[Endometrial hyperplasia, diagnosis. Clinical, paraclinical exam and management]. / Metodologia diagnosticului hiperplaziilor endometriale examen clinic, paraclinic si management.

UNLABELLED: Factors associated with unopposed estrogenic stimulation such as obesity, exogenous hormone use endometrial hyperplasia are related to the development of the most common form of endometrial carcinoma, that is, the endometroid subtype. MATERIAL AND METHODS: We selected a group of patients diagnosed with endometrial hyperplasia by endometrial biopsy and histopathological examination. The main complaint in all cases was abnormal uterine bleeding. All patients had gynecological examination, vaginal ultrasound, hysteroscopy endometrial biopsy or D&C. 32 patients had also immunohistochemical staining for Ki67, EGF, ER, PGR. RESULTS: Cases with ages between 24-67 years were classified as: 100 simple hyperplasia, 10 complex hyperplasia, 43 atypical simple hyperplasia, 7 atypical complex hyperplasia. PR were 40-60% at all forms of hyperplasia, E2R were 30-40% in simple hyperplasia without atypia and 50-70% in complex hyperplasia without atypia. Correlation between immunohistochemical expression of E2R, PGR, Ki-67, EGF and body mass revealed an high immunohistochemical expression of E2R and Ki-67 in patients with hyperplasia without atypia and a low expression and high reactivity of EGF in cases with high body mass. CONCLUSIONS: Vaginal ultrasound and hysteroscopy are efficacious completion for histopathological diagnosis. We recommend an age/risk appropriate screening to detect risk factors and early disease in the asymptomatic patients.

[Agnogenic myeloid metaplasia in pregnancy. Case report]. / Metaplazia mieloida agnogenica si sarcina. Prezentare de caz.

UNLABELLED: Idiopathic myelofibrosis is a rare myeloproliferative disorder characterized by excessive accumulation of connective tissue in the bone marrow in association with anemia, splenomegaly and extramedullary hematopoiesis. A rare case of pregnancy in a patient with agnogenic myeloid metaplasia who carried a term pregnancy is described. In spite of the increased perinatal risks, a favorable outcome was possible with close antepartum surveillance. CONCLUSION: Idiopathic myelofibrosis was once thought to be a contraindication to pregnancy. With careful management, successful pregnancies can be achieved.

[Post-cesarean acute aortic dissection in a Marfan syndrome patient]. / Disectie acuta de aorta postcezariana la o lehuza cu sindrom marfan. Prezentare de caz.

Marfan syndrome is an uncommon condition in pregnancy. We present the case of 37 years old gravida 1, para 1 with Marfan syndrome. She delivered at term by cesarean section, a healthy male infant weighing 3500 grams with Apgar's of 9. During the postoperative period she developed aortic dissection and was referred to the Cardiovascular Surgery Department. We described such a case and the difficult decisions that we faced.

[Oral modifications during menopause]. / Modificari orale la menopauza.

The menopause, a physiological process specific to elderly women (>50 years) is defined by various involutive phenomena occurred at general level and particularly in the stomatognatic system elements. The authors followed the influence of the oral contraceptives in changes of oral tissues during menopause. The study was carried on 148 elderly women during menopause split in two groups: group I (study group) who have used oral contraceptives in earlier years, group II (control group) without contraceptive therapy. The evaluation of the results was made using clinical exams and complementary investigations (X-ray, cytological, histopathological, mycological, salivary rate exams) and index quantification. The results showed the importance of the apparition of changes in to the oral tissues during menopause increased in comparison to the control group. Corresponding prevention strategies are the basis of oral health management in women at menopause.