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1.
Farm. comunitarios (Internet) ; 14(Supl 1): 1, junio 2022. graf
Article in Spanish | IBECS | ID: ibc-209343

ABSTRACT

JUSTIFICACIÓN: la brecha digital hace referencia a la desigualdad que existe entre personas o zonas geográficas en cuanto al acceso a las Tecnologías de la Información y la Comunicación (TIC). Sin este acceso, una parte de la población carece de las llamadas “habilidades digitales”. Para conseguir reducir dicha brecha digital es fundamental analizar la situación actual de desequilibrio, conocer las causas y llevar a cabo medidas para paliarlas.OBJETIVOS:1. Investigar la brecha digital relacionada con la edad y su impacto en la gestión de la salud.2. Dar a conocer el papel de los farmacéuticos comunitarios en la ayuda tecnológica a los pacientes.3. Evidenciar el papel de los farmacéuticos comunitarios en las explicaciones de los tratamientos prescritos a los pacientes.METODOLOGÍA: se desarrollaron encuestas anónimas para los usuarios de las farmacias comunitarias para conocer sus habilidades tecnológicas. El presente estudio fue aprobado por el comité ético con el código CEEI21/260. Los datos fueron analizados estadísticamente.RESULTADOS/DISCUSIÓN: se obtuvieron resultados de 680 encuestas, de las cuales el 36 % fueron mayores de 65 años. El 88 % de los menores de 65 años utilizan internet y el 58 % busca información sobre sus tratamientos. Estos porcentajes disminuyen al 44 % si el motivo de uso es para solicitar una cita médica. El 66 % solicita información sobre su medicación en la farmacia. Entre los mayores de 65 años, el 51 % son usuarios de Internet, pero sólo el 19 % busca información sobre su medicación y el 17 % lo utiliza para solicitar una cita médica. El 99 % acude a la farmacia para solicitar información sobre sus tratamientos. Con estos datos podemos observar el mayor impacto de las tecnologías entre los menores de 65 años, mientras que en la población mayor, su uso es menor, optando por solicitar ayuda de su farmacéutico. (AU)


Subject(s)
Humans , Population Health Management , Digital Divide , Pharmacists , Patients , Surveys and Questionnaires
2.
Farm. comunitarios (Internet) ; 14(Supl 1): 1, junio 2022. graf
Article in Spanish | IBECS | ID: ibc-209344

ABSTRACT

JUSTIFICACIÓN: las enfermedades crónicas sistémicas son causadas por una alteración del sistema inmunitario, siendo en ocasiones incapacitantes para el paciente, derivando en un estado depresivo y pudiendo asociarse con el estado prodrómico del deterioro cognitivo (DC), en el cual, el paciente presenta una serie de incapacidades y olvidos diferentes a los que surgen por la propia edad. En el presente trabajo, tenemos tres grupos a estudio; dolor crónico e inflamación (Artritis Reumatoide, AR), dolor crónico sin inflamación (Fibromialgia, FM) y controles sin dolor ni inflamación.OBJETIVOS: 1.Detectar posible deterioro cognitivo en la población seleccionada.2.Evaluar los factores de riesgo/prevención de DC.3.Estudiar la medicación utilizada como factor de riesgo de DC.4.Analizar el posible vínculo entre depresión y demencia.METODOLOGÍA: este proyecto fue aprobado por el comité ético con el código CEI21/023. Todos los pacientes firmaron el consentimiento informado como establece el RGPD y la Ley Orgánica 3/2018. Los criterios de inclusión fueron: pacientes de artritis reumatoide o fibromialgia mayores de 50 años y controles sanos de edades similares usuarios de farmacia comunitaria.RESULTADOS/DISCUSIÓN: el 21 % de los pacientes dieron positivo en los test de cribado de deterioro cognitivo. Los fármacos más prescritos fueron los antidepresivos y los ansiolíticos, ambos grupos atraviesan la BHE produciendo efectos anticolinérgicos como reacciones adversas. El dolor crónico que sufren puede desencadenar en un estado depresivo (45 % de depresión), lo que potencia aún más los factores de riesgo de DC. La pérdida de relaciones sociales y las alteraciones de sueño, factores de riesgo de DC, se relacionan con el estado depresivo, lo que nos hace sospechar de la depresión y/o su tratamiento farmacológico como estado prodrómico al DC. (AU)


