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1.
J Med Case Rep ; 9: 229, 2015 Oct 04.
Article in English | MEDLINE | ID: mdl-26438353

ABSTRACT

INTRODUCTION: Klippel-Feil syndrome is characterized by a congenital fusion of cervical vertebrae. Intracranial teratomas are nongerminomatous germ cell tumors and they account for 0.3 to 0.9% of all intracranial tumors. Teratomas with malignant transformation refer to lesions which give rise to malignant cancer of somatic type. The association between tumors of dermoid origin and Klippel-Feil malformation is extremely rare. Only 23 other cases have so far been reported, and only one case of dermoid tumor with areas of dedifferentiation on squamous cell carcinoma has been described. CASE PRESENTATION: We report the case of a 72-year-old white man with a 2-year history of gait and balance disturbances. A brain magnetic resonance imaging revealed a fourth ventricle neoplastic process with infiltrative features. He was operated through a suboccipital craniectomy with a C1 laminotomy and bilateral vertebral artery transposition. At 6-months follow-up, magnetic resonance imaging showed an early regrowth of the fourth ventricle tumor, with the same radiological features. CONCLUSIONS: Patients with Klippel-Feil malformation could develop posterior fossa dermoid tumors. The malignant potential of such tumors must be considered and surgery is recommended. Particular attention must be focused on the histopathological analysis in order to identify possible foci of malignant transformation.


Subject(s)
Cervical Vertebrae/pathology , Cranial Fossa, Posterior/pathology , Klippel-Feil Syndrome/diagnosis , Teratoma/diagnosis , Aged , Cervical Vertebrae/abnormalities , Cervical Vertebrae/diagnostic imaging , Cranial Fossa, Posterior/abnormalities , Cranial Fossa, Posterior/diagnostic imaging , Cranial Fossa, Posterior/surgery , Dermoid Cyst/pathology , Gait Apraxia/etiology , Humans , Klippel-Feil Syndrome/complications , Klippel-Feil Syndrome/diagnostic imaging , Klippel-Feil Syndrome/pathology , Magnetic Resonance Imaging , Male , Teratoma/diagnostic imaging , Teratoma/pathology , Teratoma/surgery , Tomography, X-Ray Computed , Treatment Outcome
2.
J Biol Regul Homeost Agents ; 29(2): 493-500, 2015.
Article in English | MEDLINE | ID: mdl-26122242

ABSTRACT

It is already known that the conditions of increased oxidative stress are associated to a greater susceptibility to vascular malformations including cerebral cavernous malformations (CCMs). These are vascular lesions of the CNS characterized by abnormally enlarged capillary cavities that can occur sporadically or as a familial autosomal dominant condition with incomplete penetrance and variable clinical expression attributable to mutations in three different genes: CCM1(Krit1), CCM2 (MGC4607) and CCM3 (PDCD10). Polymorphisms in the genes encoding for enzymes involved in the antioxidant systems such as glyoxalase I (GLO I) and paraoxonase I (PON I) could influence individual susceptibility to the vascular malformations. A single nucleotide polymorphism was identified in the exon 4 of GLO 1 gene that causes an amino acid substitution of Ala for Glu (Ala111Glu). Two common polymorphisms have been described in the coding region of PON1, which lead to glutamine → arginine substitution at 192 (Q192R) and a leucine → methionine substitution at 55 (L55M). The polymorphisms were characterized in 59 patients without mutations in the CCM genes versus 213 healthy controls by PCR/RFLP methods using DNA from lymphocytes. We found that the frequency of patients carrying the GLO1 A/E genotype among the case group (56%) was four-fold higher than among the controls (14.1%). In the cohort of CCM patients, an increase in the frequency of PON192 Q/R genotype was observed (39% in the CCM group versus 3.7% in the healthy controls). Similarly, an increase was observed in the proportion of individuals with the genotype R/R in the disease group (5%) in respect to the normal healthy cohort (0.5%). Finally, the frequency of the PON55 heterozygotes L/M genotype was 29% in patients with CCMs and 4% in the healthy controls. The same trend was observed in PON55 homozygous M/M genotype frequency (CCMs 20% vs controls 10%). The present study aimed to investigate the possible association of GLO1 A111E, PON1 Q192R and L55M polymorphisms with the risk of CCMs. We found that individuals with the GLO1 A /E genotype, PON192/QR-RR genotypes and PON55/LM-MM genotypes had a significantly higher risk of CCMs compared with the other genotypes. However, because CCM is a heterogeneous disease, other additional factors might be involved in the initiation and progression of CCM disease.


