[An experimental and clinical study of Ossocol, a compound of hydroxylapatite and collagen]. / Izuchenie v éksperimente i klinike kompozitsii gidroksilapatita c kollagenom--"Ossokola".

Experiments on white rats revealed that introduction of Ossocol, a sponge with a composition of hydroxyl apatite with collagen, into a removed tooth well prevented mandibular atrophy and was conducive to a more smooth defect filling with better compact bone tissue. Ossocol use in 214 patients with bone tissue defects developing after tooth removal, of odontogenic cysts, sequestra, and after radical surgery for periodontal diseases demonstrated a positive effect of this agent on the course of the postoperative period: the defect was more rapidly replaced by bone tissue. No unfavorable local or general reactions to Ossocol implantation were observed.

[The effect of hydroxylapatite on the experimental healing of the tooth socket]. / Vliianie gidroksilapatita na zazhivlenie lunki zuba v éksperimente.

Synthetic hydroxylapatite, a drug made in this country, enhanced reparative osteogenesis if introduced in the dental well of a white rat. The regenerate represented solid bone structure in 4 months after tooth removal.

[The modelling of mandibular osteomyelitis]. / Modelirovanie osteomielita nizhnei cheliusti.

The method suggested by the authors permits a reliable reproduction of mandibular osteomyelitis in white rats. The primary localization and pattern of the infectious process in this model well correspond to odontogenic osteomyelitis, this permitting a preclinical study of new drugs and physiotherapeutic methods intended for patients with odontogenic diseases.