Positive schizotypy and Motor Impulsivity correlate with response aberrations in ventral attention network during inhibitory control.

Inhibitory control (IC) aberrations are present in various psychopathologies, including schizophrenia spectrum and personality disorders, especially in association with antisocial or violent behaviour. We investigated behavioural and neural associations between IC and psychopathology-related traits of schizotypy [Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE)], psychopathy [Triarchic Psychopathy Measure (TriPM)], and impulsivity [Barratt Impulsiveness Scale (BIS-11)], using a novel Go/No-Go Task (GNG) featuring human avatars in 78 healthy adults (25 males, 53 females; mean age = 25.96 years, SD = 9.85) and whole-brain functional magnetic resonance imaging (fMRI) in a separate sample of 22 right-handed healthy individuals (7 males, 15 females; mean age = 24.13 years, SD = 5.40). Behaviourally, O-LIFE Impulsive Nonconformity (impulsive, anti-social, and eccentric behaviour) significantly predicted 16 % of variance in false alarms (FAs). O-LIFE Unusual Experiences (positive schizotypy) and BIS-11 Motor Impulsivity predicted 15 % of d prime (d') (sensitivity index) for the fastest (400 ms) GNG trials. When examined using fMRI, higher BIS-11 Motor Impulsivity uniquely, and also together with Unusual Experiences, was associated with lower activity in the left lingual gyrus during successful inhibition (correct No-Go over baseline). Additionally, higher Impulsive Nonconformity was associated with lower activity in the caudate nucleus and anterior cingulate during No-Go compared to Go stimuli reactions. Positive schizotypy, motor, and antisocial-schizotypal impulsivity correlate with some common but mostly distinct neural activation patterns during response inhibition in areas within or associated with the ventral attention network.

Clinical Psychology and Voice Disorders: A Meta-Analytic Review of Studies Assessing Psychological Characteristics Across Individuals With and Without Voice Disorders.

OBJECTIVES: Clinical voice disorders are heterogenous conditions capturing problems with voice production and control. Psychological conceptualizations of voice disorders posit that mood, anxiety, and personality characteristics contribute to the development and maintenance of voice symptoms. This review brings together research comparing these psychological characteristics across groups with and without voice disorders, with the aim of profiling group differences. METHODS: A systematic search of PubMed, CINAHL, Ovid (PsycInfo, MEDLINE, Embase), and Web of Science databases was conducted, with studies required to assess psychological characteristics between samples with and without voice disorders. Relative study quality and risk of bias were formally evaluated, synthesizing results via meta-analysis (estimating standardized mean difference; SMD) and narrative synthesis. RESULTS: Thirty-nine studies (N = 4740) were reviewed. Marked psychological differences were observed between case-control groups, including significantly higher self-reported features of depression (SMD = 0.50), state anxiety (SMD = 0.58), trait anxiety (SMD = 0.52), health anxiety (SMD = 0.57), and neuroticism (SMD = 0.47) in voice disorder groups. However, less consistent patterns of difference were observed between voice disorder types, including minimal quantitative differences between functional and organic diagnoses. CONCLUSIONS: Findings underline and formulate the psychological features associated with experiencing a voice disorder, indicating individuals with voice disorders present with considerable psychological needs that may benefit from clinical psychology input.

Working Together to Find a Voice: Recommendations for Voice Healthcare Based on Expert-By-Experience and Practitioner Consensus.

