[Pathophysiologic characteristics of the reactive toxic stage of acute suppurative peritonitis and ways to enhance the effectiveness of intensive therapy]. / Patofiziologicheskie osobennosti reaktivno-toksicheskoi stadii ostrogo gnoinogo peritonita i puti povysheniia éffektivnosti intensivnoi terapii.

The oxygen regimen, circulation, and metabolism were studied in 95 patients in the reactive-toxic stage of diffuse purulent peritonitis. The results of cluster analysis made it possible to determine the clinical and pathophysiological features of the phases of the disease. The phase of compensation was characterized by disorders of mass exchange of plasma water which led to increased index of transcapillary exchange and increased excess of lactate. These parameters of tissue metabolism were grouped into one cluster together with the oxygen regimen value and mean arterial pressure. The other cluster was formed of the values of oxygen consumption and the values of oxygen systemic and vascular tissue transport and the hemodynamic parameters. In the phase of decompensation the homeostasis parameters were grouped into another 2 clusters. The first contained the indices of transcapillary exchange of oxygen and water, the other--those of the intensity of blood oxygen transport function and metabolism. Surgical treatment and inclusion of the sympatholytic agent ornid and the beta-adrenergic agonist alupent in the complex of intensive therapy from the stages of preoperative and anesthesiological management brought homeostasis to a level characteristic of the phase of compensation, as a result of which fatal outcomes were absolutely excluded.

[Early signs of decompression of the body in acute suppurative peritonitis and ways of increasing the effectiveness of intensive therapy]. / Rannie priznaki dekompensatsii sostoianiia organizma pri ostrom gnoinom peritonite i puti povysheniia éffektivnosti intensivnoi terapii.

In studying the oxygen regimen, circulation and metabolism in 95 patients with acute purulent peritonitis at the toxic stage, it was established that the disorders in transcapillary exchange and oxygen regimen were the early functional criteria for decompensation of the general state of an organism. Differential, in accordance with a phase of the course of the disease, inclusion into the complex of intensive therapy, beginning from the preoperative preparation and anesthesiologic aid, of ornid and ornid with alupent permitted to improve considerably the results of surgical treatment of the patients.

[Anesthesia and intensive therapy in acute suppurative peritonitis]. / Obezbolivanie i intensivnaia terapiia pri ostrom gnoinom peritonite.

The investigation of indices of hemodynamics and oxygen regimen in 58 patients with acute purulent peritonitis has shown the programmed intravenous narcosis in combination with Darenthin to promote increasing the cardiac and stroke index. Darenthin included in the complex intensive therapy of peritonitis was found to increase the portal blood flow and to cause early reestablishment of the intestine peristalsis.