ABSTRACT
The article is devoted to an actual problem of surgical treatment of patients with posttraumatic deformities of the orbital floor. On the material of 21 observations it was shown that for the successful treatment of deformities of the orbit bottom autogenous costal cartilage graft should be used as a plastic material. Removal of enophthalmos in longstanding fractures can be reached only by reducing the volume of the orbit which can be achieved by retrobulbar placement of the graft. An analysis of the results demonstrated high efficiency of this method in the treatment of such patients.
Subject(s)
Enophthalmos/surgery , Facial Transplantation/methods , Orbit/surgery , Orbital Fractures/surgery , Plastic Surgery Procedures/methods , Adult , Cartilage , Enophthalmos/etiology , Female , Humans , Male , Orbit/injuries , Orbit/pathology , Orbital Fractures/complications , Orbital Fractures/pathology , Time , Transplantation, Autologous/methods , Treatment OutcomeABSTRACT
We present a novel scoring function for docking of small molecules to protein binding sites. The scoring function is based on a combination of two main approaches used in the field, the empirical and knowledge-based approaches. To calibrate the scoring function we used an iterative procedure in which a ligand's position and its score were determined self-consistently at each iteration. The scoring function demonstrated superiority in prediction of ligand positions in docking tests against the commonly used Dock, FlexX and Gold docking programs. It also demonstrated good accuracy of binding affinity prediction for the docked ligands.