Subject(s)
Breast Neoplasms , Quality of Life , Socioeconomic Factors , Surveys and Questionnaires , Analysis of Variance , Breast Neoplasms/complications , Breast Neoplasms/psychology , Breast Neoplasms/surgery , Female , Humans , Kazakhstan , Middle Aged , Statistics, Nonparametric , Surveys and Questionnaires/standards , TranslationsABSTRACT
The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989. These results then were compared to cancer patients and healthy individuals with no radiation risk. The study revealed the presence of higher levels of endothelial dysfunction and following trigger of the hemostatic system in patients with malignant tumors of the gastrointestinal tract. In particular, the defined high degree of endothelial dysfunction include endothelium- dependent vasodilation, content desquamated endothelial cells in peripheral blood and von Willebrand factor. These indicators have a clear correlation with the degree of disorder of studied parameters of the hemostasis, which can cause the development of thrombotic complications.
Subject(s)
Endothelium, Vascular/pathology , Gastrointestinal Neoplasms/pathology , Radiation, Ionizing , Aged , Case-Control Studies , Endothelium, Vascular/radiation effects , Female , Follow-Up Studies , Gastrointestinal Neoplasms/blood supply , Gastrointestinal Neoplasms/metabolism , Gastrointestinal Neoplasms/radiotherapy , Hemostasis/radiation effects , Humans , Kazakhstan , Male , Middle Aged , Prognosis , von Willebrand Factor/metabolismABSTRACT
Colorectal cancer incidence and mortality in Kazakhstan are relatively high but exact statistics have hitherto been lacking and trends over time are unclear. The present study was therefore undertaken to retrospectively assess data for East Kazakhstan, accessed from the central registration office, for the period 2004-2013. Approximate age standardized data for incidence and mortality were generated and compared across age groups, gender and year. It was determined that during the studied period 3,417 new cases of colorectal cancer were registered and 2,259 died of this pathology. Average cancer cancer incidence and mortality over the ten years were 24.1/105 and 15.9/105 respectively, and the overall ratio of mortality/incidence (M/I) was 0.69:1 (range 0.58-0.73). Both incidence and mortality tended to remain constant in both males and females. The male to female ratios also did not significantly vary over time but a trend for improvement of the mortality to incidence ratio was observed, especially for rectum. Whether this might be related to screening remains unclear. These preliminary data indicate that whereas colorectal cancer continues to be important, change in environmental factors are not having a great impact on incidence in East Kazakhstan.