Subject(s)
Hemangioma, Cavernous, Central Nervous System/genetics , Lactoylglutathione Lyase/genetics , Polymorphism, Single Nucleotide , Adult , Age of Onset , Aged , Amino Acid Substitution , DNA Mutational Analysis , Female , Gene Frequency , Genotype , Haplotypes/genetics , Hemangioma, Cavernous, Central Nervous System/epidemiology , Humans , Italy/epidemiology , Lymphocytes/chemistry , Male , Middle Aged , Pilot Projects , Young Adult
3.
AJNR Am J Neuroradiol ; 36(10): 1853-8, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26113071

ABSTRACT

BACKGROUND AND PURPOSE: MR imaging tractography is increasingly used to perform noninvasive presurgical planning for brain gliomas. Recently, constrained spherical deconvolution tractography was shown to overcome several limitations of commonly used DTI tractography. The purpose of our study was to evaluate WM tract alterations of both the corticospinal tract and arcuate fasciculus in patients with high-grade gliomas, through qualitative and quantitative analysis of probabilistic constrained spherical deconvolution tractography, to perform reliable presurgical planning. MATERIALS AND METHODS: Twenty patients with frontoparietal high-grade gliomas were recruited and evaluated by using a 3T MR imaging scanner with both morphologic and diffusion sequences (60 diffusion directions). We performed probabilistic constrained spherical deconvolution tractography and tract quantification following diffusion tensor parameters: fractional anisotropy; mean diffusivity; linear, planar, and spherical coefficients. RESULTS: In all patients, we obtained tractographic reconstructions of the medial and lateral portions of the corticospinal tract and arcuate fasciculus, both on the glioma-affected and nonaffected sides of the brain. The affected lateral corticospinal tract and the arcuate fasciculus showed decreased fractional anisotropy (z = 2.51, n = 20, P = .006; z = 2.52, n = 20, P = .006) and linear coefficient (z = 2.51, n = 20, P = .006; z = 2.52, n = 20, P = .006) along with increased spherical coefficient (z = -2.51, n = 20, P = .006; z = -2.52, n = 20, P = .006). Mean diffusivity values were increased only in the lateral corticospinal tract (z = -2.53, n = 20, P = .006). CONCLUSIONS: In this study, we demonstrated that probabilistic constrained spherical deconvolution can provide essential qualitative and quantitative information in presurgical planning, which was not otherwise achievable with DTI. These findings can have important implications for the surgical approach and postoperative outcome in patients with glioma.


Subject(s)
Brain Neoplasms/diagnosis , Brain Neoplasms/pathology , Diffusion Tensor Imaging/methods , Glioma/diagnosis , Glioma/pathology , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Neural Pathways/pathology , Pyramidal Tracts/pathology , Adult , Aged , Brain/pathology , Female , Humans , Male , Middle Aged , Neoplasm Grading
4.
Clin Neuroradiol ; 24(1): 29-36, 2014 Mar.
Article in English | MEDLINE | ID: mdl-23525407

ABSTRACT

PURPOSE: Several authors have demonstrated that preoperative embolization of meningiomas reduces blood loss during surgery. However, preoperative embolization is still under debate. Aim of this study is the retrospective evaluation of necrosis score, surgical time, and transfused blood volume, on patients affected by intracranial meningiomas treated with preoperative embolization before surgery, compared with a control group treated only with surgery. METHOD: Twenty-eight patients with meningiomas were subjected to a preoperative embolization with polyvinyl alcohol (PVA). These patients were divided into two groups: group 1, patients with preoperative embolization performed at least 7 days before surgery; and group 2, patients with preoperative embolization performed less than 7 days before surgery. A statistical evaluation was made by comparing necrosis score, surgical time, and transfused blood volume of these groups. Then, we compared these parameters also with group 3, which included patients with surgically treated meningioma who did not undergo preoperative embolization. RESULTS: Surgery time and transfused blood volume were significantly lower in patients who had been embolized at least 7 days before definitive surgery. Furthermore, large confluent areas of necrosis were significantly more frequent in patients with a larger time span between embolization and surgery. CONCLUSION: Preoperative embolization with PVA in patients with intracranial meningiomas is safe and effective, as it reduces the volume of transfused blood during surgical operation. However, patients should undergo surgery at least 7 days after embolization, as a shorter time interval has been correlated with a longer surgical time and a higher transfused blood volume.


