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1.
Acta colomb. psicol ; 26(2)dic. 2023.
Article in English | LILACS-Express | LILACS | ID: biblio-1533380

ABSTRACT

Social networks, particularly Facebook, influence romantic relationships, as they can generate jealousy and conflict between members of the couple. The Facebook Jealousy Scale (FJS) is an instrument that assesses jealousy about using Facebook, but no similar instrument is available in Colombia. The main aim was to examine the psychometric properties of the FJS in a Colombian sample of 485 men and 727 women. Participants answered the socio-demographic questionnaire, the adaptation of the Facebook Jealousy Scale, Romantic Partner Conflict Scale, Rosenberg Self-Esteem Scale and Romantic Jealousy Scale. The final version of the FJS was made up of 15 items which were distributed across three dimensions: Partner's Activity, Partner's Surveillance, Partner's Romantic and Sexual relationship. Ordinal's alpha values from its three factors ranged between .90 and .95. Concurrent validity was also provided, as the measure was associated with dimensions from partner conflict, self-esteem, and romantic jealousy. An invariance test by gender was also performed, resulting in compliance with metric invariance. Therefore, the FJS is a useful tool for clinicians and researchers who work on issues related to romantic relationships. Research analyzing Facebook jealousy provides an interesting indicator of couple's monitoring and controlling behaviors, which are features of psychological abuse, a subtype of intimate partner violence.


Las redes sociales, particularmente Facebook, influyen en las relaciones sentimentales, ya que pueden generar celos y conflictos entre los miembros de la pareja. La Escala de Celos de Facebook (FJS) es un instrumento que evalúa los celos por el uso de Facebook, y no hay ningún instrumento similar disponible en Colombia. El objetivo principal fue examinar las propiedades psicométricas del FJS en una muestra colombiana de 485 hombres y 727 mujeres. Los participantes completaron un cuestionario sociodemográfico, la adaptación de la Escala de Celos de Facebook, la Escala de Conflicto de Pareja Romántica, la Escala de Autoestima de Rosenberg y la Escala de Celos Románticos. La versión final de la FJS estuvo conformada por 15 ítems que, a su vez, conformaron tres dimensiones: Actividad de la pareja, Vigilancia de la pareja, Relación romántica y sexual de la pareja. Los valores de alfa ordinal de los tres factores oscilaron entre .90 y .95. También se demostró validez concurrente con otras dimensiones relacionadas con conflicto en la pareja, autoestima y celos románticos. El análisis de invarianza según género resultó en un nivel de invarianza métrica. El FJS es una medida que puede ser útil para la práctica clínica y los investigadores que trabajan en temas relacionados con las relaciones románticas. La investigación que analice los celos asociados al Facebook ofrecerá un interesante indicador de la supervisión en el contexto de pareja y las conductas de control, elementos clave del abuso psicológico, un subtipo de la violencia de pareja.

2.
Geroscience ; 45(1): 159-175, 2023 02.
Article in English | MEDLINE | ID: mdl-35690689

ABSTRACT

Brain networks involved in working and spatial memory are closely intertwined, outlining a potential relation between these processes, which are also affected in non-pathological aging. Working memory is a pre-requisite for other complex cognitive processes. The main aim of this study is to explore how working memory capacity (WMC) can influence the asymmetrical decline in spatial orientation strategies in an older segment of population compared to young participants. Forty-eight older adults and twelve young students took part in the study. Working memory and spatial memory were assessed using the Change Localization Task and The Boxes Room Task, respectively. In The Boxes Room Task, two different configurations assessed the use of egocentric and allocentric reference frames. Results showed that older adults with better WMC outperformed those with lower WMC in several tasks. Independently of WMC capacity, older participants performed better in the allocentric condition of The Boxes Room. In addition, young participants outscored low WMC older participants, but did not differ from high WMC older adults. Overly, these findings support the important relationship between working memory capacity and spatial orientations abilities. Thus, basic cognitive mechanisms engaged in information processing could inform about other brain processes more complex in nature, like spatial orientation skills.


