Oral side effects of isotretinoin chronic intake.

Isotretinoin (13-cis-retinoic acid) is a retinoid that has been used for the past 20 years to treat a variety of dermatologic conditions. It is beneficial in many skin conditions, although its side effects and toxicity require careful monitoring by physicians and other health professionals, among them, dentists, who should be prepared to manage an adverse occurrence. In this paper, the oral side effects of isotretinoin are described; and some of them are illustrated.