ABSTRACT
There are conflicting results respecting the segmental tubular origin of renal oncocytomas, a type of tumour said to be highly differentiated and benign, though metastases have been described. The aim of this study was, by applying different lectins on renal cell carcinomas (n = 50) and oncocytomas (n = 12), to search for patterns which could indicate a specific segmental origin of oncocytomas and perhaps elucidate the differentiation of this tumour. The following lectins were applied: jacalin, peanut agglutinin (PNA), wheat germ agglutinin (WGA), phytohemagglutinin E (PHA-E), concanavalin A (Con A), and Dolichos biflorus agglutinin (DBA). The results show that oncocytomas are positive when jacalin, a Lectin that stains distal tubules and collecting tubules, is used, supporting the view that the tumour derives from distal or collecting tubules. The staining of the oncocytomas is generally polarized as in normal kidney tubules underlining that the tumour is highly differentiated. Two oncocytomas with aggressive behaviour showed areas with a diffuse pattern suggesting lower differentiation.
Subject(s)
Adenoma, Oxyphilic/metabolism , Carcinoma/metabolism , Kidney Neoplasms/metabolism , Lectins/metabolism , Adenoma, Oxyphilic/pathology , Carcinoma/pathology , Histocytochemistry , Humans , Kidney Neoplasms/pathologyABSTRACT
Two cases of symptom-producing balanoposthitis associated with Human papillomavirus infection are described. These patients had spotty, macular, erythematous rash on the glans penis and prepuce. The symptoms and objective findings resemble those of Candida infection but the diagnosis can be established by histological examination of biopsy from the acetowhite elements.
Subject(s)
Balanitis/diagnosis , Tumor Virus Infections/diagnosis , Adult , Balanitis/microbiology , Balanitis/pathology , Humans , Male , Papillomaviridae/isolation & purification , Tumor Virus Infections/microbiology , Tumor Virus Infections/pathologyABSTRACT
We report upon a 46-year-old woman, who developed immune complex disease after treatment with clonidine for one year. The diagnosis was verified with histological demonstration of IgG and IgM complexes as well as complement C1q, C3c and C4 between muscle fibres and at the dermo-epidermal junctions. The patient's symptoms abated and the abnormal results of blood tests reverted to normal following cessation of clonidine therapy.