Subject(s)
Aging , Memory, Short-Term , Humans , Aged , Aging/psychology , Spatial Memory , Cognition
3.
Appetite ; 138: 184-189, 2019 07 01.
Article in English | MEDLINE | ID: mdl-30940610

ABSTRACT

Binge eating disorder (BED) is characterized, in part, by recurrent episodes of eating large quantities of food in a short period of time. Repetitive binge episodes are a common pattern of consumption during the early stages of substance abuse, and it has been proposed that binge patterns of consumption might favor the transition to BED and "food addiction". Therefore, it is of paramount importance to provide new behavioral strategies that protect vulnerable binge-prone individuals from transitioning to BED and food addiction. Recently, we showed protective and therapeutic benefits of environmental enrichment (EE) on binge-like intake of ethanol in C57BL/6J mice, in agreement with previous evidence showing EE modulation of drug intake, drug relapse and drug reward. In the present study, adolescent mice reared under EE conditions were evaluated for binge-like consumption of sucrose during adulthood in a long-term drinking in the dark (DID) procedure that effectively models binge consumption in humans. Additionally, we tested binge-like intake in adults reared under standard conditions (SE) with long-term exposure to sucrose DID and the effects on sucrose DID of switching from SE to EE conditions. We report here, for the first time, that early EE exposure protects mice from binge-like excessive sucrose intake during adulthood. Ongoing binge-like high sucrose intake in SE-reared mice was also significantly reduced when switched to EE conditions. The present observations suggest that EE exposure might be a promising tool for preventing repetitive binge-like sucrose consumption from transitioning to BED and food addiction.


Subject(s)
Binge-Eating Disorder/prevention & control , Binge-Eating Disorder/therapy , Environment , Play and Playthings/psychology , Reward , Sucrose/administration & dosage , Animals , Behavior, Animal , Binge-Eating Disorder/psychology , Disease Models, Animal , Male , Mice , Mice, Inbred C57BL
4.
Front Behav Neurosci ; 13: 27, 2019.
Article in English | MEDLINE | ID: mdl-30828291

ABSTRACT

Repetitive binge episodes favor transition to binge-eating disorders. Experimental evidence points to positive influence of environmental enrichment (EE) on drug/food addiction, although far less is known regarding EE effects over binge-like consumption. Here, we evaluate the following: (1) whether switching from nonenriched standard environment (SE) to EE housing conditions during adulthood alters a stable pattern of voluntary sucrose (10% w/v) binge-like intake in high (HD) vs. low (LD) drinking phenotypes under a drinking in the dark (DID) schedule; and (2) sucrose binge-like intake in a DID task in response to a pharmacological challenge with an OXr1 antagonist in HD/LD subpopulations after long-term exposure to SE or EE conditions. Adolescent (postnatal day 21; PND21) mice were housed in SE conditions. At PND65, all animals were long-term exposed to sucrose DID. On the first episode of DID (PND65), animals were divided into HD vs. LD subpopulations according to their sucrose intake. On PND85, an OXr1 antagonist test was conducted on HD and LD mice with SB-334867 (SB) administration. On PND95, HD and LD subpopulations were again randomly allocated into two subgroups, resulting in the following experimental conditions: HD-SE, HD-EE, LD-SE and LD-EE. Sucrose binge-like intake continued until PND116, when a second SB test was conducted. The main findings are: (1) a single 2 h episode of sucrose binge drinking in a DID procedure consistently segregates two behavioral subpopulations, HD and LD; (2) when adult mice in standard conditions and long-term exposed to sucrose DID were switched to EE conditions, an immediate reduction in sucrose binge-like intake was observed in HD mice, pointing to a therapeutic role of EE exposure; and (3) administration of the OXr1 antagonist caused an acute reduction in sucrose binge-like intake in HD and LD mice exposed to SE conditions. Importantly, exposure to EE conditions blunted the inhibitory effect of SB on sucrose binge consumption in both behavioral phenotypes, indirectly suggesting a potential EE/OXr1 signaling interaction. We propose the hypothesis that EE might regulate OX-dependent anxiety/compulsivity brain systems, which might secondarily modulate sucrose binge-like intake.

5.
Sci Rep ; 8(1): 9925, 2018 07 02.
Article in English | MEDLINE | ID: mdl-29967375

ABSTRACT

Transcriptional dysregulation in Huntington's disease (HD) affects the expression of genes involved in survival and neuronal functions throughout the progression of the pathology. In recent years, extensive research has focused on epigenetic and chromatin-modifying factors as a causative explanation for such dysregulation, offering attractive targets for pharmacological therapies. In this work, we extensively examined the gene expression profiles in the cortex, striatum, hippocampus and cerebellum of juvenile R6/1 and N171-82Q mice, models of rapidly progressive HD, to retrieve the early transcriptional signatures associated with this pathology. These profiles were largely consistent across HD datasets, contained tissular and neuronal-specific genes and showed significant correspondence with the transcriptional changes in mouse strains deficient for epigenetic regulatory genes. The most prominent cases were the conditional knockout of the lysine acetyltransferase CBP in post-mitotic forebrain neurons, the double knockout of the histone methyltransferases Ezh1 and Ezh2, components of the polycomb repressor complex 2 (PRC2), and the conditional mutants of the histone methyltransferases G9a (Ehmt2) and GLP (Ehmt1). Based on these observations, we propose that the neuronal epigenetic status is compromised in the prodromal stages of HD, leading to an altered transcriptional programme that is prominently involved in neuronal identity.


