SURGICAL INTERVENTION IN PATIENTS WITH IDIOPATHIC INFLAMMATORY BOWEL DISEASE AND PERIANAL DISEASE.

OBJECTIVE: Aim: The aim of the study was to investigate the incidence of IBD in gastrointestinal surgery patients and record the disease's characteristics and treatment. PATIENTS AND METHODS: Materials and Methods: A search was carried out in the archives of the gastroenterology clinics of the University General Hospital of Ioannina and the General Hospital of Ioannina "G. Hatzikosta" in Greece. All cases of operated patients from 1980 to 2018 were examined. The duration of the study was 4 months. Data were analyzed with the SPSS program, v.28. RESULTS: Results: The total sample consisted of 1464 patients (n=1464). Most of them (915-62.5%) came from the University General Hospital of Ioannina, while the rest (549-37.5%) came from the GHI hospital "G. Hatzikosta". The mean age of the patients was 47 years (M=47.26, SD=17.34, Min=<1 month, Max=95 years). From the total sample, 58 patients (4%) suffered from IBD; most were men (42-72.41%). Their mean age was approximately 50 years (M=49.63, SD=16.48, Min=25 years, Max=77 years, range=52 years) and most belonged to the age groups of 31-40 years (11 patients- 19.6%) and 21-30 years and 61-70 years (10 patients-17.9%). The perianal disease was present in 43.1% (25 patients). The most frequent type of operation was fistula resection, ligation, curettage-biopsy (24.1%) and opening-drainage (22.4%-13 patients) and the most frequent type of anesthesia was general anesthesia (93.1%-54 patients). CONCLUSION: Conclusions: This long-term study of the patients' data followed up over time showed that the possibility of surgery in patients with IBD is mitigated through systematic monitoring and multifaceted therapeutic treatment.The perianal disease which appeared more often in men shows that it can be diagnosed early and at an early stage and with the new minimally invasive techniques the patient with IBD can be treated with a better quality of life.

IS THERE AN ASSOCIATION BETWEEN HEALTH LITERACY AND ADHERENCE TO THE MEDITERRANEAN DIET? A CROSS-SECTIONAL STUDY IN GREECE.

OBJECTIVE: The aim: To evaluate the relationship between adherence to the Mediterranean diet and health literacy and to find possible differences based on the demographic characteristics of the participants. PATIENTS AND METHODS: Materials and methods: A cross-sectional study was carried out with a convenience sample from the Greek general population (n=203). The questionnaires were distributed through the Google Forms platform, while some of them were given on hand. The questionnaire used included demographic information, questions about the participants' health status and nutrition habits and the Health Literacy Scale (HLS - EU-Q16) and the MedDietScore. The survey was conducted June - July 2022. The program SPSS v. 26.0 was used for the analysis of data. RESULTS: Results: The mean score in HLS-EU-Q16 was 12.08 (SD=4.17) (15.8%=inadequate level, 30% =problematic level, 54.2%=sufficient level). The mean score in Med DietScore was 31.54 (SD=4.84) and the majority (72.4%) had medium adherence to the Mediterranean diet. Concerning the HLS-EU-Q16, women and those who had not children, were not patients and used the Internet for finding health information had higher score. In contrast, widows/ers and those with elementary education had lower score. With regard to the Med DietScore, those who were patients and had normal weight had higher score than the rest categories. A negative correlation was found between age-HLS-EU-Q16 (r=-.605, p<.01) and between BMI-Med DietScore (r=-.142, p<.05). CONCLUSION: Conclusions: Most of the participants had sufficient level of health literacy and medium adherence to the Mediterranean diet. Furthermore, there was not a significant correlation between adherence to the Mediterranean diet and health literacy. Several demographic and medical characteristics impact the health literature level and the adherence to the Mediterranean diet. Future research is suggested to further evaluate the results of this study.

The efficacy of immunomodulators in the prevention and suppression of anti-drug antibodies to anti-tumor necrosis factor therapy in inflammatory bowel disease.

The development of biological agents against tumor necrosis factor (TNF) has revolutionized the management of inflammatory bowel disease (IBD), frequently achieving induction and maintenance of remission in both ulcerative colitis and Crohn's disease. However, a loss of response due to the development of anti-drug antibodies (ADA) is seen annually in approximately 20% of IBD patients receiving anti-TNF therapy. Current evidence suggests that the use of immunomodulators (IMM), such as thiopurines (azathioprine and 6-mercaptopurine) or methotrexate, may prevent or suppress ADA formation. In this article, we present a comprehensive review of the available literature regarding the efficacy of IMM in the prevention and suppression of ADA development to anti-TNF therapy in patients with IBD.