1.
Pharmazie
; 54(10): 783-4, 1999 Oct.
Article
in English
| MEDLINE
| ID: mdl-10563378
Subject(s)
Antidepressive Agents/chemical synthesis , Thiazepines/chemical synthesis , Animals , Antidepressive Agents/pharmacology , Antidepressive Agents/toxicity , Blepharoptosis/chemically induced , Blepharoptosis/prevention & control , Body Temperature/drug effects , Depressive Disorder/drug therapy , Lethal Dose 50 , Mice , Rats , Receptor, Serotonin, 5-HT2A , Receptors, Serotonin/drug effects , Receptors, Serotonin/metabolism , Receptors, Serotonin, 5-HT1 , Swimming/psychology , Tetrabenazine/antagonists & inhibitors , Thiazepines/pharmacology , Thiazepines/toxicity
2.
Pharmazie
; 53(2): 130-4, 1998 Feb.
Article
in English
| MEDLINE
| ID: mdl-9540110
ABSTRACT
A number of thieno and pyrazolo[2,1]benzothiazepine derivatives as well as several synthetic intermediate compounds were tested for acute toxicity and antidepressant activity in mice. Some of these compounds were effective in the tetrabenazine and Porsolt tests.
Subject(s)
Antidepressive Agents/chemical synthesis , Thiazepines/chemical synthesis , Adrenergic Uptake Inhibitors/pharmacology , Animals , Antidepressive Agents/pharmacology , Body Temperature/drug effects , Female , Hypnotics and Sedatives/pharmacology , Male , Mice , Motor Activity/drug effects , Pentobarbital/pharmacology , Sleep/drug effects , Structure-Activity Relationship , Swimming , Tetrabenazine/pharmacology , Thiazepines/pharmacology , Time Factors
3.
Arch Pharm (Weinheim)
; 327(11): 721-8, 1994 Nov.
Article
in English
| MEDLINE
| ID: mdl-7840737
ABSTRACT
As an extension of a previous work, in which a number of 4H-pyrrolo-[1,2-a]thieno[2,3-f][1,4]diazepines were described, a new series of derivatives of the isomeric pyrrolo[1,2-a]thieno[3,2-f]diazepines ring system has been synthesized. The products obtained, together with those reported in the previous paper, were tested for acute toxicity and CNS activity in mice.