Subject(s)
Blood Transfusion , Embolization, Therapeutic/methods , Meningeal Neoplasms/therapy , Meningioma/therapy , Neurosurgical Procedures/methods , Operative Time , Polyvinyl Alcohol/therapeutic use , Blood Volume Determination , Combined Modality Therapy , Female , Hemostatics/therapeutic use , Humans , Male , Meningeal Neoplasms/diagnosis , Meningioma/diagnosis , Middle Aged , Necrosis/diagnosis , Necrosis/prevention & control , Preoperative Care/methods , Radiographic Image Interpretation, Computer-Assisted/methods , Radiography, Interventional/methods , Retrospective Studies , Severity of Illness Index , Treatment Outcome
5.
Neuroradiol J ; 26(3): 277-83, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23859282

ABSTRACT

The cognitive dysmetria theory suggests a disconnectivity between the dorsolateral prefrontal cortex, thalami and vermis to explain the pathophysiology of schizophrenia. This study investigated the metabolic integrity of this neurologic circuit in patients with schizophrenia using proton magnetic resonance spectroscopy (H-MRS). Twenty-two patients with schizophrenia and twelve control subjects were studied. Metabolites concentrations were evaluated by a single-voxel technique in the prefrontal cortex, thalami and vermis. To our knowledge, this is the first H-MRS experience with concomitant evaluation of these regions in schizophrenic patients. We found no significant statistical difference in N-AA, Cho and Cr absolute concentrations and N-AA/Cho, N-AA/Cr and Cho/Cr ratios between the schizophrenic patients and control group. At the vermis, we found a constant spectrum with low levels of N-AA and higher levels of Cho and Cr. Our experience does not clearly support or refute the cognitive dysmetria theory. The consistency of metabolic findings in the cerebellar vermis could represent an important datum, highlighting the specificity of metabolic and functional activity in this region.


Subject(s)
Cerebellum/metabolism , Magnetic Resonance Spectroscopy , Prefrontal Cortex/metabolism , Schizophrenia/pathology , Thalamus/metabolism , Adult , Analysis of Variance , Aspartic Acid/metabolism , Cerebellum/pathology , Choline/metabolism , Creatine/metabolism , Female , Humans , Magnetic Resonance Imaging , Male , Prefrontal Cortex/pathology , Protons , Psychiatric Status Rating Scales , Schizophrenia/metabolism , Thalamus/pathology
6.
Pituitary ; 15 Suppl 1: S57-60, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22222543

ABSTRACT

In prolactin-secreting giant adenomas, cabergoline treatment is the first line approach. Surgery and/or radiotherapy are indicated when the tumour is resistant to medical treatment and continues growing, causing visual field impairment. Data concerning other therapeutic approach are scanty. Although PRL-secreting tumours may express somatostatin receptors type 2, 3 and 5, somatostatin analogs treatment is generally ineffective and peptide receptor radionuclide therapy (PRRT) has never been reported. A 58 year-old woman complaining of severe neurological symptoms caused by a giant prolactinoma, relapsing after surgery and not-responding to dopamine-agonists and octreotide LAR treatment, underwent four cycles of PRRT with 111-Indium-DTPA-octreotide with remarkable tumour shrinkage and a significant improvement in clinical conditions. No side effects were reported. This is the first report on the effectiveness and safety of PRRT with radio-labelled somatostatin analogs in a patient with aggressive giant prolactinoma resistant to conventional treatment.


