ABSTRACT
Mutagenic activity of vegetative preparation KAC-81 containing extracts of common wormwood and pine buds using crepis root seedlings, unicellular green alga of Chlorella indicator strains of Salmonellas TA 100, TA 1534, TA 1537, TA 50 and TA 98 as well as white mice and white rats has been studied. It is shown that the preparation caused a weak mutagenic effect on Crepis seedlings and Chlorella and no mutagenic effects on the indicator strains of salmonellas, in sex and somatic cells of mammals under single peroral action in maximally endured doses.
Subject(s)
Mutagens/toxicity , Animals , Chlorella/drug effects , Chlorella/genetics , Mice , Mutagenicity Tests/methods , Plants/drug effects , Plants/genetics , Rats , Salmonella typhimurium/drug effects , Salmonella typhimurium/genetics , Species SpecificityABSTRACT
Toxicity and genetic activity of disinfectant consisting of 1.5% paraform and 0.5% NaOH were studied. It was found that the preparation caused a weak mutagenic effect on Crepis capillaris and Chlorella roots, but had no effect in the Ames test and gonadal cells of mammals. The studies of mutagenic effect of the preparation on somatic cells of white mice show limits of the cytogenetic effect at the level of 3.5 g/kg (1/10 LD50).