OBJECTIVES: Voice care services aim to provide effective and meaningful voice care. Current practice guidance recommends a multidisciplinary voice care approach, supported by the evidence-base and practitioner experience. However, unlike other areas of physical and mental health, current voice care guidance does not explicitly include the voices of experts-by-experience, meaning those who have lived experience of voice difficulties. The perspectives of those working within nonclinical voice professions, such as vocal coaches, are also often omitted. There is therefore a need for updated practice guidance which prioritizes expert-by-experience and nonclinical perspectives. METHODS: Vocal Health Education hosted a consensus meeting in London, UK. The meeting was coproduced with experts-by-experience, and attendees included those with lived experience of voice difficulties and practitioners across a range of disciplines within voice care. The content of the meeting was synthesized into themes and associated recommendations were drafted and agreed to by all attendees. RESULTS: The consensus statement offers practical advice to those working in voice care. Recommendations are offered for multidisciplinary and biopsychosocial voice care, with a focus on person-centered practice and the valuing of lived experience. Through discussion, consensus was reached regarding recommendations for voice care assessment and treatment, practitioner approach, psychosocial considerations, and service design. The need for greater expert-by-experience involvement, coproduction, and co-construction was emphasized throughout. CONCLUSIONS: This report emphasizes the voices of those with lived experience. It highlights ways of updating or improving current care, with the aim of informing clinical practice as well as research and service development. The consensus statement is the first in voice care to include experts-by-experience at the center of its recommendations, underlining the need for more coproduced and co-constructed research and practice within voice healthcare.

Scenario-specific aberrations of social reward processing in dimensional schizotypy and psychopathy.

The feelings of reward associated with social interaction help to motivate social behaviour and influence preferences for different types of social contact. In two studies conducted in a general population sample, we investigated self-reported and experimentally-assessed social reward processing in personality spectra with prominent interpersonal features, namely schizotypy and psychopathy. Study 1 (n = 154) measured social reward processing using the Social Reward Questionnaire, and a modified version of a Monetary and Social Incentive Delay Task. Study 2 (n = 42; a subsample of Study 1) investigated social reward processing using a Social Reward Subtype Incentive Delay Task. Our results show that schizotypy (specifically Cognitive-Perceptual dimension) and psychopathy (specifically Lifestyle dimension) are associated with diverging responses to social scenarios involving large gatherings or meeting new people (Sociability), with reduced processing in schizotypy and heightened processing in psychopathy. No difference, however, occurred for other social scenarios-with similar patterns of increased antisocial (Negative Social Potency) and reduced prosocial (Admiration, Sociability) reward processing across schizotypy and psychopathy dimensions. Our findings contribute new knowledge on social reward processing within these personality spectra and, with the important exception of Sociability, highlight potentially converging patterns of social reward processing in association with schizotypy and psychopathy.

Distinct neural signatures of schizotypy and psychopathy during visual word-nonword recognition.

Previous behavioural data indicate lower word-nonword recognition accuracy in association with a high level of positive schizotypy, psychopathy, or motor impulsivity traits, each with some unique contribution, in the general population. This study aimed to examine the neural underpinnings of these associations using functional magnetic resonance imaging (fMRI) in a volunteer sample. Twenty-two healthy English-speaking adults completed self-report measures of schizotypy (Oxford-Liverpool Inventory of Feelings and Experiences [O-LIFE]), psychopathy (Triarchic Psychopathy Measure [TriPM]), and impulsivity (Barratt Impulsiveness Scale [BIS-11]) and underwent whole-brain fMRI while performing a lexical decision task (LDT) featuring high and low-frequency words, real nonwords, and pseudohomophones. Higher positive schizotypy (Unusual Experiences) was associated with lower cerebellum activity during identification of low-frequency words (over real nonwords). Higher Boldness (fearless dominance) and Meanness (callous aggression) facets of psychopathy were associated with lower striatal and posterior cingulate activity when identifying nonwords over words. Higher Motor Impulsivity was associated with lower activity in the fusiform (bilaterally), inferior frontal (right-sided), and temporal gyri (bilaterally) across all stimuli-types over resting baseline. Positive schizotypy, psychopathy, and impulsivity traits influence word-nonword recognition through distinct neurocognitive mechanisms. Positive schizotypy and psychopathy appear to influence LDT performance through brain areas that play only a supportive (cerebellum) or indirect role in reading-related skills. The negative association between Motor Impulsivity and activations typically found for phonological processing and automatic word identification indicates a reduced bilateral integration of the meaning and sound of mental word representations, and inability to select the appropriate outputs, in impulsive individuals.