Subject(s)
Humans , Chronic Pain , Cognitive Dysfunction , Depression , Pharmaceutical Preparations , Patients
3.
Farm. comunitarios (Internet) ; 14(Supl 1): 1, junio 2022. graf
Article in Spanish | IBECS | ID: ibc-209346

ABSTRACT

JUSTIFICACIÓN: la edad es el factor de riesgo más importante en el desarrollo de deterioro cognitivo (DC). En España, en municipios de menos de 1000 habitantes, tres de cada diez personas superan los 65 años. Las poblaciones rurales se diferencian de las urbanas por estar más envejecidas debido a la despoblación. Este hecho implica que el envejecimiento de las zonas rurales constituya un problema de primer orden, siendo prioridad a distintos niveles administrativos. La reserva cognitiva (RC) juega un papel fundamental en la prevención de DC. La escasez de población y falta de recursos dificultan el desarrollo de programas y actividades que incrementen la RC.OBJETIVOS: estudiar la prevalencia de deterioro cognitivo y factores de riesgo asociados en una población rural aislada desde la farmacia comunitaria (FC).MATERIAL Y MÉTODOS: estudio observacional-transversal en personas mayores de 50 años no institucionalizadas que viven en una población no superior a 400 habitantes. Se diseñó un cuestionario had-hoc estructurado en tres bloques con las variables a estudiar. 1. Factores sociodemográficos (edad, sexo, estado civil); 2. Tests de cribado de deterioro cognitivo: Memory Impairment Screening (MIS), Short Portable Mental State Questionnaire (SPMSQ) y Fluidez Verbal Semántica (FVS); 3. Estilo de vida: BMI (kg/m2), MEditerranean Diet Adherence Screener, MEDAS-14, International Physical Activity Questionnaire (IPAQ) y Cuestionario de Reserva Cognitiva de Rami (CRC). Mediante entrevista personal en la zona de atención personalizada de la farmacia. Dicho estudio fue aprobado por el comité de ética (CEI21/222). Todos los pacientes firmaron el consentimiento informado. Los resultados fueron analizados estadísticamente.RESULTADOS/DISCUSIÓN: participaron 47 pacientes: edad media 66,62 (DE=11,81), 65,96 % mujeres (31) y 34,04 % hombres (16). Se detectaron 16 pacientes (34 %) en riesgo de deterioro cognitivo. (AU)


Subject(s)
Humans , Cognitive Dysfunction , Cognitive Reserve , Risk Factors , Patients , Spain
4.
Sci Rep ; 10(1): 16704, 2020 10 07.
Article in English | MEDLINE | ID: mdl-33028919

ABSTRACT

The purpose of this study was to estimate the prevalence of high blood pressure (HBP) in adolescents of the Valencian Autonomous Community (VC) in Spain. Besides, its association with other risk factors related to cardiovascular disease (CVD) or arterial hypertension (AHT) in order to increase our knowledge of public health and to provide advice about healthy diets. We conducted a multicentre, observational, cross-sectional, epidemiological study in a sample of 4402 adolescents from 15 schools during the 2015-2016 school year. The participants were aged between 11 and 18 years, and any individuals already diagnosed with AHT were excluded. In addition to the Physical Activity Questionnaire for Adolescents (PAQ-A), Evaluation of the Mediterranean Diet Quality Index (KIDMED), a lifestyle habits survey, the waist-to-height ratio (WtHR), and body mass index (BMI) were calculated for each participant. Informed Consent was obtained from Parents of the adolescents involved in the current study. The study received approval from the University ethics committee and all procedures were conducted in accordance with the tenets of the Declaration of Helsinki. Chi-squared, Student t-tests, and ANOVA statistical analyses showed that 653 (14.8%) adolescents had previously undiagnosed HBP and that was significantly associated with male sex (p < 0.001), age over 15 years (p < 0.05), and height, weight, waist circumference, WtHR, BMI, and skipping breakfast. Based on the data we obtained in this study, the modifiable factors that influence HBP in adolescents were WtHR, BMI, and skipping breakfast.