Subject(s)
Brain/metabolism , Epigenesis, Genetic , Huntington Disease/genetics , Neurons/metabolism , Transcriptome , Animals , Cerebellum/metabolism , Cerebral Cortex/metabolism , Corpus Striatum/metabolism , Disease Models, Animal , Female , Gene Expression Regulation , Hippocampus/metabolism , Male , Mice
6.
Front Behav Neurosci ; 11: 186, 2017.
Article in English | MEDLINE | ID: mdl-29066961

ABSTRACT

Ethanol (EtOH) research has focused on stages of dependence. It is of paramount importance to more deeply understand the neurobehavioral factors promoting increased risk for EtOH binge drinking during the early stages of the addiction cycle. The first objective of this study was to evaluate whether C57BL/6J mice showing high drinking in the dark (DID) exhibit neurobehavioral traits known to contribute to EtOH binge-drinking disorders. Comparing high vs. low drinkers (HD/LD), we evaluated different types of basal anxiety-like responses, EtOH preference and sensitivity to the reinforcing properties of EtOH, and basal mRNA expression of the OX1/OX2 receptors (OX1r/OX2r) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc). Additionally, we tested binge drinking by LD/HD in response to a selective OX1r antagonist following intermittent episodes of DID (iDID). We report that DID consistently segregates two neurobehavioral endophenotypes, HD vs. LD, showing differences in neophobia and/or impulsivity/compulsivity traits. Additionally, HD mice show decreased basal OX1r and OX2r mRNA expression within the NAcc and elevated OX1r within the PFC. Exposure to several intermittent episodes of EtOH DID triggered a rapid increase in EtOH intake over time in LD mice matching that observed in HD mice. Despite HD/LD endophenotypes did not show differences in EtOH intake, they still predicted the response to a pharmacological challenge with a selective OX1r antagonist. The present data underscore the relevance of HD/LD endophenotypes stemming from DID procedures for exploring neurobehavioral processes underlying the early stages of the addiction cycle and EtOH binge-drinking disorders.

7.
Front Behav Neurosci ; 11: 167, 2017.
Article in English | MEDLINE | ID: mdl-28936166

ABSTRACT

The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol palatability in adult rats. Ethanol exposure during adolescence causes long-lasting changes in neural pathways critically involved in neurobehavioral responses to ethanol. In this regard, binge-like ethanol exposure during adolescence reduces basal alpha-melanocyte-stimulating hormone (α-MSH) and alters the levels of agouti-related peptide (AgRP) in hypothalamic and limbic areas. Given the protective role of MC against excessive ethanol consumption, disturbances in the MC system induced by binge-like ethanol exposure during adolescence might contribute to excessive ethanol consumption during adulthood. In the present study, we evaluated whether binge-like ethanol exposure during adolescence leads to elevated ethanol intake and/or eating disturbance during adulthood. Toward that aim, Sprague-Dawley rats were treated with ethanol (3 g/kg i.p.; BEP group) or saline (SP group) for 14 days (PND 25 to PND 38). On PND73, all the groups were given access to 20% ethanol on an intermittent schedule. Our results showed that adult rats given intermittent access (IAE) to 20% ethanol achieved high spontaneous ethanol intake that was not significantly enhanced by binge-like ethanol pretreatment during adolescence. However, BEP group exhibited an increase in food intake without a parallel increase in body weight (BW) relative to SP group suggesting caloric efficiency disturbance. Additionally, we evaluated whether binge-like ethanol exposure during adolescence alters the expected reduction in feeding and ethanol consumption following NAc shell administration of a selective MC4-R agonist in adult rats showing high rates of ethanol consumption. For that, animals in each pretreatment condition (SP and BEP) were divided into three subgroups and given bilateral NAc infusions of the selective MC4-R agonist cyclo(NH-CH2-CH2-CO-His-D-Phe-Arg-Trp-Glu)-NH2 (0, 0.75 or 1.5 µg). Results revealed that MC4-R stimulation within the NAc reduced feeding and ethanol intake in high ethanol-drinking adult rats, regardless of previous binge-like ethanol exposure during adolescence, which adds new evidence regarding the dual ability of MC compounds to control excessive ethanol and food intake.

