[Age-related changes in the reaction of the adrenal cortex to surgical stress in cancer patients]. / Vozrastnye izmeneniia reaktsii kory nadpochechnikov na operatsionnyi stress u onkologicheskikh bol'nykh.

11-Oxycorticosteroids levels were determined in 371 patients with breast, stomach and rectal cancer in the process of surgical treatment. More pronounced reaction of the adrenal cortex to surgical stress and/or time-delayed restoration of the hormone level within the next few days were found in older patients. Resistance to inhibition by dexamethasone in stomach cancer patients was accompanied by elevated cortisol levels during operation. It is concluded that age-related decrease in hypothalamo-pituitary complex sensitivity to inhibition by corticosteroids may be a cause of hypercortisolemia in the course of surgery.

[Blood concentration of halothane and its effect on catecholamine levels and hemodynamics in cancer patients during surgery]. / Kontsentratsiia ftorotana v krovi i ee vliianie na soderzhanie katekholaminov i gemodinamiku u onkologicheskikh bol'nykh vo vremia operatsii.

The investigation of 22 patients has established the concentration of fluothane in the blood to influence the catecholamine content and the cardio-vascular system. Its increased concentration in the blood results in certain decrease of the level of general catecholamines in the blood, decreased value of systolic arterial pressure and increased frequency of cardiac contractions.

[Sympathetic-adrenal system in various types of anesthesia in surgical treatment of gastric and rectal cancer]. / Sostoianie simpatiko-adrenalovoi sistemy pri nekotorykh vidakh narkoza u bol'nykh rakom zheludka i priamoi kishki.

Under study was the functional activity of the sympatho-adrenal system in identical surgical interventions in 44 gastric cancer patients and 77 rectal cancer patients, operated under nitrogen monoxide-ether, nitrogen monoxide-fluothane anesthesia and under neuroleptanalgesia supplemented with nitrogen monoxide. The sympatho-adrenal activity was assessed, taking into account the content of total catecholamines (adrenaline and noradrenaline) in blood and urine prior to surgery, intraoperatively before anesthesia, during the most traumatizing moment of the operation and at 1, 3, 6 day after it. It was found that in identical operative procedures stimulation of the sympatho-adrenal system is mostly manifest in patients operated upon under either anesthesia and neuroleptanalgesia. Use of fluothane narcosis in gastric cancer patients produced no marked activation of the sympatho-adrenal system, while in rectal cancer patients it was not so significant as in either narcosis and neuroleptanalgesia.

[Aspects of the combined treatment of rectal cancer]. / Nekotorye aspekty kombinirovannogo lecheniia raka priamoi kishki.

A comparative estimation of the results of the treatment for rectal cancer in 2 groups of patients has shown the number of postoperative complications following the combined method to be 68.5%, while in surgical method-51.4%. Greater incidence of complications was dependent on the technic of irradiation employed, and to a certain extent, could be due to a more pronounced reduction of the sympatho-adrenal system activity and immunobiological reactivity of the organism in this group of patients. The postoperative mortality was approximately the same and yielded 9.9% in the combined and 11.7% in surgical treatment.

[Anesthesia and distant results of surgical treatment in patients with stomach cancer]. / Vid narkoza i otdalennye rezul'taty khirurgicheskogo lecheniia bol'nykh rakom zheludka.

Based on the study of the late results of surgical treatment in 373 patients with gastric cancer, subjected to radical subtotal gastrectomy, it was found that a group of patients operated under fluothane anesthesia shows the highest survival rate. As evidenced by the authors' findings the use of ether narcosis results in 16--27% reduction of yearly survival during the first five years. The most poor results were noted in a group of patients operated under neuroleptanalgesia.

[Analysis of complications of synchronous combined excision of rectal cancer]. / Analiz oslozhenii dvukhbrigadnykh operatsii po povodu raka priamoi kishki

Based on the data of 185 patients the immediate results of surgical treatment for rectal cancer are discussed. The total number of intraoperative complications was 6.5%. Postoperatively, complications were noted in 65.2%. The authors consider the dependence of complications on such factors as sex, age, patients' obesity, stage of the process and the kind of surgical intervention.