Subject(s)
Blood Pressure/physiology , Breakfast , Feeding Behavior/physiology , Hypertension/etiology , Waist-Height Ratio , Adolescent , Body Mass Index , Child , Cross-Sectional Studies , Databases, Factual , Female , Humans , Hypertension/physiopathology , Life Style , Male , Risk Factors
5.
Sci Total Environ ; 595: 584-593, 2017 Oct 01.
Article in English | MEDLINE | ID: mdl-28399497

ABSTRACT

Three medium size constructed wetlands (CWs) with a total surface of 90ha are working since 2009 in the Albufera de Valencia Natural Park (Spain). Two of them are fed with eutrophic waters from l'Albufera Lake. Their objectives are both reduce the phytoplankton biomass and increase the biodiversity; consequently, improved water quality is returned to the lake. A "science based governance" of these CWs is ongoing inside the LIFE+12 Albufera Project to demonstrate the environmental benefits of these features. In this paper, results and relationships among hydraulic operation, physicochemical variables and plankton in two different CWs typologies, five free water surface CW (FWSCW) and one horizontal subsurface flow CW (HSSFCW), were analysed showing that CWs were capable of improving the water quality and biodiversity but showing clear differences depending on the CW type. The CWs worked under different hydraulic load rates (HLR) from <0.12 to 54.75myr-1. Inflow water quality was typical from eutrophic waters with mean values of chlorophyll a (Chl a) about 22-90µgChlal-1 and mean total phosphorus (TP) between 0.122 and 0.337mgl-1. The main conclusion is that HSSFCW was much more efficient than FWSCW in the removal of organic matter, suspended solids and nutrients. The biological role of several shallow lagoons located at the end of the CWs has also been evaluated, showing that they contribute to increase the zooplankton biomass, a key factor to control the phytoplankton blooms.

6.
Rev. esp. anestesiol. reanim ; 61(6): 328-331, jun.-jul. 2014.
Article in Spanish | IBECS | ID: ibc-122793

ABSTRACT

Las técnicas de refuerzo vertebral, como la vertebroplastia y la cifoplastia percutáneas, son técnicas mínimamente invasivas empleadas en el tratamiento de las fracturas-aplastamientos vertebrales. Las técnicas anestésicas empleadas durante estos procedimientos son variadas y con diversos resultados. Presentamos una serie de 6 casos, vertebroplastias y cifoplastias, realizados con anestesia subaracnoidea hipobárica metamérica, en los que la estabilidad hemodinámica y la analgesia obtenidas fueron satisfactorias (AU)


Vertebral reinforcement techniques, such as percutaneous vertebroplasty and kyphoplasty, are minimally invasive procedures used in the treatment of fractured or collapsed vertebras. The anaesthetic techniques employed during these procedures are diverse and with variable results. We report 6 cases, vertebroplasty and kyphoplasty using subarachnoid metameric anaesthesia with a hypobaric technique. Haemodynamic stability and analgesia were satisfactory in all of them


Subject(s)
Humans , Subarachnoid Space , Anesthetics/administration & dosage , Vertebroplasty/methods , Kyphoplasty/methods , Spinal Diseases/surgery , Bupivacaine/administration & dosage , Patient Positioning/methods
7.
Rev Esp Anestesiol Reanim ; 61(6): 328-31, 2014.
Article in Spanish | MEDLINE | ID: mdl-23810405

ABSTRACT

Vertebral reinforcement techniques, such as percutaneous vertebroplasty and kyphoplasty, are minimally invasive procedures used in the treatment of fractured or collapsed vertebras. The anaesthetic techniques employed during these procedures are diverse and with variable results. We report 6 cases, vertebroplasty and kyphoplasty using subarachnoid metameric anaesthesia with a hypobaric technique. Haemodynamic stability and analgesia were satisfactory in all of them.


