Quality assurance tests for the Gamma Knife® Icon™ image guidance system.

INTRODUCTION: The Gamma Knife® Icon™ comes with an image guidance system for tracking patient motion and correcting for inter- and intrafractional shifts, mainly used with frameless thermoplastic immobilization. The system consists of a cone-beam CT (CBCT) and a couch-mounted infrared camera (IFMM). We report our quality assurance program for Icon's image guidance system. METHODS: The manufacturer-provided tool is used for daily checks of CBCT positional precision. Catphan® phantom is used for monthly checks of CBCT image qualities (uniformity, contrast to noise ratio (CNR), and spatial resolution) for the two acquisition presets (low-dose and high-quality presets). On a semi-annual schedule, we use a frame tool to check the agreement of CBCT-based and Frame-based stereotactic space coordinates by comparing the locations of five attached ball bearings in CT-sim scans (Frame-based coordinates determination) and in Icon's CBCT scans. On an annual basis, the accuracy of IFMM, image registration, and delivery-after-shift are tested using a translational stage. A weighted CT dose index is measured annually with a pencil chamber in CTDI head phantom. RESULTS: The CBCT precision check: 0.12 ± 0.04 mm (maximum deviations average). CBCT image quality: spatial resolution range: [6,7] lp/cm (low), and [7,8] lp/cm (high); uniformity: 12.82 ± 0.69% (low), and 13.01 ± 0.69% (high); CNR: 1.07 ± 0.08 (low), and 1.69 ± 0.10 (high). Agreement of CBCT-based with Frame-based stereotactic coordinates range: [0.33, 0.66] mm. Accuracy of IFMM: 0.00 ± 0.12 mm (average) with 0.27 mm (max.); image registration: 0.03 ± 0.06 mm (average) with 0.23 mm (max.); and delivery-after-shift: 0.24 ± 0.09 mm (average) with 0.42 mm (max.). CTDIw : 2.3 mGy (low), and 5.7 mGy (high). CONCLUSIONS: The manufacturer-required QA checks together with additional user-defined checks are an important combination for a robust quality assurance program ensuring the safe use of Gamma Knife® Icon™'s image guidance and motion management features.

Evaluation of stability of stereotactic space defined by cone-beam CT for the Leksell Gamma Knife Icon.

The Gamma Knife Icon comes with an integrated cone-beam CT (CBCT) for image-guided stereotactic treatment deliveries. The CBCT can be used for defining the Leksell stereotactic space using imaging without the need for the traditional invasive frame system, and this allows also for frameless thermoplastic mask stereotactic treatments (single or fractionated) with the Gamma Knife unit. In this study, we used an in-house built marker tool to evaluate the stability of the CBCT-based stereotactic space and its agreement with the standard frame-based stereotactic space. We imaged the tool with a CT indicator box using our CT-simulator at the beginning, middle, and end of the study period (6 weeks) for determining the frame-based stereotactic space. The tool was also scanned with the Icon's CBCT on a daily basis throughout the study period, and the CBCT images were used for determining the CBCT-based stereotactic space. The coordinates of each marker were determined in each CT and CBCT scan using the Leksell GammaPlan treatment planning software. The magnitudes of vector difference between the means of each marker in frame-based and CBCT-based stereotactic space ranged from 0.21 to 0.33 mm, indicating good agreement of CBCT-based and frame-based stereotactic space definition. Scanning 4-month later showed good prolonged stability of the CBCT-based stereotactic space definition.

The dose penumbra of a custom-made shield used in hemibody skin electron irradiation.

We report our technique for hemibody skin electron irradiation with a custom-made plywood shield. The technique is similar to our clinical total skin electron irradiation (TSEI), performed with a six-pair dual field (Stanford technique) at an extended source-to-skin distance (SSD) of 377 cm, with the addition of a plywood shield placed at 50 cm from the patient. The shield is made of three layers of stan-dard 5/8'' thick plywood (total thickness of 4.75 cm) that are clamped securely on an adjustable-height stand. Gafchromic EBT3 films were used in assessing the shield's transmission factor and the extent of the dose penumbra region for two different shield-phantom gaps. The shield transmission factor was found to be about 10%. The width of the penumbra (80%-to-20% dose falloff) was measured to be 12 cm for a 50 cm shield-phantom gap, and reduced slightly to 10 cm for a 35 cm shield-phantom gap. In vivo dosimetry of a real case confirmed the expected shielded area dose.

IMRT quality assurance using a second treatment planning system.

We used a second treatment planning system (TPS) for independent verification of the dose calculated by our primary TPS in the context of patient-specific quality assurance (QA) for intensity-modulated radiation therapy (IMRT). QA plans for 24 patients treated with inverse planned dynamic IMRT were generated using the Nomos Corvus TPS. The plans were calculated on a computed tomography scan of our QA phantom that consists of three Solid Water slabs sandwiching radiochromic films, and an ion chamber that is inserted into the center slab of the phantom. For the independent verification, the dose was recalculated using the Varian Eclipse TPS using the multileaf collimator files and beam geometry from the original plan. The data was then compared in terms of absolute dose to the ion chamber volume as well as relative dose on isodoses calculated at the film plane. The calculation results were also compared with measurements performed for each case. When comparing ion chamber doses, the mean ratio was 0.999 (SD 0.010) for Eclipse vs. Corvus, 0.988 (SD 0.020) for the ionization chamber measurements vs. Corvus, and 0.989 (SD 0.017) for the ionization chamber measurements vs. Eclipse. For 2D doses with gamma histogram, the mean value of the percentage of pixels passing the criteria of 3%, 3 mm was 94.4 (SD 5.3) for Eclipse vs. Corvus, 85.1 (SD 10.6) for Corvus vs. film, and 93.7 (SD 4.1) for Eclipse vs. film; and for the criteria of 5%, 3 mm, 98.7 (SD 1.5) for Eclipse vs. Corvus, 93.0 (SD 7.8) for Corvus vs. film, and 98.0 (SD 1.9) for Eclipse vs. film. We feel that the use of the Eclipse TPS as an independent, accurate, robust, and time-efficient method for patient-specific IMRT QA is feasible in clinic.