ABSTRACT
Almost all of the deaths happening under the age of 5 occur in the developed countries of Africa and Asia. This study included children admitted to the surgical care, aged 6 months to 5 years, who suffered from acute gastroenteritis and received treatment at Samawah, Iraq, from December 2018 to December 2019. Test results detected different types of rotaviruses, adenoviruses, astroviruses using ELISA. 56.6% of the infections were attributed to a viral pathogen. The main cause was attributed to rotavirus and adenovirus. The causative agents of diarrheal diseases in 28.1% of cases are rotaviruses, in 17.05% - adenoviruses, in 11.43% - astroviruses. Viral mono-infections are detected more often than mixed infections. Viral intestinal infections are characterized by seasonality and rise in the cold season, with a peak incidence of rotavirus infection in April, adenovirus infection in November, and astrovirus infection in December.
Subject(s)
Gastroenteritis , Rotavirus , Child , Child, Hospitalized , Gastroenteritis/epidemiology , Humans , Infant , Iraq/epidemiology , Prevalence , SeasonsABSTRACT
Heavy alcohol drinking alters glucose metabolism, but the inheritability of this effect of alcohol is not well understood. We used an animal model of preconception alcohol exposure in which adult female rats were given free access to 6.7% alcohol in a liquid diet and water for about 4 weeks, went without alcohol for 3 weeks, and then were bred to generate male and female offspring. Control animals were either ad lib-fed rat chow or pair-fed an isocaloric liquid diet during the time of alcohol-feeding in the experimental animals. Our results show that the female rats fed with alcohol in the liquid diet, but not with the isocaloric liquid diet, prior to conception had an altered stress gene network involving glucose metabolism in oocytes when compared with those in ad lib-fed chow diet controls. The offspring born from preconception alcohol-fed mothers showed significant hyperglycemia and hypoinsulinemia when they were adults. These rats also showed increased levels of inflammatory cytokines and cellular apoptosis in the pancreas, altered insulin production and actions in the liver, and a reduced number of proopiomelanocortin neurons in the hypothalamus. Replenishment of proopiomelanocortin neurons in these animals normalized the abnormal glucose to restore homeostasis. These data suggest that preconception alcohol exposures alter glucose homeostasis by inducing proopiomelanocortin neuronal functional abnormalities. Our findings provide a novel insight into the impact of high doses of alcohol on the female gamete that may cause inheritance of an increased susceptibility to diabetes.
Subject(s)
Diabetes Mellitus/chemically induced , Ethanol/pharmacology , Gene Expression Regulation/drug effects , Prenatal Exposure Delayed Effects/metabolism , Animal Feed , Animals , Apoptosis , Blood Glucose , Cytokines/genetics , Cytokines/metabolism , Diet , Female , Gene Regulatory Networks/drug effects , Glucose/metabolism , Insulin/metabolism , Liver/drug effects , Liver/metabolism , Male , Neurons/drug effects , Neurons/metabolism , Pregnancy , Pro-Opiomelanocortin/metabolism , RatsABSTRACT
BACKGROUND AND AIM: Glucagon plays a significant role in glucose homeostasis by controlling hepatic glucose output in terms of both hypoglycemic and normoglycemic conditions. This study aimed to determine the amount and intensity of insulin and glucagon in addition to estimating the relationship between α- and ß-cells for two animals, camel and buffalo. MATERIALS AND METHODS: Twenty fresh pancreas samples were collected from 10 buffalo and 10 camel adults immediately after slaughter from AL-Kut abattoir, Al- Kut, Iraq. Hematoxylin and eosin staining technique and the immunohistochemistry technique were used. RESULTS: The histological results, for both animals, showed the cells of the pancreatic islet could be differentiated from the exocrine cells by their paler appearance. The pancreatic islets were round, oval, and irregular shaped. In the camel, the pancreatic islets had a larger diameter than that in the buffalo. The average diameter of ß-cells and their percentage was higher than those of the α-cells in the camel. In the buffalo, glucagon-immunoreactive cells were found in abundance with high intensity, whereas insulin-immunoreactive cells were more prominent with high intensity in the camel. In both animals, the α-cells and glucagon-immunoreactive cells were distributed on the peripheries of the pancreatic islets, whereas the ß-cells were distributed throughout the pancreatic islets. CONCLUSION: The study inferences that these differences may be due to the differences in the environment of the animals which affect the structures of body organs.