Subject(s)
Anesthesia, Spinal/methods , Anesthetics, Local/administration & dosage , Bupivacaine/administration & dosage , Vertebroplasty , Aged , Aged, 80 and over , Bone Cements , Female , Head-Down Tilt , Humans , Kyphoplasty , Male , Middle Aged , Patient Acceptance of Health Care , Pressure , Prone Position
9.
Cir. mayor ambul ; 16(3): 114-118, jun.-sept. 2011. tab
Article in Spanish | IBECS | ID: ibc-93143

ABSTRACT

Introducción: Tras el alta se necesita mejorar la comunicación entre la unidad de cirugía sin ingreso y el domicilio de los pacientes para ofrecer la misma calidad asistencial y los mismos cuidados que en la cirugía con ingreso. El objetivo principal del presente estudio es validar el impacto clínico, asistencial y de gestión del sistema de m-Salud de control domiciliario telefónico asistido con imágenes de telefonía móvil y pulsioximetría en el periodo postoperatorio tras intervenciones de cirugía ambulatoria. Material y métodos: Este trabajo presenta los resultados de un estudio prospectivo randomizado de un sistema móvil-health para la monitorización postoperatoria de pacientes en los primeros días del postoperatorio en el domicilio. Se seleccionaron de forma aleatoria 310 pacientes intervenidos de cirugía ambulatoria comparables en complejidad quirúrgica. Evaluamos dos grupos: el grupo piloto (llevaba móvil con transmisión de imágenes del postoperatorio)y el grupo control (sin móvil).Resultados: Los resultados muestran que el control telefónico protocolizado por sí mismo (con o sin imágenes de telefonía móvil) es eficiente en términos de calidad de la información recibida así como en la resolución de complicaciones menores domiciliarias. El grupo piloto requirió mayor tiempo de atención que el grupo control. Conclusiones: Aunque no hayamos observado diferencias entre los dos grupos estudiados consideramos que harían falta estudios posteriores para determinar con mayor exactitud el tipo de paciente idóneo para el control mediante la imagen y pulsioximetría (..) (AU)


Introduction: The rationale behind the need to improve the communication between the ambulatory surgery unit and the patients at home after discharge from ambulatory surgery is to offer a healthcare quality at home comparable to hospital care. Nowadays this improvement is needed, taking into account that more complex operations and patients with higher co morbidity are being included in these programs. The main objective of the study is to validate the clinical impact and management system of a domiciliary control m-health device assisted by mobile phone images and pulsioximetry after ambulatory surgery. Material and methods: This paper presents the results of a randomized prospective study of an m-Health system for post-operative monitoring of patients in the early ambulatory surgery home postoperative process. About 310 patients, with surgeries comparable in complexity, were randomly selected and included in either the intervention or the control group. Results: The results shows that the phone control protocol at home in postoperative process is very efficient in terms of the quality of information received and also in the resolution of late minor complications even compared with the most traditional ways of care. The timing of control of intervention group was longer than the control group. Conclusions: Although we have not observed differences between the two groups studied believe that further studies would be needed to determine more precisely the type of patient suitable for mobile image control and pulsioximetry. In this study is considered necessary to explain clearly instructions and household tips by the relevant personnel before discharge. In the other hand the patients they should known the help paths (direct phone number) in case of necessity (..) (AU)


Subject(s)
Humans , Telemedicine , Continuity of Patient Care/organization & administration , Postoperative Complications/prevention & control , Prospective Studies , Cell Phone , Evaluation of the Efficacy-Effectiveness of Interventions
12.
Rev Esp Anestesiol Reanim ; 57(4): 224-35, 2010 Apr.
Article in Spanish | MEDLINE | ID: mdl-20499801

ABSTRACT

Massive bleeding in obstetrics still ranks among the most frequent causes of maternal morbidity and mortality worldwide. The most frequent type is primary postpartum hemorrhage, which is usually the result of an atonic uterus. The clinical priorities are to assure hemodynamic stability and to correct coagulation abnormalities. If pharmacologic treatment cannot achieve these goals, invasive methods such as interventional vascular radiology or artery ligation must be used. Hysterectomy is the last resort when the previous methods fail. For the best prognosis, in terms of preventing death, maintaining maternal fertility and minimizing morbidity, every maternity ward should have a well-defined multidisciplinary protocol that facilitates diagnosis and immediate treatment.