Subject(s)
Octreotide/analogs & derivatives , Prolactinoma/diagnostic imaging , Prolactinoma/drug therapy , Female , Humans , Middle Aged , Octreotide/therapeutic use , Radionuclide Imaging
8.
J Neurooncol ; 105(2): 225-32, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21512824

ABSTRACT

Osteoblastic meningioma is a rare variant of meningioma characterized by the presence of a variable number of bone spicules within the tumor parenchyma. Its histogenesis has not been yet fully clarified. Herein we report clinical and histological findings and expression of bone matrix proteins (osteocalcin and ostepontin) observed in seven osteoblastic meningiomas. None of the cases displayed recurrences or significant re-growth after partial resection. In 5/7 cases the osseous component occurred in association with psammoma bodies and dystrophic calcification. Interestingly, foci composed of immature bone trabeculae, mineralized chondroid matrix, and osteoclasts were found in one of the two cases with no psammoma bodies or calcification, suggesting enchondral ossification. Positive staining for osteocalcin, which is a marker of terminal osteoblastic differentiation, was observed within the bone spicules in all meningiomas, but not in the chondroid mineralized matrix. On the other hand, immuno-expression of osteopontin, an early osteogenic marker, was observed in the osteoclasts and in mature and immature bone spiculae, calcification, and psammoma bodies. Even more, osteopontin was extensively expressed by the neoplastic cells of cases without calcification or psammoma bodies, suggesting acquisition of osteoblastic phenotype in these meningiomas. In conclusion, osteoblastic meningioma seems to be an indolent variant of meningiomas characterized by a slow growth and good prognosis. Our histological and immunohistochemical findings suggest that bone formation may occur through two different pathways, i.e., as the final step of calcification or through a metaplastic mechanism in cases with absent calcification or psammoma bodies.


Subject(s)
Meningeal Neoplasms/metabolism , Meningeal Neoplasms/pathology , Meningioma/metabolism , Meningioma/pathology , Osteoblasts/pathology , Osteocalcin/metabolism , Osteopontin/metabolism , Adult , Aged , Calcinosis , Female , Humans , Immunoenzyme Techniques , Male , Middle Aged , Osteoblasts/metabolism , Prognosis
9.
Neuroradiol J ; 24(6): 867-71, 2011 Dec 30.
Article in English | MEDLINE | ID: mdl-24059888

ABSTRACT

Non-traumatic intradiploic arachnoid cyst is a rare condition. We describe a young man with typical trigeminal neuralgia and intradiploic arachnoid cyst at the greater wing of the sphenoid. The patient was successfully treated with medical therapy. To our knowledge, this is the first case report of a possible correlation between trigeminal neuralgia and intraosseous arachnoid cyst. We describe the clinical case, the possible pathogenetic mechanism and briefly review the literature.

10.
Neuroradiol J ; 23(4): 473-8, 2010 Sep.
Article in English | MEDLINE | ID: mdl-24148642

ABSTRACT

Cerebral arteriovenous malformations (AVMs) represent congenital anomalies of blood vessels composed of a nidus of anomalous arterial and venous vessels without a capillary network. We describe a case of bleeding cerebral AVM in a pregnant women at the second quarter of gestation and diagnosed by digital subtraction angiography showing a large principal arterial nidus supply. The AVM was treated by endovascular embolization at the 27th week of gestation. The post-operative course was uneventful and a caesarean section was performed at the 37th week of gestation. The endovascular approach may represent a safe method in the treatment of this cerebral condition during pregnancy.

11.
Oncol Rep ; 20(3): 485-92, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18695896

ABSTRACT

Somatostatin anti-proliferative and anti-angiogenic activities, together with the expression of somatostatin receptors (sstrs), account for the use of somatostatin analogues in the treatment of human tumours. In the present study, sstr2A immunohistochemical expression was analyzed in grade II and III meningiomas and was compared with that revealed in grade I meningiomas. Thirty-five formalin-fixed paraffin-embedded meningiomas, comprising 13 grade I, 19 grade II and 3 grade III tumours, according to the WHO 2007 classification, were submitted to immunohistochemical assays for sstr2A. Moreover, in the same cohort of tumours, the immunoexpression of CD105, a specific marker for neo-angiogenesis, as well as the Ki-67 labelling index (LI), reflecting the proliferative activity of the meningiomas, were recorded. Sstr2A immunoreaction was evidenced in 26/35 cases and was localized at the cytoplasm and the plasma membrane in 12 and in 14 cases, respectively. Specifically, a positive staining was found in 7/13 grade I, in 16/19 grade II and in 3/3 grade III tumours, thus demonstrating that sstr2A is frequently expressed in high grade meningiomas. A significantly higher microvessel density (MVD), assessed by CD105 immunostaining and Ki-67 LI were evidenced in high grade meningiomas. A significant correlation was recorded between sstr2A expression and a high MVD of the meningiomas. The existence of a correlation between sstr2A expression and the entity of neo-angiogenesis provides the basis for the use of somatostatin analogue-based therapies in the treatment of meningiomas.


