ABSTRACT
Contribution of 60 patients with primary surface transitional cell tumours of the bladder where nuclear expression of p53 protein was prospectively studied and compared to known prognostic factors in an attempt to find out its role in the development of relapses. An statistically significant relationship was found between the protein expression and cytology, tumoral multifocality, stage, relapse development and tumoral progression. It can be concluded that expression of this protein can be of use as relapse predictor.
Subject(s)
Carcinoma, Transitional Cell/genetics , Gene Expression Regulation, Neoplastic , Genes, p53/genetics , Neoplasm Recurrence, Local/epidemiology , Urinary Bladder Neoplasms/genetics , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Presentamos 60 casos de pacientes con tumores vesicales superficiales primarios de células transicionales, en los cuales hemos estudiado de forma prospectiva la expresión nuclear de la proteína p53, y la hemos comparado con factores pronósticos conocidos, intentando averiguar asimismo su papel en la aparición de recidivas. Se ha observado la existencia de una relación estadísticamente significativa entre dicha expresión y la citología, la multifocalidad tumoral, el estadio, la aparición de recidivas y la progresión tumoral. Podemos concluir que la expresión de esta proteína puede ser útil como factor predictor de las recidivas. (AU)
Subject(s)
Middle Aged , Aged, 80 and over , Aged , Male , Female , Humans , Gene Expression Regulation, Neoplastic , Genes, p53 , Prospective Studies , Carcinoma, Transitional Cell , Neoplasm Recurrence, Local , Urinary Bladder NeoplasmsABSTRACT
Presentation of 113 cases of transitional cells surface tumours of the bladder where p53 protein expression has been used and compared to known prognostic factors. The existence of a statistically significant relationship between this expression and the tumoral grade and stage in all studied groups has been noticed. It can be concluded that the expression of this protein can be useful as a new prognostic factor, even though it is still necessary to conduct more studies, basically prospective.
