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Sci Rep ; 8(1): 16649, 2018 11 09.
Article in English | MEDLINE | ID: mdl-30413767

ABSTRACT

Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of preventing MI maybe by dietary supplements. The present study was thus designed to ascertain the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle (CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg), groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7th day in groups B-E animals. On the 9th day electrocardiogram (ECG) was recorded, blood samples and tissue biopsies were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1) which were significantly reduced in guinea pig's pretreated with metoprolol or CurNisNp (P < 0.05). The LC50 of CurNisNp was 3258.2 µg/mL. This study demonstrated that the formulated curcumin-nisin based nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic.


Subject(s)
Cardiotonic Agents/pharmacology , Curcumin/pharmacology , Drug Delivery Systems , Myocardial Infarction/prevention & control , Nanoparticles/administration & dosage , Nisin/pharmacology , Polyesters/chemistry , Adrenergic beta-Agonists/toxicity , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Cardiotonic Agents/administration & dosage , Cardiotonic Agents/chemistry , Curcumin/administration & dosage , Curcumin/chemistry , Drug Therapy, Combination , Guinea Pigs , Isoproterenol/toxicity , Male , Myocardial Infarction/chemically induced , Myocardial Infarction/pathology , Nanoparticles/chemistry , Nisin/administration & dosage , Nisin/chemistry
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