Pregnancy-Induced Thrombotic Microangiopathy in Systematic Lupus Erythematosus: A Case Report.

Thrombotic microangiopathy (TMA) is a severe systemic disorder with multiorgan manifestations due to thrombosis of the microvasculature. Pregnancy and post-partum are particularly high-risk periods for many forms of TMA. The disease progression is rapid and can lead to organ failure and even death; therefore, urgent recognition and treatment are paramount. The presence of other triggers such as infections or autoimmune diseases like systematic lupus erythematosus (SLE) can add further complexity, which emphasizes the need for definitive diagnostic investigations such as kidney biopsy to promptly direct further diagnosis and management. We describe a case of a 27-year-old female with post-partum severe acute kidney injury and nephrotic range proteinuria. She had a new diagnosis of active SLE and was found to have TMA on kidney biopsy without conclusive features of lupus nephritis. She was managed successfully with plasma exchange with rapid improvement of her kidney markers.

The construction of novel CuO/SnO2@g-C3N4 photocatalyst for efficient degradation of ciprofloxacin, methylene blue and photoinhibition of bacteria through efficient production of reactive oxygen species.

Water pollution due to organic waste and various microorganisms cause severe health problems. Numbers of techniques are used to eliminate organic waste and microorganisms from water because water pollution is a substantial issue in the current era. In the present study, sustainable and effective CuO/SnO2@g-C3N4 nanocomposites were prepared via green and chemical approach. The photo degradation of ciprofloxacin (CIP) and methylene blue (MB) by the green synthesized nanocomposite were tested. Visible and dark conditions both were used to conduct this test. The results showed that the nanocomposite is much more effective in light than in dark conditions. The synthesized nanocomposite was also tested both in light and dark against highly drug resistant microorganisms' Bacillus subtilis (B.subtilis) and Escherichia coli (E.coli). As a result, the antibacterial evaluation revealed substantial antibacterial activity in the presence of light, with a zone of inhibition covering an area of 19 (±0.5) mm and 20 (±0.1) mm, respectively, against gram negative and gram positive bacteria such as E. coli and B. subtilis. The results showed that the CuO/SnO2@g-C3N4 nanocomposite is a stable, eco-friendly photocatalyst with significant resistance to CIP and MB degradation and a substantial inhibitory effect towards microorganisms in visible light.

Scavenging of Organic Pollutant and Fuel Generation through Cost-Effective and Abundantly Accessible Rust: A Theoretical Support with DFT Simulations.

Waste management and energy generation are the foremost concerns due to their direct relationship with biological species and the environment. Herein, we report the utilization of iron rust (inorganic pollutant) as a photocatalyst for the photodegradation of methylene blue (MB) dye (organic pollutant) under visible light (economic) and water oxidation (energy generation). Iron rust was collected from metallic pipes and calcined in the furnace at 700 °C for 3 h to remove the moisture/volatile content. The uncalcined and calcined rust NPs are characterized through scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier-transform infrared (FTIR) analysis, X-ray Diffraction (XRD), and thermogravimetric analysis (TGA). The morphological study illustrated that the shape of uncalcined and calcined iron rust is spongy, porous, and agglomerated. The XRD and DLS particle sizes are in a few hundred nanometers range. The photodegradation (PD) investigation shows that calcined rust NPs are potent for the PD of modeled MB, and the degradation efficiency was about 94% in a very short time of 11 min. The photoelectrochemical (PEC) measurements revealed that calcined rust NPs are more active than uncalcined rust under simulated 1 SUN illumination with the respective photocurrent densities of ~0.40 and ~0.32 mA/cm2. The density functional theory simulations show the chemisorption of dye molecules over the catalyst surface, which evinces the high catalytic activity of the catalyst. These results demonstrate that cheaper and abundantly available rust can be useful for environmental and energy applications.