8.
Pharmacol Biochem Behav ; 134: 31-4, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25931265

ABSTRACT

Orexins (OX) are neuropeptides synthesized in the lateral hypothalamic region which play a fundamental role in a wide range of physiological and psychological functions including arousal, stress, motivation or eating behaviors. This paper reviews under the addiction cycle framework (Koob, 2010), the role of the OX system as a key modulator in compulsivity-driven consumption of rewarding stimulus including ethanol, palatable food and drugs and their role in impulsivity and binge-like consumption in non dependent organisms as well. We propose here that drug/food binge-like consumption in vulnerable organisms increases OX activity which, in turn, elicits enhanced impulsivity and further impulsivity-driven binge consumption in a positive loop that would promote compulsive-driven binge-consumption and the transition to drug/food disorders over time.


Subject(s)
Orexins/physiology , Reward , Substance-Related Disorders/psychology , Animals , Humans
9.
Behav Brain Res ; 287: 230-7, 2015.
Article in English | MEDLINE | ID: mdl-25827928

ABSTRACT

Orexins (OX) have been recently implicated in ethanol seeking and self-administration. A few recent studies have provided additional evidence that OX receptor antagonists effectively reduce voluntary ethanol consumption in subjects spontaneously showing high levels of ethanol intake. The present study further evaluates the contribution of OXR1 to excessive binge-like drinking of ethanol in ad libitum-fed C57BL/6J mice from a pharmacological and molecular approach. The main findings in the study are: (1) Icv administration of SB-334867 (3 µg/µl) blunted ethanol (20% v/v), but not saccharin (0.15% w/v) binge-like drinking in a drinking in the dark procedure, without any alteration of chow consumption or total calories ingested; (2) Icv administration of SB-334867 (3 µg/µl) increased the latency to recover the righting reflex after a sedative dose of ethanol without any significant alteration in ethanol peripheral metabolism; (3) four repetitive, 2-h daily episodes of saccharin, but not ethanol binge-like drinking blunted OXR1 mRNA expression in the lateral hypothalamus. Present findings extend the current knowledge pointing to a role for OX signaling in ethanol sedation, which might partially explain the inhibitory effect of OXR1 antagonists on ethanol consumption. Combined pharmacological and molecular data suggesting the contribution of OXR1 in ethanol binge-drinking leading us to propose the idea that targeting OXR1 could represent a novel pharmacological approach to control binge-consumption episodes of ethanol in vulnerable organisms failing to spontaneously reduce OX activity.


Subject(s)
Binge Drinking/drug therapy , Binge Drinking/metabolism , Central Nervous System Depressants/administration & dosage , Ethanol/administration & dosage , Orexin Receptors/metabolism , Animals , Benzoxazoles/pharmacology , Blood Alcohol Content , Drinking Water/administration & dosage , Eating/drug effects , Eating/physiology , Hypnotics and Sedatives/pharmacology , Hypothalamic Area, Lateral/drug effects , Hypothalamic Area, Lateral/metabolism , Locomotion/drug effects , Locomotion/physiology , Male , Mice, Inbred C57BL , Naphthyridines , Orexin Receptor Antagonists/pharmacology , RNA, Messenger/metabolism , Reflex/drug effects , Reflex/physiology , Saccharin/administration & dosage , Urea/analogs & derivatives , Urea/pharmacology
10.
Behav Brain Res ; 272: 93-9, 2014 Oct 01.
Article in English | MEDLINE | ID: mdl-24983661

ABSTRACT

The orexin (OX) system has been implicated in food-reinforced behavior, food-seeking and food overconsumption. Recent evidence suggests that OX signaling might influence consumption of palatable foods with high reinforcing value depending upon the caloric status of the animal. The present study evaluates from a pharmacological and a molecular approach the contribution of OX to excessive binge-like consumption of highly preferred palatable substances (sucrose and saccharin) in ad libitum-fed C57BL/6J mice. The main findings of this study are: (1) intraperitoneal (ip) injection of SB-334867 (10, 20 or 30mg/kg), a selective OXR1 antagonist, significantly decreased binge-like consumption of sucrose (10%, w/v) and saccharin (0.15%, w/v) during the test day in a Drinking in the Dark procedure in ad libitum-fed animals, without evidence of any significant alteration of locomotor activity. (2) Four repetitive, 2-h daily episodes of sucrose and saccharin (but not water) binge-like drinking significantly dampened OX mRNA expression in the LH. Present findings show for the first time a role for OXR1 signaling in binge-like consumption of palatable substances in animals under no caloric needs. Targeting OXR1 could represent a novel pharmacological approach to treat binge-eating episodes.


