve the shortcomings of manual diagnosis. This study developed three methodologies for the X-ray analysis of both the Osteoporosis Initiative (OAI) and Rani Channamma University (RCU) datasets for diagnosing KOA and discrimination between KL grades. In all methodologies, the Principal Component Analysis (PCA) algorithm was applied after the CNN models to delete the unimportant and redundant features and keep the essential features. The first methodology for analyzing x-rays and diagnosing the degree of knee inflammation uses the VGG-19 -FFNN and ResNet-101 -FFNN systems. The second methodology of X-ray analysis and diagnosis of KOA grade by Feed Forward Neural Network (FFNN) is based on the combined features of VGG-19 and ResNet-101 before and after PCA. The third methodology for X-ray analysis and diagnosis of KOA grade by FFNN is based on the fusion features of VGG-19 and handcrafted features, and fusion features of ResNet-101 and handcrafted features. For an OAI dataset with fusion features of VGG-19 and handcrafted features, FFNN obtained an AUC of 99.25%, an accuracy of 99.1%, a sensitivity of 98.81%, a specificity of 100%, and a precision of 98.24%. For the RCU dataset with the fusion features of VGG-19 and the handcrafted features, FFNN obtained an AUC of 99.07%, an accuracy of 98.20%, a sensitivity of 98.16%, a specificity of 99.73%, and a precision of 98.08%.
ABSTRACT
Alzheimer's disease (AD) is considered one of the challenges facing health care in the modern century; until now, there has been no effective treatment to cure it, but there are drugs to slow its progression. Therefore, early detection of Alzheimer's is vital to take needful measures before it develops into brain damage which cannot be treated. Magnetic resonance imaging (MRI) techniques have contributed to the diagnosis and prediction of its progression. MRI images require highly experienced doctors and radiologists, and the analysis of MRI images takes time to analyze each slice. Thus, deep learning techniques play a vital role in analyzing a huge amount of MRI images with high accuracy to detect Alzheimer's and predict its progression. Because of the similarities in the characteristics of the early stages of Alzheimer's, this study aimed to extract the features in several methods and integrate the features extracted from more than one method into the same features matrix. This study contributed to the development of three methodologies, each with two systems, with all systems aimed at achieving satisfactory accuracy for the detection of AD and predicting the stages of its progression. The first methodology is by Feed Forward Neural Network (FFNN) with the features of GoogLeNet and DenseNet-121 models separately. The second methodology is by FFNN network with combined features between GoogLeNet and Dense-121 models before and after high-dimensionality reduction of features using the Principal Component Analysis (PCA) algorithm. The third methodology is by FFNN network with combined features between GoogLeNet and Dense-121 models separately and features extracted by Discrete Wavelet Transform (DWT), Local Binary Pattern (LBP) and Gray Level Co-occurrence Matrix (GLCM) methods called handcrafted features. All systems yielded super results in detecting AD and predicting the stages of its progression. With the combined features of the DenseNet-121 and handcrafted, the FFNN achieved an accuracy of 99.7%, sensitivity of 99.64%, AUC of 99.56%, precision of 99.63%, and a specificity of 99.67%.