Subject(s)
Postpartum Hemorrhage , Female , Humans , Postpartum Hemorrhage/etiology , Postpartum Hemorrhage/therapy
15.
Rev. esp. anestesiol. reanim ; 57(4): 224-235, abr. 2010. tab
Article in Spanish | IBECS | ID: ibc-79333

ABSTRACT

La hemorragia obstétrica masiva sigue siendo una delas causas más frecuentes de morbi-mortalidad maternaen todo el mundo. La hemorragia postparto primaria esla más frecuente siendo la atonía uterina su etiologíamás común. Es prioritario garantizar la estabilidadhemodinámica de la paciente y corregir las alteracionesde la coagulación. Si el tratamiento farmacológico resultainsuficiente se deben emplear métodos invasivos comola radiología vascular intervensionista o la ligadura delos vasos arteriales. La histerectomía es la última opcióncuando fracasan las medidas anteriores. Para que el pronósticosea favorable, ya no sólo en términos de mortalidadsino en mantener la fertilidad de la madre y minimizarla morbilidad, es fundamental que cada unidadmaternal cuente con un protocolo de actuación bien definidoy multidisciplinar que facilite el diagnóstico y eltratamiento inmediato(AU)


Massive bleeding in obstetrics still ranks among themost frequent causes of maternal morbidity andmortality worldwide. The most frequent type isprimary postpartum hemorrhage, which is usually theresult of an atonic uterus. The clinical priorities are toassure hemodynamic stability and to correctcoagulation abnormalities. If pharmacologictreatment cannot achieve these goals, invasivemethods such as interventional vascular radiology orartery ligation must be used. Hysterectomy is the lastresort when the previous methods fail. For the bestprognosis, in terms of preventing death, maintainingmaternal fertility and minimizing morbidity, everymaternity ward should have a well-definedmultidisciplinary protocol that facilitates diagnosisand immediate treatment(AU)


Subject(s)
Humans , Female , Adult , Hemorrhage/complications , Uterine Inertia/etiology , Hysterectomy , Misoprostol/therapeutic use , Embolization, Therapeutic/methods , Uterine Inertia/therapy , Risk Factors , Hemorrhage/etiology , Postpartum Hemorrhage/etiology , Postpartum Hemorrhage/therapy , Obstetric Labor Complications/diagnosis , Hemorrhage/drug therapy , Uterine Inertia/physiopathology , Indicators of Morbidity and Mortality , Hemodynamics , Hemodynamics/physiology
17.
Ann Vasc Surg ; 24(3): 393-9, 2010 Apr.
Article in English | MEDLINE | ID: mdl-19932952