Subject(s)
Biomarkers, Tumor/metabolism , Cell Proliferation , Meningeal Neoplasms/blood supply , Meningeal Neoplasms/metabolism , Meningioma/metabolism , Neovascularization, Pathologic/pathology , Receptors, Somatostatin/metabolism , Adult , Aged , Aged, 80 and over , Antigens, CD/metabolism , Endoglin , Female , Humans , Immunoenzyme Techniques , Ki-67 Antigen/metabolism , Male , Meningeal Neoplasms/pathology , Meningioma/blood supply , Meningioma/pathology , Middle Aged , Neoplasm Staging , Prognosis , Receptors, Cell Surface/metabolism
12.
J Neurosurg Sci ; 52(3): 75-8, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18636051

ABSTRACT

The authors describe the surgical method and results of nonexpansive one-piece multivel laminoplasty of the whole lumbar spine, for microsurgical resection of extensive spinal tumors. This technique allows a very comfortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the spinal anatomy. A nonexpansive whole lumbar one-piece laminoplasty was performed for resection of extensive multilevel lumbar tumors. The authors report an illustrative case of a patient who initially presented with a three-year history of numbness on both legs and progressive difficulty in walking. Two months before admission, he complained of bilateral sciatica and rectourinary dysfunction. A spinal magnetic resonance imaging (MRI) documented an intradural tumor extending from L2 to S1. The patient underwent a nonexpansive whole lumbar one-piece laminoplasty and microsurgical removal of the intradural lesion. The postoperative course was uneventful, the sensory disturbances and bilateral sciatica early recovered while rectourinary disturbance gradually improved up to a complete resolution at one year follow-up. The authors believe that multilevel laminoplasty rather than laminectomy is the technique of choice as a posterior procedure for extensive lumbar spinal tumors. With this technique, it is possible to obtain a very confortable approach to the dura and intradural content, as well as a perfect replacement of the posterior spinal arch with supporting elements and an optimal reconstruction of the normal spine. Moreover, this method prevents postoperative instability and deformity and avoids the so called post-laminectomy epidural membrane.


Subject(s)
Ependymoma/surgery , Laminectomy/methods , Lumbar Vertebrae/surgery , Plastic Surgery Procedures/methods , Spinal Cord Neoplasms/surgery , Dura Mater/anatomy & histology , Dura Mater/surgery , Ependymoma/pathology , Humans , Lumbar Vertebrae/anatomy & histology , Magnetic Resonance Imaging , Male , Postoperative Complications/prevention & control , Spinal Canal/anatomy & histology , Spinal Canal/surgery , Spinal Cord/pathology , Spinal Cord/surgery , Spinal Cord Neoplasms/pathology , Subarachnoid Space/anatomy & histology , Subarachnoid Space/surgery , Treatment Outcome , Young Adult
13.
Childs Nerv Syst ; 22(10): 1263-7, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16648939

ABSTRACT

OBJECTS: Microsurgical resection, stereotactic aspiration and VP shunt have for years been the choice options for the treatment of colloid cysts of the third ventricle. Recently, endoscopic approaches have aroused increasing interest and gained acceptance. Although safer, this minimally invasive approach is considered less efficacious than microsurgery. Relatively long-term results are now available and some conclusions might be inferred on the usefulness of this procedure. MATERIALS AND METHODS: Between 1994 and 2005, 61 patients harbouring a colloid cyst of the third ventricle were treated with neuroendoscopic technique in 11 Italian neurosurgical centres. Cyst diameters ranged from 6 to 32 mm. A flexible endoscope was used in 34 cases, a rigid one in 21, both instruments in six. The technique consisted in cyst fenestrations, colloid aspiration, coagulation of the internal cyst wall and, occasionally, capsule excision. Mean postoperative hospital stay was 6.7 days. Early postoperative neuroimaging revealed a cyst residue in 36 cases (mean diameter 4.3 mm). There were two complications (3.2%). Follow-up varied between 1 and 132 months (mean 32 months, more than 5 years in 17 patients). There were seven asymptomatic recurrences, three of them evolving from a previous residue. CONCLUSION: The endoscopic approach to the treatment of colloid cysts is safe, effective and well accepted by patients. Although asymptomatic, recurrences (11.4%) cast a persisting shadow on the long-term results, and, therefore, the controversy with the traditional microsurgical treatment remains open.


