ABSTRACT
Investigation of 213 rats has shown that exposition containing normal plasma of erythrocytes, neutrophils or monocytes (physiological concentration) taken from the rats treated with prooxidant (lead acetate) or antioxidant (selmevite) causes corresponding increase or decrease of: a) both spontaneous aggregation and ATP-induced aggregation of thrombocytes, b) releasing P3 and P4 factors, c) their lipoperoxidation (LPO) intensity. The effect is released by LPO products released by erythrocytes and leucocytes into their environment. The efficacy of antioxidants (vitamins with antioxidant properties in particular) used for correcting hypercoagulative changes in oxidative stress in clinics is supposed to be due to their capacity for limiting lipidoxidation in erythrocytes, leukocytes and thrombocytes.
Subject(s)
Erythrocytes/metabolism , Homeostasis/drug effects , Lipid Peroxidation/drug effects , Monocytes/metabolism , Neutrophils/metabolism , Adenosine Diphosphate/pharmacology , Animals , Antioxidants/pharmacology , Blood Platelets/metabolism , Organometallic Compounds/pharmacology , Organophosphorus Compounds/pharmacology , Platelet Aggregation/drug effects , RatsABSTRACT
Experiments on albino rats revealed that activation or suppression of lipid peroxidation are accompanied by increase or decrease of intravascular blood coagulation. Altered lipid peroxidation influences platelet activity and this influences the rate of intravascular blood coagulation. It is possible that antioxidants may be used for correction of hemostasis under pathological conditions characterized by increased lipid peroxidation.
Subject(s)
Antioxidants/pharmacology , Blood Coagulation/physiology , Lipid Peroxidation/physiology , Animals , Blood Coagulation/drug effects , Hyperthyroidism/blood , Hyperthyroidism/metabolism , Hypothyroidism/blood , Hypothyroidism/metabolism , Lipid Peroxidation/drug effects , Male , Platelet Activation/drug effects , Platelet Activation/physiology , Rats , Thyroid Hormones/bloodABSTRACT
Experiments on a group of 308 rats showed that prooxidant (lead acetate) introduced per os with daily meals decreases the antioxidant potential (increases lipid peroxidation, LPO) and reduces tolerance with respect to thrombin (increases the level of intravascular blood coagulation markers). For the same treatment on the background of a vitamin - antioxidants preparations (complivit or selmevit), the level of changes was significantly decreased and the resistance to thrombin was increased. Selmevit (containing selenium) was more effective. It is concluded that complex vitamin--antioxidants preparations can be used for correcting hemostatic changes in cases of hyperoxidation.
Subject(s)
Antioxidants/pharmacology , Hemostasis/drug effects , Lipid Peroxidation/drug effects , Minerals/pharmacology , Vitamins/pharmacology , Animals , Drug Combinations , Hyperoxia/chemically induced , Hyperoxia/metabolism , Male , Organometallic Compounds/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
Forty-seven men aged from 38 to 74 years with lower limb obliterating atherosclerosis (III-IV degree, indication for surgery) were examined. Growth of lipoperoxides level, a decrease of antioxidant potential, activation of hemostasis were revealed. These phenomena intensified after bypass surgeries and persisted till discharge. Supplement of standard therapy with antioxidant selmevit limited degree of disturbances before and after surgery, accelerated normalization of hemostasis.
