ABSTRACT
BACKGROUND: Several investigations suggested correlation between microscopic colitis (MC) and celiac disease (CD). This study aimed to examine this relationship using large-sized, population-based data with adequate control for confounding factors. METHODS: This study employed the National Inpatient Sample (NIS) database over 4 years (2016-2019). Patients with/without MC in the presence/absence of CD were identified through ICD-10 codes. Univariate and multi-variate analyses involving odds ratios (OR) and 95% confidence intervals (CI) were performed. RESULTS: Overall, 26,836,118 patients were analyzed. Of whom, 6,836 patients had MC (n = 179 with CD and n = 6,657 without CD). The mean hospital stay was not significantly different between both groups (5.42 ± 5.44 days vs. 4.95 ± 4.66 days, P = 0.202). The univariate analysis revealed a significant association between MC and CD (OR = 22.69, 95% [19.55, 26.33], P < 0.0001). In the multi-variate analysis, which adjusted for potential confounders including age, race, hospital region, hospital teaching status, ZIP income, smoking status, alcohol overuse, hypertension, diabetes mellitus, lipidemia-related disorders, non-steroidal anti-inflammatory drug use, and selected auto-immune diseases, the association remained significant (OR = 15.71, 95% CI [13.52, 18.25], P < 0.0001). Moreover, in patients with MC, the presence of CD emerged as a significant, independent variable of in-hospital mortality in univariate (OR = 2.87, 95% [1.14, 7.21], P = 0.025) and multi-variate (OR = 3.37, 95% CI [1.32, 8.60], P = 0.011) analyses. CONCLUSION: This study establishes a probable link between MC and CD, backed by both univariate and multi-variate analyses, while also identifying CD as an independent risk factor for increased mortality among MC patients. These findings need to be validated in real-world clinical studies.
ABSTRACT
Infancy has been proven as the best time to improve health outcomes for the later stage of life. The composition of human breast milk has evolved over millennia to support and maintain the infant's life during the early years of life. To achieve life-sustaining effects, human breast milk is packed with fats, proteins, carbohydrates, and a wide range of bioactive compounds such as immunoglobulins, lactoferrin, and cytokines. The immunological compounds in breast milk have been shown to curtail gastrointestinal tract infections, respiratory tract infections, hospital admissions, acute otitis media, allergic reactions, and urinary tract infections. Although breastfeeding causes newborns to gain less weight at the beginning of their lives than formula milk does, breast milk improves body composition by low adiposity. A higher adipose deposition in infants is linked with an increased risk of child obesity in the future. Due to significant health benefits, the World Health Organization (WHO) recommends initiating breastfeeding within one hour after birth and continuing for at least six months. Breastfeeding has emerged as a superior source of nutrition that can promote healthy physiological and cognitive development and protect against disease challenges in low birthweight infants. This review summarizes potential evidence that highlights the potential health impact of breast milk in low birthweight infants.
ABSTRACT
Emphysematous pyelonephritis (EPN) is a rare life-threatening gas producing kidney infection, commonly affects uncontrolled diabetic patients with underlying urinary tract obstruction. Presence of pneumoperitoneum and involvement of the bowels are uncommon presentation of EPN. In the present report, we present a 59-year-old African male who had extensive EPN with pneumoperitoneum, pneumatosis intestinalis and extension to the bowel causing ischemia. Successful surgical exploration was done, with resection anastomosis of the ischemic bowel segment and drainage of the kidney.
ABSTRACT
INTRODUCTION: There is an increasing awareness regarding meal timing and chronotype. The present study aimed to assess breakfast skipping, late dinner intake, and chronotype among Saudi medical students. METHODS: A cross-sectional study was conducted among 169 clinical phase medical students during the period from January to May 2017. A self-administered questionnaire was used to report the frequency and timing of breakfast and dinner. In addition, the previous cumulative grade average, bedtime, wake-up time, and sleep duration during working days and weekends were reported. The chronotype was calculated from mid-sleep and wakeup time during weekends and sleep dept. The student's weight and height were measured to assess the body mass index (BMI). Participants also completed a diary detailing their sleep habits for two weeks before filling out the questionnaire. The chi-square and Pearson's correlation were used for the statistical analysis. RESULTS: Out of 169 medical students (48.5% males), their age was 22.90±1.27 years, 42% were breakfast-skippers, while 49.7% were late dinner consumers. No correlation was found between the previous cumulative grades (GPA), BMI, chronotype, and time lag in wakeup and bedtime between weekdays and weekends (p>0.005). No significant statistical differences between breakfast-skippers and late dinner consumers and their counterparts regarding GPA and chronotype. CONCLUSION: Breakfast skipping and late dinner consumption were prevalent among medical students in Tabuk, Saudi Arabia, future large sample case-control studies to assess the impact of meal timing, and chronotype on academic performance are highly recommended.