Subject(s)
Brain Diseases/surgery , Cooperative Behavior , Cysts/surgery , Neuroendoscopy/methods , Ventriculostomy/methods , Adolescent , Adult , Aged , Brain Diseases/pathology , Cerebral Ventricles/surgery , Cerebral Ventriculography , Child , Cysts/pathology , Female , Humans , Italy/epidemiology , Magnetic Resonance Imaging/methods , Male , Middle Aged , Neurosurgical Procedures/methods , Stereotaxic Techniques , Tomography, X-Ray Computed/methods
14.
J Viral Hepat ; 10(2): 95-102, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12614465

ABSTRACT

The tissue tropism and possible correlation with liver disease of the TT virus (TTV) as well as its prevalence and genotype distribution remain undefined. TTV-DNA was investigated in paired sera and tissue samples from 144 patients, and sera and cerebrospinal fluids (CSF) from additional six subjects. Of the 144 tissue samples, 128 were liver biopsy specimens from subjects with hepatic disease while 16 were surgically obtained nonliver specimens from patients with extrahepatic disease. TTV cloning, sequencing and genotype analyses were performed on isolates from sera, tissue specimens and peripheral blood mononuclear cells of two patients with hepatic and four patients with extrahepatic pathologies, as well as from sera and CSFs of two subjects. TTV was found in 100% of the examined tissues and in 60.1 and 50% of sera from patients with hepatic and extrahepatic pathologies, respectively. Moreover, TTV was detected in four of the six CSFs analysed but only in two correspondent sera. Genotyping revealed the coexistence of multiple TTV genotypes and genetic variants in each infected individual, and the analysis of TTV mRNA showed the presence of transcripts in all the six different tissues studied. These results indicate that the entire adult population in our area is more likely infected by TTV, although several subjects are not viraemic and that TTV infects many different human tissues and is able to invade the central nervous system.


Subject(s)
DNA Virus Infections/virology , DNA, Viral/metabolism , Torque teno virus/physiology , Adult , Aged , Base Sequence , DNA Virus Infections/blood , DNA Virus Infections/cerebrospinal fluid , DNA, Viral/blood , DNA, Viral/cerebrospinal fluid , Female , Hepacivirus/growth & development , Hepatitis B virus/growth & development , Hepatitis B, Chronic/virology , Hepatitis C, Chronic/virology , Humans , Italy , Male , Middle Aged , Molecular Sequence Data , Phylogeny , Polymerase Chain Reaction , Sequence Alignment , Torque teno virus/genetics , Torque teno virus/growth & development
15.
J Neurosurg Sci ; 46(2): 93-5; discussion 95, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12232557

ABSTRACT

Among unusual abnormalities of the lumbar spine reported since the introduction of Computed Tomography (CT), the presence of gas lucency in the spinal canal, known as vacuum phenomenon, is often demonstrated. On the contrary, epidural gas pseudocyst compressing a nerve root in patients with a lateral disc herniation has rarely been reported. We report a case of a 44-year-old man who experienced violent low back pain and monolateral sciatica, exacerbated by orthostatic position, one week before admission. A lumbosacral spine CT showed the presence of vacuum phenomenon associated with a degenerated disc material and a capsulated epidural gas collection with evidence of root compression. A microsurgical interlaminar approach was carried out and, before the posterior longitudinal ligament was entered, a spherical "bubble" compressing the nerve roots was observed. The capsulated pseudocyst was dissected out, peeled off and excised en bloc. A large part of the posterior longitudinal ligament and the lateral disc herniation were removed. Postoperatively the patient was completely free of symptoms. The mechanism of exacerbation of pain was probably due to the increased radicular compression in the upright posture and, besides the presence of a lateral disc herniation, could be related to a pneumatic squeezing of gas from the intervertebral space into the well capsulated sac by the solicitated L4-L5 motion segment. Histological study of the wall of the pseudocyst showed the presence of fibrous tissue identical to the ligament. We conclude that, in case of a lumbar disc herniation, it is recommended to perform a complete microdiscectomy and an accurate removal of the involved portion of posterior longitudinal ligament in order to prevent pseudocystic formations.


