Subject(s)
Tuberculosis, Pulmonary/congenital , Tuberculosis, Pulmonary/epidemiology , Female , Humans , Infant , Infant, Newborn , Infectious Disease Transmission, Vertical , Pregnancy , Pregnancy Complications, Infectious/microbiology , Tuberculosis, Pulmonary/prevention & control , Tuberculosis, Pulmonary/transmissionSubject(s)
Abnormalities, Drug-Induced/etiology , Antifungal Agents/adverse effects , Candidiasis/drug therapy , Fluconazole/adverse effects , Pregnancy Complications, Infectious/therapy , Antifungal Agents/therapeutic use , Candidiasis, Vulvovaginal/drug therapy , Female , Fluconazole/therapeutic use , Humans , Infant, Newborn , PregnancyABSTRACT
We report the clinical course and CT and MRI findings in a case of heat-stroke-induced cerebellar atrophy. Although the cerebellar syndrome was severe concomitant with the onset of heat stroke, no abnormality was observed on brain CT in the first 2 weeks following the event. Cerebellar atrophy was first noted after 10 weeks on MRI; it was progressive during a 1-year follow-up.
Subject(s)
Cerebellum/pathology , Heat Exhaustion/diagnosis , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Atrophy , Brain Damage, Chronic/diagnosis , Follow-Up Studies , Humans , Male , Middle Aged , Neurologic ExaminationABSTRACT
A case in which prescription medications induced heat intolerance which led to heat stroke is presented. A subject who suffered from depression and was treated with fluoxetine HCL (prozac) and lithium carbonate was engaged in mild intermittent work for 4 hours under hot/dry climatic conditions (Ta = 37 degrees C, rh = 15%). The subject lost consciousness, was hyperthermic and suffered from disseminated intravascular coagulation. A year later residual cerebellar symptoms were still evident and severe atrophy of the cerebellar tissue was demonstrated in a CT scan. It is suggested that drug-induced heat intolerance was the predisposing factor that reduced the patient ability to sustain exercise-heat stress, and under the favorable environmental circumstances led to excessive heat accumulation which ultimately caused heat stroke. This is the first description, to our knowledge, of heat intolerance of a patient treated by a combination of fluoxetine and lithium carbonate.
Subject(s)
Antidepressive Agents/adverse effects , Body Temperature Regulation/drug effects , Fluoxetine/adverse effects , Heat Stress Disorders/etiology , Lithium/adverse effects , Drug Synergism , Humans , MaleSubject(s)
Heat Stroke/prevention & control , Physical Exertion , Sports , Heat Stroke/diagnosis , Heat Stroke/therapy , Hot Temperature , HumansSubject(s)
Antidepressive Agents, Second-Generation/adverse effects , Antidepressive Agents/adverse effects , Depression/drug therapy , Fluoxetine/adverse effects , Heat Stroke/etiology , Lithium/adverse effects , Selective Serotonin Reuptake Inhibitors/adverse effects , Body Temperature Regulation/drug effects , Drug Synergism , Humans , Male , Middle AgedABSTRACT
The antibiotic drug novobiocin was evaluated for its anti-tumour properties in B16 melanoma cells. Novobiocin is shown to inhibit melanoma B16 cell proliferation. The anti-proliferative effect was gradually reversible upon removal of novobiocin from the culture medium. Growth inhibition by novobiocin was accompanied by phenotypic alterations, that included morphological changes, lipid accumulation and marked increases in the activities of NADPH cytochrome c reductase and gamma glutamyl transpeptidase. In vivo administration of repeated i.p. doses of novobiocin, to mice implanted with B16 melanoma cells resulted in growth retardation. The combined treatment of the B16 melanoma cells with novobiocin and other chemical inducers of differentiation was examined in a cell growth assay. Novobiocin and sodium butyrate inhibited cell growth in a near additive manner, while combination of novobiocin with the GTP-depleting agents, tiazofurin or mycophenolic acid resulted in a synergistic decrease in cell growth. Our results support the contention further that novobiocin and other differentiating agents might be of potential value in melanoma therapy.