Subject(s)
Drinking Behavior/drug effects , Drinking Behavior/physiology , Energy Intake/drug effects , Energy Intake/physiology , Intracellular Signaling Peptides and Proteins/metabolism , Neuropeptides/metabolism , Animals , Benzoxazoles/pharmacology , Bulimia , Dietary Sucrose/administration & dosage , Dose-Response Relationship, Drug , Drinking Water/administration & dosage , Hypothalamic Area, Lateral/drug effects , Hypothalamic Area, Lateral/physiology , Male , Mice, Inbred C57BL , Mitochondrial Proteins/antagonists & inhibitors , Mitochondrial Proteins/metabolism , Motor Activity/drug effects , Motor Activity/physiology , Naphthyridines , Neurotransmitter Agents/pharmacology , Nuclear Proteins/antagonists & inhibitors , Nuclear Proteins/metabolism , Orexins , RNA, Messenger/metabolism , Saccharin/administration & dosage , Urea/analogs & derivatives , Urea/pharmacology
11.
Nat Commun ; 5: 4450, 2014 Jul 18.
Article in English | MEDLINE | ID: mdl-25034090

ABSTRACT

The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized functions. To investigate neuronal chromatin organization and dynamics in vivo, we generated bitransgenic mice expressing GFP-tagged histone H2B in principal neurons of the forebrain. Surprisingly, the expression of this chimeric histone in mature neurons caused chromocenter declustering and disrupted the association of heterochromatin with the nuclear lamina. The loss of these structures did not affect neuronal viability but was associated with specific transcriptional and behavioural deficits related to serotonergic dysfunction. Overall, our results demonstrate that the 3D organization of chromatin within neuronal cells provides an additional level of epigenetic regulation of gene expression that critically impacts neuronal function. This in turn suggests that some loci associated with neuropsychiatric disorders may be particularly sensitive to changes in chromatin architecture.


Subject(s)
Behavior, Animal/physiology , Chromatin/ultrastructure , Neurons/physiology , Serotonin/metabolism , Animals , Cell Nucleus/genetics , Cell Nucleus/metabolism , Cell Nucleus/ultrastructure , Chromatin/chemistry , Chromatin/genetics , Epigenesis, Genetic , Euchromatin/metabolism , Euchromatin/ultrastructure , Gene Expression Regulation , Green Fluorescent Proteins/genetics , Green Fluorescent Proteins/metabolism , Heterochromatin/metabolism , Histones/genetics , Histones/metabolism , Mice, Inbred C57BL , Mice, Transgenic , Neurons/metabolism , Neurons/ultrastructure , Prosencephalon/metabolism , Prosencephalon/pathology , Receptors, Serotonin/genetics , Transcription, Genetic
12.
Int. j. morphol ; 32(2): 575-582, jun. 2014. ilus
Article in English | LILACS | ID: lil-714312

ABSTRACT

Binge alcohol drinking during adolescence has been associated with neurotoxicity and increased risk for the development of alcohol use disorders. There is evidence that acute and chronic ethanol administration alters c-fos expression, an indirect index of cellular activity, in different brain regions in adult rats. We evaluate here if a binge-like pattern of ethanol exposure during adolescence has a relevant impact on basal and/or ethanol-stimulated regional c-fos activity during adulthood. For that aim, Sprague-Dawley rats PND 25 were saline pre-treated, (SP group) or binge-ethanol pre-treated (BEP group) for two­consecutive days, at 48-h intervals, over a 14-day period (PND 25 to PND 38). At adult stage (PND 63) and following 25 ethanol-free days, we evaluated c-fos immunoreactivity in response to saline or acute ethanol (1.5 or 3.0 g/kg) in the hypothalamus and amygdala. We found that acute ethanol administration dose-dependently increased c-fos activity in the the Paraventricular nucleus of the hypothalamus (PVN). Interestingly, binge-ethanol exposure during adolescence significantly reduced basal c-fos activity during adulthood in the Central nucleus of the amygdala (CeA) and the Arcuate nucleus of hypothalamus (Arc). We conclude that binge-like ethanol administration during adolescence causes long-term disturbances in basal neural activity in brain areas critically involved with ethanol consumption.