ABSTRACT

BACKGROUND: Intraoperative monitoring of cerebral ischemia with shunting during carotid endarterectomy (CEA) remains controversial. Our objective was to evaluate the sensitivity and specificity of BIS changes during carotid clamping in relation to shunted patients in awake CEA. METHODS: Eighty CEAs under cervical block were included. There were two patient groups: with clinical signs of cerebral ischemia (shunted patients) and without signs of cerebral ischemia (nonshunted patients). Data were based on bispectral index (BIS) values and neurological monitoring at different surgery time points, with special attention paid during carotid clamping. BIS values were compared between shunted and nonshunted patients. Sensitivity and specificity, along with positive and negative predictive values of a percentage BIS value decrease during carotid clamping from baseline BIS values, were calculated in both patient groups. RESULTS: Shunting was performed in 11 patients with cerebral ischemia at carotid clamping. Mean BIS values were 82.82+/-11.98 in shunted patients and 92.31+/-5.42 in nonshunted patients at carotid clamping (p<0.001). Relative decreased BIS values in relation to basal BIS values were 13.57% in shunted patients and 3.68% in nonshunted patients (p<0.05). The percentage decrease in BIS was 14%, sensitivity was 81.8% (95% CI 49.9-96.8), and specificity was 89.7% (95% CI 79.3-95.4). CONCLUSION: BIS monitoring during carotid clamping is an easy, noninvasive method which correlates with cerebral ischemia in patients undergoing CEA. A decrease>or=14% from the basal BIS value presents a high negative predictive value, and ischemia is unlikely without a decrease. Nonetheless, a decrease may not always indicate cerebral ischemia with a low positive predictive value.


Subject(s)
Brain Ischemia/diagnosis , Carotid Artery Diseases/surgery , Consciousness Monitors , Consciousness , Electroencephalography/instrumentation , Endarterectomy, Carotid/methods , Monitoring, Intraoperative/instrumentation , Wakefulness , Aged , Brain Ischemia/etiology , Carotid Artery Diseases/psychology , Constriction , Endarterectomy, Carotid/adverse effects , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Sensitivity and Specificity , Time Factors
18.
Rev Esp Anestesiol Reanim ; 56(5): 287-91, 2009 May.
Article in Spanish | MEDLINE | ID: mdl-19580131

ABSTRACT

OBJECTIVES: To compare the efficacy and safety of fentanyl and remifentanil in the prevention of hemodynamic responses to direct laryngoscopy and orotracheal intubation, and to compare the effects of these techniques on peripheral blood oxyhemoglobin saturation in normotensive women undergoing scheduled gynecologic surgery. MATERIAL AND METHODS: Prospective clinical trial in ASA 1-2 patients undergoing gynecologic surgery. The patients were randomized to 2 groups: the remifentanil group received a perfusion of 1 microg x kg(-1) x min(-1) until intubation whereas the fentanyl group received a bolus dose of 2 microg x kg(-1). Etomidate (0.3 mg x kg(-1)) and rocuronium bromide (0.6 mg x kg(-1)) were used for anesthetic induction. Seven serial measurements of systolic, diastolic, and mean arterial pressure were recorded in addition to heart rate and peripheral blood oxyhemoglobin saturation at the following times: baseline, denitrogenation, postinduction, and 3 more times at consecutive 2-minute intervals. RESULTS: Fifty-four patients were enrolled. A statistically significant attenuation of the postintubation hemodynamic response was observed in the remifentanil group. The effect was evident on arterial pressure (P=.0001) and heart rate (P=.031) with respect to baseline values. That protective effect was not seen in the fentanyl group. No differences in peripheral blood oxyhemoglobin saturation were observed. CONCLUSIONS: Remifentanil provides greater hemodynamic control than fentanyl at the doses utilized. No adverse effects attributable to these opioids were observed in either group.


Subject(s)
Fentanyl/administration & dosage , Gynecologic Surgical Procedures , Hemodynamics/drug effects , Hypnotics and Sedatives/administration & dosage , Intubation, Intratracheal/adverse effects , Laryngoscopy/adverse effects , Piperidines/administration & dosage , Adult , Androstanols/administration & dosage , Anesthesia, Intravenous , Anesthetics, Intravenous/administration & dosage , Blood Pressure/drug effects , Double-Blind Method , Etomidate/administration & dosage , Female , Fentanyl/therapeutic use , Heart Rate/drug effects , Humans , Hypnotics and Sedatives/therapeutic use , Infusions, Intravenous , Injections, Intravenous , Middle Aged , Neuromuscular Nondepolarizing Agents/administration & dosage , Oxyhemoglobins/analysis , Piperidines/therapeutic use , Remifentanil , Rocuronium
19.
Rev. esp. anestesiol. reanim ; 56(5): 287-291, mayo 2009. graf, tab
Article in Spanish | IBECS | ID: ibc-72621