Subject(s)
Cysts/complications , Gases , Longitudinal Ligaments/pathology , Nerve Compression Syndromes/etiology , Adult , Back Pain/etiology , Epidural Space , Humans , Intervertebral Disc Displacement/diagnostic imaging , Intervertebral Disc Displacement/surgery , Lumbar Vertebrae , Male , Nerve Compression Syndromes/diagnostic imaging , Tomography, X-Ray Computed
16.
Minim Invasive Neurosurg ; 45(2): 105-8, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12087509

ABSTRACT

OBJECTIVES: We describe three patients with symptomatic septum pellucidum cysts treated by endoscopic fenestration and discuss the different endoscopic approaches to these cysts. CLINICAL PRESENTATION: The patients are an 8-year-old boy, a 7-year-old boy and a 21-year-old woman; this last also had a right frontal cavernous angioma and a pituitary microadenoma. All patients presented with headache, associated with vomiting in two and behavioral changes in one. In all cases magnetic resonance showed a septum pellucidum cyst. INTERVENTION: Two patients were operated upon by posterior approach through a right occipital burr hole and underwent fenestration from the right occipital horn to the cyst, with a second fenestration from the cyst to the left lateral ventricle in one. Another patient underwent microsurgical removal of a right frontal cavernoma and endoscopic cyst fenestration with both lateral ventricles through a right frontal craniotomy. Postoperatively, headache and vomiting resolved in all cases and behaviour changes improved in one. CONCLUSIONS: Endoscopic fenestration is the treatment of choice for septum pellucidum cysts, where it results in immediate relief of the mass effect of the cyst and in the remission of the associated symptoms. We suggest a posterior approach through a right occipital burr hole. It allows one to easily cannulate the occipital horn, which is usually larger than the frontal one, thus avoiding the risk of damaging the vascular and neural structures surrounding the foramen of Monro. Besides, the endoscopic trajectory is in our opinion more direct. The two-window technique, with fenestration of the cyst into both lateral ventricles, improves the chances of long-term patency.


Subject(s)
Cerebral Ventricle Neoplasms/surgery , Craniotomy/methods , Cysts/surgery , Endoscopy/methods , Septum Pellucidum/surgery , Adenoma/complications , Adenoma/diagnosis , Adenoma/surgery , Adult , Brain Neoplasms/complications , Brain Neoplasms/diagnosis , Brain Neoplasms/surgery , Cerebral Ventricle Neoplasms/complications , Cerebral Ventricle Neoplasms/diagnosis , Child , Cysts/complications , Cysts/diagnosis , Female , Hemangioma, Cavernous, Central Nervous System/complications , Hemangioma, Cavernous, Central Nervous System/diagnosis , Hemangioma, Cavernous, Central Nervous System/surgery , Humans , Magnetic Resonance Imaging , Male , Pituitary Neoplasms/complications , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/surgery , Treatment Outcome
17.
J Neurosurg Sci ; 45(2): 110-3, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11533536

ABSTRACT

A 16-year-old girl complained of 2-year history of right facial pain, episodic vertigo and progressive hearing loss in the right ear. The facial pain was described as an episodic lancinating event confined to the second and third branch of the right trigeminal nerve. Computed tomography and magnetic resonance imaging revealed a 2 cm lesion in the right cerebellopontine-angle. At surgery, a soft, yellowish mass was found incorporating the 7th and 8th cranial nerves. The anterior-inferior cerebellar artery (AICA) was displaced medially and pushed into the sensory portion of the trigeminal nerve root, causing vascular compression. The hearing loss remained unchanged. The trigeminal pain disappeared over a period of several weeks. Patients can be harmed in an attempt to remove these neurovascular nonmalignant, generally non growing, fatty vascular lumps. Only a partial, meticulous removal should be performed with a maximum effort to decompress the affected nerve.


