ABSTRACT
Experimental evaluation of Bengal rose labeled with short-lived 123I was performed. The best diagnostic feature in 123I-Bengal rose were shown during a scintigraphic study of the rabbit liver and biliferous tract conducted in simultaneous experiments with the use of the agent labeled with 131I and 99mTc-HIDA. These were a high quality of the image of the organs, a low radiation exposure and the absence of extrahepatic uptake of the agent, particularly under conditions of the ligament of the common bile duct. The absence of a noticeable toxic effect of 123I-Bengal rose was established in experiments on rats and mice.
Subject(s)
Iodine Radioisotopes , Liver/diagnostic imaging , Rose Bengal , Animals , Evaluation Studies as Topic , Male , Mice , Rabbits , Radionuclide Imaging , Rats , Rose Bengal/toxicityABSTRACT
Thermoluminescent dosimetry in the Mix-D material was used to study the dosimetric characteristics of discrete sources in the form of titanium and nylon capsules, sizes 0.8 X 2.5 and 1.7 X 7 mm with an activity of 20-40 MB K. Permissible within the limits of volume subject to radiotherapy, dose field parameters and a higher dose gradient beyond the field limits as compared to 226Ra, 198Au and 192Ir were established. Manufactured 125I discrete sources meet the requirements of interstitial radiation therapy in the protracted tumor irradiation mode.