Clarifying the roles of schizotypy and psychopathic traits in lexical decision performance.

INTRODUCTION: Some studies suggest that lexical recognition is impaired in people with schizophrenia, psychopathy and/or antisocial personality disorders, but not affective disorders. We examined the extent to which various traits dimensionally linked to one or more of these disorders are associated with lexical recognition performance in the general population. METHODS: Seventy-eight healthy English-speaking participants completed self-report measures of schizotypy, psychopathy, impulsivity, depression, anxiety and stress. All participants were assessed on a one-choice variant of a lexical decision task (LDT). RESULTS: Meanness and Boldness traits of psychopathy (Triarchic Psychopathy Measure), and positive schizotypy (Unusual Experiences, Oxford-Liverpool Inventory of Feelings and Experiences) were associated with poor word-nonword accuracy, and predicted a significant amount of unique variance (Meanness, 12%; Boldness, 4.8%; Positive Schizotypy, 4.4%; total 21%) in performance. Higher motor impulsivity predicted 30% of the variance in low-frequency words recognition accuracy, but only in non-native English speakers. Affective traits were not associated with LDT performance. CONCLUSION: Psychopathic traits show stronger negative associations with lexical recognition performance than schizotypal traits, and impulsivity may differently influence lexical decision performance in native and non-native speakers. Further studies are needed to replicate these findings, especially the influence of language familiarity in the impulsivity-performance relationship, and to clarify the influence of corresponding symptom dimensions in lexical recognition abilities, taking language familiarity, migration status, and comorbidity into account, in people with schizophrenia, psychopathy, and/or antisocial personality disorders.

The Impact of the COVID-19 Pandemic on Forensic Mental Health Services and Clinical Outcomes: A Longitudinal Study.

BACKGROUND: The COVID-19 pandemic has had a substantial impact on forensic mental health service provision and implementation. This study aimed to provide an analysis of the impact of COVID-19 related restrictions on routine outcomes within a large forensic mental health service in London, UK. METHOD: We conducted a longitudinal cohort study using data collected routinely prior to the COVID-19 pandemic (April 2018-March 2020) and then stages thereafter (March 2020-March 2021; analyzed as March-May 2020, June-September 2020, October-December 2020, January-March 2021). We used causal impact models (Bayesian structural time-series) to examine the effect of COVID-19 related changes on routine outcomes related to service provision and implementation. RESULTS: There was an overall increase in long-term segregation (LTS) hours during the pandemic; 140%, (95% Cl 107, 171%) during Lockdown 1; 113%, (159% Cl 127, 192%) during post-Lockdown 1; 45% (95% Cl 23, 68%) during Lockdown 2 and, finally, 90% (95% Cl 63, 113%) during Lockdown 3. The most negative outcomes were evident during Lockdown 3. Incidents of violence were significantly more frequent during Lockdown 3 than would have been predicted based on pre-pandemic data, including physical assaults to service users (206%, 95% CI 57%, 346%), non-physical assaults to service users (206%, 95% CI 53%, 339%), and self-harm (71%, 95% CI 0.4%, 135%). Use of enforced medication also increased during Lockdown 3 (317%, 95% CI 175%, 456%). CONCLUSION: The pandemic and its related restrictions negatively affected some service outcomes. This resulted in increased incidents of violence and increased use of restrictive interventions, beyond what would have been expected had the pandemic not occurred.

Atypical social reward anticipation as a transdiagnostic characteristic of psychopathology: A meta-analytic review and critical evaluation of current evidence.