Subject(s)
Cerebellopontine Angle/pathology , Decompression, Surgical/methods , Lipoma/complications , Nerve Compression Syndromes/etiology , Trigeminal Nerve Injuries , Trigeminal Neuralgia/etiology , Adolescent , Basilar Artery/pathology , Basilar Artery/physiopathology , Basilar Artery/surgery , Cerebellopontine Angle/blood supply , Cerebellopontine Angle/surgery , Cerebellum/blood supply , Cerebellum/pathology , Cerebellum/physiopathology , Cochlear Nerve/injuries , Cochlear Nerve/physiopathology , Cochlear Nerve/surgery , Deafness/etiology , Deafness/pathology , Deafness/surgery , Decompression, Surgical/adverse effects , Facial Nerve Injuries/etiology , Facial Nerve Injuries/physiopathology , Facial Nerve Injuries/surgery , Female , Humans , Lipoma/pathology , Lipoma/surgery , Magnetic Resonance Imaging , Nerve Compression Syndromes/pathology , Nerve Compression Syndromes/surgery , Recovery of Function/physiology , Tomography, X-Ray Computed , Treatment Outcome , Trigeminal Nerve/physiopathology , Trigeminal Nerve/surgery , Trigeminal Neuralgia/pathology , Trigeminal Neuralgia/surgery
18.
Eur J Pharmacol ; 406(2): 219-25, 2000 Oct 13.
Article in English | MEDLINE | ID: mdl-11020484

ABSTRACT

Erythropoietin exerts a neuroprotective effect during cerebral ischemia. We investigated the effect of systemic administration of recombinant human erythropoietin in a rabbit model of subarachnoid hemorrhage-induced acute cerebral ischemia. The animals were divided into three groups: group 1, subarachnoid hemorrhage; group 2, subarachnoid hemorrhage plus placebo; group 3, subarachnoid hemorrhage plus recombinant human erythropoietin (each group, n=8). Experimental subarachnoid hemorrhage was produced by injecting autologous blood into the cisterna magna. Treatment with recombinant human erythropoietin and placebo was started 5 min after subarachnoid hemorrhage and was continued every 8 h for 24 h. Before the animals were killed, erythropoietin concentration was measured in the cerebrospinal fluid. The rabbits were killed 24 h after subarachnoid hemorrhage and ischemic brain injury was histologically evaluated. In group 3, the concentration of erythropoietin in the cerebrospinal fluid was significantly increased and a significant reduction in cortical necrotic neuron count was also observed. These findings may encourage the use of erythropoietin in the treatment of cerebral ischemia that often occurs in the early stage of subarachnoid hemorrhage.


Subject(s)
Brain Ischemia/prevention & control , Erythropoietin/therapeutic use , Subarachnoid Hemorrhage/drug therapy , Animals , Blood-Brain Barrier , Calcium/metabolism , Erythropoietin/pharmacokinetics , Male , Rabbits , Recombinant Proteins
19.
Neurosurgery ; 47(3): 768-71; discussion 771-2, 2000 Sep.
Article in English | MEDLINE | ID: mdl-10981767

ABSTRACT

OBJECTIVE AND IMPORTANCE: Spasmodic torticollis is a neuromuscular disorder characterized by uncontrollable clonic and intermittently tonic spasm of the neck muscles. We report a case of spasmodic torticollis attributable to neurovascular compression of the right XIth cranial nerve by the right anteroinferior cerebellar artery (AICA). CLINICAL PRESENTATION: A 72-year-old man with a 2-year history of right spasmodic torticollis underwent magnetic resonance imaging, which demonstrated compression of the right XIth cranial nerve by an abnormal descending loop of the right AICA. INTERVENTION: The patient underwent microvascular decompression surgery. During surgery, it was confirmed that an abnormal loop of the right AICA was compressing the right accessory nerve. Compression was released by the interposition of muscle between the artery and the nerve. CONCLUSION: The patient's postoperative course was uneventful, and his symptoms were fully relieved at the 2-year follow-up examination. This is the first reported case of spasmodic torticollis attributable to compression by the AICA; usually, the blood vessels involved are the vertebral artery and the posteroinferior cerebellar artery.


Subject(s)
Accessory Nerve Diseases/complications , Cerebellum/blood supply , Nerve Compression Syndromes/complications , Torticollis/etiology , Accessory Nerve Diseases/diagnosis , Accessory Nerve Diseases/surgery , Aged , Arteries/pathology , Arteries/surgery , Decompression, Surgical , Diagnosis, Differential , Follow-Up Studies , Humans , Magnetic Resonance Angiography , Magnetic Resonance Imaging , Male , Microsurgery , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/surgery , Torticollis/surgery
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