Effect of glycine on microcirculation in pial vessels of rat brain.

Single application of glycine in a final dose of 40 mg/kg to the surface of the parietal area of rat brain produced a potent vasodilatory effect. The diameter of arterioles increased to 250% from the baseline level 1-3 min after treatment. These changes persisted for 5-10 min. In the follow-up period the diameter of vessels progressively decreased to the baseline level. Repeated application of glycine in the same dose also induced dilation of arterioles. Application of physiological saline under similar conditions did not produce these changes.

Effect of orthophen on microlymphocirculation during fever reaction.

Orthophen improved lymph flow during fever reaction via stimulation of contractile activity of the wall and valves in mesenteric lymphatic vessels of rat small intestine. These changes constitute the pathogenetic mechanism for the effect of orthophen during fever.

[The intravital study of microcirculation in subcutaneous fat in rats with implanted camera]. / Metod prizhiznennogo izucheniia mikrotsirkuliatsii v podkozhnoi zhirovoi kletchatke krysy s pomoshch'iu vzhivlennoi kamery.

The authors present a novel method for investigation of microhemo- and microlymphocirculation in subcutaneous fat of rat implanted a special camera. Lighting of the subcutaneous fat with application of fiberoptics provides a sharp image of microvascular wall and blood cells.

Possibility of linear dependence between vascular wall tension and blood flow in precortical arterioles.

Intravital microscopy was used to determine the diameter and length of pial cortical arterioles in rat brain. Mathematical model yielded a formula showing that regulation of arteriolar wall tension results in autoregulation of the blood flow.

[Changes in the gingival microcirculatory bed in health and experimental periodontitis]. / Izmeneniia mikrotsirkuliatornogo rusla desny v norme i pri éksperimental'nom parodontite.

Normally the rat gingival microcirculatory bed is represented by superficial capillaries, postcapillaries, arterioles, and venules of different diameters. The major changes characterizing microcirculation disorders in experimental periodontitis are edema, arteriolar constriction and dilatation, stasis, and thrombosis, which undergo variously directed shifts in different periods of pathological process.

[The microcirculation and the succinate and NADH dehydrogenase activities of the brain in neurotic disorders of the higher nervous activity in white rats]. / Mikrotsirkuliatsiia i aktivnost' degidrogenaz SDG i NADH-DG mozga pri nevroticheskikh narusheniiakh vysshei nervnoi deiatel'nosti u belykh krys.

A correlation was made between microcirculation and energy metabolism in the brain of 50 neurotized rats. Neurotic disorders were defined by characteristics of conditioning, arterial pressure, breathing rate and heart rate. In vivo biomicroscopy revealed modification of the state of blood vessels at rest and inverted reaction of brain pial vessels of neurotized rats to bilateral occlusion of common carotid arteries. Ratio of activities of respiratory cycle enzymes (succinate and NADH-dehydrogenases) was indicative of hypoxic state of the animals under study.

[The effect of the alpha-adrenoblocker tropafen on the microcirculation and the hematocrit index in the capillaries of rats with ischemia]. / Vliianie al'fa-adrenoblokatora tropafena na mikrotsirkuliatsiiu i pokazatel' gematokrita v kapilliarakh krys pri ishemii.

The ischemia-induced decrease of the hematocrit index was the greatest in precapillaries and smallest capillaries. Significant oscillations of the index occurred in reperfusion. Tropafen decreased the index. Applied prior to ischemia, tropafen did not affect microcirculation and redistribution of erythrocytes during ischemia and reperfusion.

[Microcirculatory disorders in cerebral ischemia in rats and their correction by using leu-enkephalin]. / Narusheniia mikrotsirkuliatsii pri ishemii mozga u krys i korrketsiia ikh s pomoshch'iu lei-énkefalina.

Leu-enkephalin (LE) induced mainly a constriction of pial arterioles, diameter of the venules did not change. The effect of the LE involved preservation of the cerebral blood flow and that in microvessels, constriction of some arterioles and reduced dilatation against the background of decreased arterial pressure, bradycardia, increased lymphatic flow and survival of the animals during first hours of occlusion of common carotid arteries.

[The nonuniform sensitivity of the cerebral vessels to serotonin]. / Neodinakovaia chuvstvitel'nost' sosudov mozga k serotoninu.

With serotonin, cerebral blood flow decreased to a great degree during multiple injections. Serotonin was found to produce different effects on brain arterial vessels. It enhanced the resistance of carotid arteries to a greater degree than that in the cerebrobasilar system. Serotonin constricted pial arterioles with an initial diameter of more than 40 nm, whereas the microvessels of less diameter got substantially dilated. The agent had a depriming effect on somatosympathetic and vasomotor reflexes via its interaction with central noradrenergic structures.

[Effect of lithium oxybutyrate on microcirculation in the mucous membrane of the hamster cheek pouch in the postischemic period]. / Vliianie oksibutirata litiia na mikrotsirkuliatsiiu v slizistoi obolochke zashchechnogo meshka khomiachka v postishemicheskom periode.

It was demonstrated in experiments on hamsters that lithium oxybutyrate (preliminary or therapeutic injection in a dose of 400 mg/kg) leads to relative normalization of microcirculation and secretory activity of the mast cells. Lithium oxybutyrate can be used for the prevention and treatment of postischemic disorders.

[Effects of femto- and picomolar concentrations of thyroliberin and tuftsin on the contractile activity of lymphatic vessels of the rat mesentery]. / Deistvie femto- i pikomoliarnykh kontsentratsii tiroliberina i taftsina na sokratitel'nuiu aktivnost' limfaticheskikh sosudov bryzheiki krysy.

Thyrotropin-releasing-hormone (TRH) in concentration from I g/ml to 1.10(-10) micrograms/ml and tuftsin (T) (10 micrograms/ml to 1.10(-6) micrograms/ml) biomicroscopy were used in rats to show the ability to activate the contraction of lymphatic microvascular walls. TRH in used concentrations stimulated spontaneously contractility of lymphatic vessel's walls or evoked its contractility when it was absent. T stopped the contraction of lymphatic microvascular walls and caused the reaction of vasodilatation.