Several psychopathologies (e.g. schizophrenia spectrum conditions, autism spectrum disorders) are characterised by atypical interpersonal and social behaviour, and there is increasing evidence to suggest this atypical social behaviour is related to adjusted behavioural and neural anticipation of social rewards. This review brings together social reward anticipation research in psychopathology (k = 42) and examines the extent to which atypical social reward anticipation is a transdiagnostic characteristic. Meta-analyses of anticipatory reaction times revealed that, in comparison to healthy controls, attention-deficit/hyperactivity disorder, autism spectrum disorder, and schizophrenia spectrum conditions are associated with significantly reduced behavioural anticipation of social rewards. The pooled meta-analysis of anticipatory reaction times found that the full clinical sample demonstrated significant social reward hypoanticipation in comparison to the healthy control group with a medium effect size. A narrative synthesis of meta-analytically ineligible behavioural data, self-report data, and neuroimaging studies complemented the results of the meta-analysis, but also indicated that bipolar disorder, eating disorders, and sexual addiction disorders may be associated with social reward hyperanticipation. The evaluation of existing evidence suggests that future research should better account for factors that affect reward anticipation (e.g. gender, psychotropic medication) and highlights the importance of using stimuli other than happy faces as social rewards.

Reading skills deficits in people with mental illness: A systematic review and meta-analysis.

BACKGROUND: Good reading skills are important for appropriate functioning in everyday life, scholastic performance, and acquiring a higher socioeconomic status. We conducted the first systematic review and meta-analysis to quantify possible deficits in specific reading skills in people with a variety of mental illnesses, including personality disorders (PDs). METHODS: We performed a systematic search of multiple databases from inception until February 2020 and conducted random-effects meta-analyses. RESULTS: The search yielded 34 studies with standardized assessments of reading skills in people with one or more mental illnesses. Of these, 19 studies provided data for the meta-analysis. Most studies (k = 27; meta-analysis, k = 17) were in people with schizophrenia and revealed large deficits in phonological processing (Hedge's g = -0.88, p < 0.00001), comprehension (Hedge's g = -0.96, p < 0.00001) and reading rate (Hedge's g = -1.22, p = 0.002), relative to healthy controls; the single-word reading was less affected (Hedge's g = -0.70, p < 0.00001). A few studies in affective disorders and nonforensic PDs suggested weaker deficits (for all, Hedge's g < -0.60). In forensic populations with PDs, there was evidence of marked phonological processing (Hedge's g = -0.85, p < 0.0001) and comprehension deficits (Hedge's g = -0.95, p = 0.0003). CONCLUSIONS: People with schizophrenia, and possibly forensic PD populations, demonstrate a range of reading skills deficits. Future studies are needed to establish how these deficits directly compare to those seen in developmental or acquired dyslexia and to explore the potential of dyslexia interventions to improve reading skills in these populations.

Predictive power of the DASA-IV: Variations in rating method and timescales.

This project evaluated the predictive validity of the Dynamic Appraisal of Situational Aggression - Inpatient Version (DASA-IV) in a high-secure psychiatric hospital in the UK over 24 hours and over a single nursing shift. DASA-IV scores from three sequential nursing shifts over a 24-hour period were compared with the mean (average of three scores across the 24-hour period) and peak (highest of the three scores across the 24-hour period) scores across these shifts. In addition, scores from a single nursing shift were used to predict aggressive incidents over each of the following three shifts. The DASA-IV was completed by nursing staff during handover meetings, rating 43 male psychiatric inpatients over a period of 6 months. Data were compared to incident reports recorded over the same period. Receiver operating characteristic (ROC) curves and generalized estimating equations assessed the predictive ability of various DASA-IV scores over 24-hour and single-shift timescales. Scores from the DASA-IV based on a single shift had moderate predictive ability for aggressive incidents occurring the next calendar day, whereas scores based on all three shifts had excellent predictive ability. DASA-IV scores from a single shift showed moderate predictive ability for each of the following three shifts. The DASA-IV has excellent predictive ability for aggressive incidents within a secure setting when data are summarized over a 24-hour period, as opposed to when a single rating is taken. In addition, it has moderate value for predicting incidents over even shorter timescales.