El consumo en atracón durante la adolescencia está asociado con neurotoxicidad y con el riesgo de desarrollar un trastorno en el uso de alcohol. Diversos estudios muestran que la administración aguda y crónica de alcohol en ratas adultas altera la expresión de c-fos, un marcador indirecto de actividad celular, en diferentes áreas cerebrales. Nosotros evaluamos si el patrón de consumo de alcohol en atracón durante la adolescencia tiene un impacto en la actividad basal de c-fos en esas regiones activadas por el alcohol. Utilizamos ratas Sprague-Dawley en su día post-natal 25 (PND25) tratadas con suero salino (grupo SP) o con etanol tipo atracón (grupo BEP) durante dos días consecutivos, en intervalos de 48 h, durante 14 días (PND25- PND38). En la edad adulta (PND63) y después de 25 días sin etanol, evaluamos la inmunorreactividad para c-fos en respuesta a una administración aguda de suero salino o etanol (1,5 ó 3,0 g/kg) en diferentes regiones cerebrales. La administración de alcohol incrementó de manera dosis-dependiente la actividad de c-fos en el núcleo paraventricular del hipotálamo. Además la exposición a etanol tipo atracón durante la adolescencia disminuyó la actividad basal de c-fos en la adultez en el núcleo central de la amígdala y en el núcleo arqueado del hipotálamo. Concluimos que el consumo de alcohol en atracón durante la adolescencia causa problemas a largo plazo en la actividad basal de regiones cerebrales implicadas en el consumo de alcohol.


Subject(s)
Animals , Rats , Paraventricular Hypothalamic Nucleus/drug effects , Arcuate Nucleus of Hypothalamus/drug effects , Proto-Oncogene Proteins c-fos/drug effects , Ethanol/administration & dosage , Central Amygdaloid Nucleus/drug effects , Immunohistochemistry , Age Factors , Ethanol/pharmacology
13.
Pharmacol Biochem Behav ; 110: 66-74, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23792540

ABSTRACT

Melanocortins (MC) are central peptides that have been implicated in the modulation of ethanol consumption. There is experimental evidence that chronic ethanol exposure reduces α-MSH expression in the limbic and hypothalamic brain regions and alters central pro-opiomelanocortin (POMC) mRNA activity in adult rats. Adolescence is a critical developmental period of high vulnerability in which ethanol exposure alters corticotropin releasing factor, neuropeptide Y, substance P and neurokinin neuropeptide activities, all of which have key roles in ethanol consumption. Given the involvement of MC and the endogenous inverse agonist AgRP in ethanol drinking, here we evaluate whether a binge-like pattern of ethanol treatment during adolescence has a relevant impact on basal and/or ethanol-stimulated α-MSH and AgRP activities during adulthood. To this end, adolescent Sprague-Dawley rats (beginning at PND25) were pre-treated with either saline (SP group) or binge-like ethanol exposure (BEP group; 3.0 g/kg given in intraperitoneal (i.p.) injections) of one injection per day over two consecutive days, followed by 2 days without injections, repeated for a total of 8 injections. Following 25 ethanol-free days, we evaluated α-MSH and AgRP immunoreactivity (IR) in the limbic and hypothalamic nuclei of adult rats (PND63) in response to ethanol (1.5 or 3.0 g/kgi.p.) and saline. We found that binge-like ethanol exposure during adolescence significantly reduced basal α-MSH IR in the central nucleus of the amygdala (CeA), the arcuate nucleus (Arc) and the paraventricular nucleus of the hypothalamus (PVN) during adulthood. Additionally, acute ethanol elicited AgRP IR in the Arc. Rats given the adolescent ethanol treatment required higher doses of ethanol than saline-treated rats to express AgRP. In light of previous evidence that endogenous MC and AgRP regulate ethanol intake through MC-receptor signaling, we speculate that the α-MSH and AgRP disturbances induced by binge-like ethanol exposure during adolescence may contribute to excessive ethanol consumption during adulthood.


Subject(s)
Age Factors , Amygdala/drug effects , Ethanol/administration & dosage , Hypothalamus/drug effects , alpha-MSH/metabolism , Amygdala/metabolism , Animals , Body Weight/drug effects , Ethanol/blood , Ethanol/pharmacology , Hypothalamus/metabolism , Rats , Rats, Sprague-Dawley
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