ABSTRACT
Two new phytotoxic polyketides, tagetolone (1) and tagetenolone (2), in addition to tyrosol and p-hydroxybenzoic acid, have been isolated from the organic crude extract of culture filtrates from the fungal pathogen Alternaria tagetica. Complete characterization of all structures was carried out following a careful analysis of their spectroscopic data (IR, MS, (1)H and (13)C NMR, and 2D NMR experiments).
Subject(s)
Alternaria/chemistry , Mycotoxins/chemistry , Parabens/chemistry , Phenylethyl Alcohol/analogs & derivatives , Alternaria/growth & development , Alternaria/pathogenicity , Magnetic Resonance Spectroscopy , Mass Spectrometry , Molecular Structure , Mycotoxins/isolation & purification , Parabens/isolation & purification , Parabens/pharmacology , Phenylethyl Alcohol/isolation & purification , Plants/microbiology , Xylenes/chemistryABSTRACT
Two novel polyketides, bis-7-O-8' '.8-O-7' '- and bis-7-O-7' '. 8-O-8' '-zinniol (2 and 3, respectively) were isolated from the organic crude extract of culture filtrates from Alternaria tagetica. Both structures were determined on the basis of their spectroscopic data (IR, MS, (1)H NMR, (13)C NMR, and 2D NMR experiments) and confirmed by chemical synthesis. Zinniol (1) was isolated as a major component, and its (13)C NMR data was correctly assigned after careful analysis of data from its 2D NMR experiments (HMQC and HMBC).