ABSTRACT

OBJETIVOS: Comparar la eficacia y seguridad del fentanilocon remifentanilo en la prevención de la respuestahemodinámica asociada a la laringoscopia directa eintubación orotraqueal, y su repercusión sobre la saturaciónperiférica de oxígeno en mujeres normotensasprogramadas para cirugía ginecológica.MATERIAL Y MÉTODO: Estudio clínico prospectivo enpacientes ASA I-II sometidas a cirugía ginecológica. Sedistribuyeron de forma aleatoria en dos grupos: grupoR, remifentanilo 1 μg Kg–1 min–1 hasta la intubación ygrupo F, fentanilo 2 μg Kg–1. Para la inducción anestésicautilizamos etomidato (0,3 mg Kg–1) y bromuro derocuronio (0,6 mg Kg–1). Se realizaron siete medicionesseriadas de la presión arterial sistólica, diastólica ymedia, frecuencia cardiaca y saturación periférica deoxígeno durante los periodos: control, desnitrogenación,postinducción, postintubación y posteriormente cada dosminutos tres determinaciones consecutivas.RESULTADOS: Se incluyeron 54 pacientes. El grupo R mostróun efecto estadísticamente significativo de atenuación dela respuesta hemodinámica postintubación tanto en la presiónarterial (p = 0,0001), como en la frecuencia cardiaca(p = 0,031) respecto de su valor basal. Sin embargo, con elgrupo del fentanilo (grupo F), no se observó dicho efecto protector.No se observaron diferencias en la saturación periféricade oxígeno en ambos grupos durante el estudio.CONCLUSIONES: A las dosis utilizadas, el remifentanilocomparativamente con el fentanilo, ofrece mayor controlhemodinámico. No se observaron efectos secundarios enambos grupos atribuibles a los opiáceos(AU)


OBJETIVES: To compare the efficacy and safety offentanyl and remifentanil in the prevention ofhemodynamic responses to direct laryngoscopy andorotracheal intubation, and to compare the effects ofthese techniques on peripheral blood oxyhemoglobinsaturation in normotensive women undergoingscheduled gynecologic surgery.MATERIAL AND METHODS: Prospective clinical trial inASA 1-2 patients undergoing gynecologic surgery. Thepatients were randomized to 2 groups: the remifentanilgroup received a perfusion of 1 μg·kg-1·min-1 untilintubation whereas the fentanyl group received a bolusdose of 2 μg·kg-1. Etomidate (0.3 mg·kg-1) and rocuroniumbromide (0.6 mg·kg-1) were used for anesthetic induction.Seven serial measurements of systolic, diastolic, and meanarterial pressure were recorded in addition to heart rateand peripheral blood oxyhemoglobin saturation at thefollowing times: baseline, denitrogenation, postinduction,and 3 more times at consecutive 2-minute intervals.RESULTS: Fifty-four patients were enrolled. Astatistically significant attenuation of the postintubationhemodynamic response was observed in the remifentanilgroup. The effect was evident on arterial pressure(P=.0001) and heart rate (P=.031) with respect tobaseline values. That protective effect was not seen in thefentanyl group. No differences in peripheral bloodoxyhemoglobin saturation were observed.CONCLUSIONS: Remifentanil provides greaterhemodynamic control than fentanyl at the doses utilized.No adverse effects attributable to these opioids wereobserved in either group(AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Gynecologic Surgical Procedures/methods , Hemodynamics , /administration & dosage , Hypnotics and Sedatives/administration & dosage , Heart Rate , Intubation, Intratracheal/adverse effects , Laryngoscopy/adverse effects , Piperidines/administration & dosage , Androstanols/administration & dosage , Anesthesia, Intravenous , Anesthetics, Intravenous/administration & dosage , Blood Pressure , Double-Blind Method , Etomidate/administration & dosage , Infusions, Intravenous , Injections, Intravenous , Oxyhemoglobins/analysis , Prospective Studies
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